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Overall, the recurrence rate was 3% for sibs and 5.5% for offspring of index cases. Review of published reports of familial cases of mitochondrial myopathy suggests that the ratio of maternal to paternal transmission is about 9:1. We conclude that these disorders may be caused by mutations of either nuclear or mitochondrial genes.<\/jats:p>","DOI":"10.1136\/jmg.25.8.528","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:11:11Z","timestamp":1226329871000},"page":"528-535","source":"Crossref","is-referenced-by-count":25,"title":["Mitochondrial myopathy: a genetic study of 71 cases."],"prefix":"10.1136","volume":"25","author":[{"given":"A E","family":"Harding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R K","family":"Petty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Morgan-Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1988,8,1]]},"reference":[{"issue":"193-21","key":"ref_1","first-page":"1","article-title":"Oculocraniosomatic neuromuscular disease with 'ragged red'","volume":"26","author":"Olson, W.; Engel, W.K.; Walsh, G.O.; Einaugler, R.","year":"1972","unstructured":"Olson W, Engel WK, Walsh GO, Einaugler R. 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