{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:23:34Z","timestamp":1787729014267,"version":"build-2784847793"},"reference-count":8,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1988,3]]},"abstract":"<jats:p>Twenty-nine patients with Apert's syndrome were ascertained through hospital records. The mean age was 19.3 years (range eight to 35 years). Further information was obtained on their intelligence, education, and employment records. Fourteen patients (48%) had a normal or borderline IQ (greater than 70), nine patients (31%) were mildly mentally retarded (IQ 50 to 70), four patients (14%) were moderately retarded (IQ 35 to 49), and two patients (7%) were severely retarded (IQ less than 35). Early craniectomy did not appear to improve intellectual outcome. Six of the seven school leavers with normal or borderline intelligence were in full time employment or vocational training.<\/jats:p>","DOI":"10.1136\/jmg.25.3.164","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:11:11Z","timestamp":1226329871000},"page":"164-167","source":"Crossref","is-referenced-by-count":72,"title":["Intellectual development in Apert's syndrome: a long term follow up of 29 patients."],"prefix":"10.1136","volume":"25","author":[{"given":"M A","family":"Patton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Goodship","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Hayward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Lansdown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1988,3,1]]},"reference":[{"key":"ref_1","first-page":"238","article-title":"Two specimens of congenital cranial deformity in infants associated with fusion of the fingers and toes","volume":"45","author":"Wheaton, S.W.","year":"1894","unstructured":"Wheaton SW. Two specimens of congenital cranial deformity in infants associated with fusion of the fingers and toes. Trans Pathol Soc London 1894;45:238-9.","journal-title":"Trans Pathol Soc London"},{"issue":"23","key":"ref_2","first-page":"1310","volume":"1906","author":"L'acrocephalosyndactylie, Apert E.","unstructured":"Apert E. L'acrocephalosyndactylie. Bull Soc Med 1906;23: 1310-13.","journal-title":"Bull Soc Med"},{"issue":"24","key":"ref_3","first-page":"151","article-title":"Apert's syndrome (a type of acrocephalosyndactyly): observations on a British series of thirty-nine cases","volume":"1960","author":"Blank, C.E.","unstructured":"Blank CE. Apert's syndrome (a type of acrocephalosyndactyly): observations on a British series of thirty-nine cases. Ann Hum Genet 1960;24:151-64.","journal-title":"Ann Hum Genet"},{"key":"ref_4","first-page":"13","article-title":"Craniosynostosis and syndromes with craniosynostosis: incidence, genetics, penetrance, variability and new syndrome updating","volume":"5","author":"Cohen, M.M.","year":"1979","unstructured":"Cohen MM. Craniosynostosis and syndromes with craniosynostosis: incidence, genetics, penetrance, variability and new syndrome updating. Birth Defects 1979;XV(5B):13-63.","journal-title":"Birth Defects"},{"key":"ref_5","article-title":"The craniosynostoses","author":"David, D.J.; Poswillo, D.; Simpson, D.","year":"1982","unstructured":"David DJ, Poswillo D, Simpson D. The craniosynostoses. Berlin: Springer Verlag, 1982."},{"key":"ref_6","first-page":"1","article-title":"The premature synostosis of the cranial sutures","volume":"51","author":"Bertelsen, T.I.","year":"1958","unstructured":"Bertelsen TI. The premature synostosis of the cranial sutures. Acta Ophthalmol 1958;51:1-176.","journal-title":"Acta Ophthalmol"},{"key":"ref_7","first-page":"782","article-title":"International classification of impairments, disabilities and handicaps","volume":"79","author":"Organization, World Health","year":"1980","unstructured":"World Health Organization. International classification of impairments, disabilities and handicaps. Geneva: WHO, 1980. x Hogan GR, Bauman ML. Hydrocephalus in Apert's syndrome. J Pediatr 1971;79:782-7.","journal-title":"J Pediatr; x Hogan GR, Bauman ML. Hydrocephalus in Apert's syndrome"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1192\/bjp.107.448.459","article-title":"A critique of current views on acrocephaly and related conditions","volume":"107","author":"Crome, L.","year":"1961","unstructured":"Crome L. A critique of current views on acrocephaly and related conditions. J Ment Sci 1961;107:459-74.","journal-title":"J Ment Sci"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.25.3.164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T17:02:39Z","timestamp":1760720559000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.25.3.164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,3]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1988,3,1]]},"published-print":{"date-parts":[[1988,3]]}},"alternative-id":["10.1136\/jmg.25.3.164"],"URL":"https:\/\/doi.org\/10.1136\/jmg.25.3.164","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"value":"0022-2593","type":"print"},{"value":"1468-6244","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,3]]}}}