{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:20:24Z","timestamp":1761153624560,"version":"build-2065373602"},"reference-count":19,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1989,5]]},"abstract":"<jats:p>Cytogenetic re-evaluation of a fibroblast cell line from a female Hunter's syndrome case with a balanced X;autosome translocation, which had previously been reported to have a breakpoint in Xq26 to Xq27, showed the breakpoint to be either between Xq27 and Xq28 or within Xq28. The normal X chromosome was preferentially inactivated, supporting the view that the translocation had disrupted the Hunter gene. The new localisation is now in full agreement with our previous linkage work and other published data. Results of further linkage studies using probes defining the loci DXS86, DXS144, DXS100, DXS102, DXS105, F8C, and DXS134 are also consistent with our original conclusion that the Hunter locus lies within the distal region of the X chromosome long arm.<\/jats:p>","DOI":"10.1136\/jmg.26.5.309","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:11:11Z","timestamp":1226329871000},"page":"309-313","source":"Crossref","is-referenced-by-count":22,"title":["Further evidence localising the gene for Hunter's syndrome to the distal region of the X chromosome long arm."],"prefix":"10.1136","volume":"26","author":[{"given":"S H","family":"Roberts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Upadhyaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Sarfarazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P S","family":"Harper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/BF00280492","article-title":"Localisation of the gene for Hunter syndrome on the long arm of the X chromosome","volume":"74","author":"Upadhyaya, M.; Sarfarazi, M.; Bamforth, J.S.","year":"1986","unstructured":"Upadhyaya M, Sarfarazi M, Bamforth JS, et al. Localisation of the gene for Hunter syndrome on the long arm of the X chromosome. Hum Genet 1986;74:391-8.","journal-title":"Hum Genet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF00284915","article-title":"Ten families with fragile X syndrome: linkage relationships with four DNA probes from distal Xq","volume":"76","author":"Buchanan, J.A.; Buckton, K.E.; Gosden, C.M.","year":"1987","unstructured":"Buchanan JA, Buckton KE, Gosden CM, et al. Ten families with fragile X syndrome: linkage relationships with four DNA probes from distal Xq. Hum Genet 1987;76:165-72.","journal-title":"Hum Genet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1159\/000132481","article-title":"Report of the committee on the genetic constitution of the X and Y chromosomes. HGM9","volume":"46","author":"Davies, K.E.; Mandel, J.L.; Weissenbach, J.; Fellous, M.","year":"1987","unstructured":"Davies KE, Mandel JL, Weissenbach J, Fellous M. 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