{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:07:55Z","timestamp":1761718075775,"version":"build-2065373602"},"reference-count":14,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1990,3]]},"abstract":"<jats:p>Three patients with different marker chromosomes were screened by in situ hybridisation using biotinylated probes to chromosome specific pericentric repeats to determine the chromosomal origin of the marker. Each marker had a different origin, with one from each of chromosomes 1, 9, and 16. This is the first time that autosomal marker chromosomes consisting of a small ring have been shown to be derived from the pericentric heterochromatin of metacentric and submetacentric chromosomes. Evidence suggests that such markers are not associated with any significant risk of phenotypic abnormalities, but additional cases need to be studied.<\/jats:p>","DOI":"10.1136\/jmg.27.3.155","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:11:11Z","timestamp":1226329871000},"page":"155-159","source":"Crossref","is-referenced-by-count":50,"title":["Small marker chromosomes in man: origin from pericentric heterochromatin of chromosomes 1, 9, and 16."],"prefix":"10.1136","volume":"27","author":[{"given":"D F","family":"Callen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M L","family":"Ringenbergs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J C","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C J","family":"Freemantle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E A","family":"Haan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1990,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00390430","article-title":"Preferential derivation of abnormal human G-group-like chromosomes from chromosome 15","volume":"36","author":"Schreck, R.R.; Breg, W.R.; Erlanger, B.F.; Miller, O.J.","year":"1977","unstructured":"Schreck RR, Breg WR, Erlanger BF, Miller OJ. Preferential derivation of abnormal human G-group-like chromosomes from chromosome 15. Hum Genet 1977;36:1-12.","journal-title":"Hum Genet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF00399391","article-title":"Cytogenetic and clinical studies in five cases of inv dup(15)","volume":"50","author":"Wisniewski, L.; Hassold, T.; Heffelfinger, J.; Higgins, J.V.","year":"1979","unstructured":"Wisniewski L, Hassold T, Heffelfinger J, Higgins JV. Cytogenetic and clinical studies in five cases of inv dup(15). Hum Genet 1979;50:259-70.","journal-title":"Hum Genet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0168-9525(87)90232-0","article-title":"Hierarchical order in chromosome-specific human alpha satellite DNA","volume":"3","author":"Willard, H.F.; Waye, J.S.","year":"1987","unstructured":"Willard HF, Waye JS. Hierarchical order in chromosome-specific human alpha satellite DNA. 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Two subsets of human alphoid repetitive DNA show distinct preferential localization in the pericentric regions of chromosomes 13, 18 and 21. Cytogenet Cell Genet 1986;41:193-201.","journal-title":"Cytogenet Cell Genet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1089\/dna.1987.6.297","article-title":"Genomic organisation of human centromeric alpha satellite DNA: characterization of a chromosome 17 alpha satellite sequence","volume":"6","year":"1987","unstructured":"Choo KH, Brown R, Webb G. Craig 1W, Filby RG. Genomic organisation of human centromeric alpha satellite DNA: characterization of a chromosome 17 alpha satellite sequence. 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