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In the absence of cleft lip\/palate, EEC patients have a characteristic facial morphology with maxillary hypoplasia, short philtrum, and broad nasal tip.<\/jats:p>","DOI":"10.1136\/jmg.27.3.165","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:11:11Z","timestamp":1226329871000},"page":"165-168","source":"Crossref","is-referenced-by-count":19,"title":["EEC syndrome without ectrodactyly: report of two new families."],"prefix":"10.1136","volume":"27","author":[{"given":"J P","family":"Fryns","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Legius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Dereymaeker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Van den Berghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1990,3,1]]},"reference":[{"key":"ref_1","article-title":"Ueber eine sehr Complicirte Hasenscharte oder einen sogenannten Wolfsrachen mit einer an demselben Subjekte befndlichen merkwurdigen Misstaltung der Hande und Fusse","author":"Eckoldt, J.G.; Martens, F.H.","year":"1804","unstructured":"Eckoldt JG, Martens FH. Ueber eine sehr Complicirte Hasenscharte oder einen sogenannten Wolfsrachen mit einer an demselben Subjekte befndlichen merkwurdigen Misstaltung der Hande und Fusse. Leipzig: Steinacker, 1804."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1001\/archpedi.1970.02100070104016","article-title":"Association of ectrodactyly, ectodermal dysplasia, and cleft lip-palate","volume":"120","author":"Rudiger, R.A.; Haase, W.; Passarge, E.","year":"1970","unstructured":"Rudiger RA, Haase W, Passarge E. Association of ectrodactyly, ectodermal dysplasia, and cleft lip-palate. Am J Dis Child 1970;120:160-3.","journal-title":"Am J Dis Child"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1399-0004.1972.tb01461.x","article-title":"The syndrome of ectrodactyly, ectodermal dysplasia and cleft lip and palate: report of a family demonstrating a dominant inheritance pattern","volume":"3","author":"Brill, C.B.; Hsu, L.Y.F.; Hirschhorn, K.","year":"1972","unstructured":"Brill CB, Hsu LYF, Hirschhorn K. The syndrome of ectrodactyly, ectodermal dysplasia and cleft lip and palate: report of a family demonstrating a dominant inheritance pattern. Clin Genet 1972;3:295-302.","journal-title":"Clin Genet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF00440361","article-title":"Spalthand und Spaitfuss, ektodermale Dysplasie und Lippen-Kiefer-Gaumen-Spalate: ein autosomaldominant vererbtes Syndrom","volume":"115","author":"Pfeiffer, R.A.; Verbeck, C.","year":"1973","unstructured":"Pfeiffer RA, Verbeck C. Spalthand und Spaitfuss, ektodermale Dysplasie und Lippen-Kiefer-Gaumen-Spalate: ein autosomaldominant vererbtes Syndrom. Z Kinderheilkd 1973;115:235-44.","journal-title":"Z Kinderheilkd"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1399-0004.1972.tb01724.x","article-title":"The ectrodactylyectodermal dysplasia-clefting (EEC) syndrome","volume":"3","author":"Bixler, D.; Spivack, J.; Bennett, J.; Christian, J.C.","year":"1972","unstructured":"Bixler D, Spivack J, Bennett J, Christian JC. The ectrodactylyectodermal dysplasia-clefting (EEC) syndrome. Clin Genet 1972;3:43-51.","journal-title":"Clin Genet"},{"key":"ref_6","first-page":"125","article-title":"Genetic characteristics of the EEC syndrome","volume":"12","author":"Lurie, IV, Lazyuk; GI, Usova; Y.I.","year":"1976","unstructured":"Lurie IV, Lazyuk GI, Usova YI. Genetic characteristics of the EEC syndrome. Genetika 1976;12:125-31.","journal-title":"Genetika"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1136\/jmg.13.4.281","article-title":"Ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome: dominant inheritance and variable expression","volume":"13","author":"Penchaszadeh, V.B.; de Negrotti, T.C.","year":"1976","unstructured":"Penchaszadeh VB, de Negrotti TC. Ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome: dominant inheritance and variable expression. J Med Genet 1976;13:281-4.","journal-title":"J Med Genet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1399-0004.1985.tb00372.x","article-title":"EEC syndrome without ectrodactyly?","volume":"28","author":"Kuster, W.; Majewski, F.; Meinecke, P.","year":"1985","unstructured":"Kuster W, Majewski F, Meinecke P. EEC syndrome without ectrodactyly? Clin Genet 1985;28:130-5.","journal-title":"Clin Genet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1399-0004.1988.tb03412.x","article-title":"EEC syndrome sine sine? Report of a family with oligosymptomatic EEC syndrome","volume":"33","author":"Majewski, F.; Kuster, W.","year":"1988","unstructured":"Majewski F, Kuster W. EEC syndrome sine sine? Report of a family with oligosymptomatic EEC syndrome. 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