{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:49:42Z","timestamp":1790700582898,"version":"4.1.0"},"reference-count":27,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1990,7]]},"abstract":"<jats:p>We have examined chromosome aberrations in gamma irradiated (3 Gy) lymphocytes from five patients with Alzheimer's disease (AD). In each case, the number of dicentrics was significantly higher than the number in irradiated lymphocytes from five age matched normal subjects, the mean value for AD cells being about 25% higher. There was no significant difference in number of acentrics between AD and normal cells. Examination of the number of first, second, and third division metaphases, using fluorescence plus Giemsa staining, indicated that there was no difference in cycling time between AD and normal cells, and that after irradiation both groups showed the same mitotic delay. The similarity of our findings to those of others with irradiated Down's syndrome cells (from adult patients) is discussed.<\/jats:p>","DOI":"10.1136\/jmg.27.7.437","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:11:11Z","timestamp":1226329871000},"page":"437-440","source":"Crossref","is-referenced-by-count":18,"title":["Chromosomal radiosensitivity of lymphocytes from Alzheimer's disease patients."],"prefix":"10.1136","volume":"27","author":[{"given":"S E","family":"Tobi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J E","family":"Moquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A A","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D C","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R F","family":"Itzhaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1990,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0140-6736(83)91461-7","article-title":"Radiosensitivity in Alzheimer disease and Parkinson disease","volume":"i:","author":"Robbins, J.H.; Otsuka, F.; Tarone, R.E.","year":"1983","unstructured":"Robbins JH, Otsuka F, Tarone RE, et al. 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Alutat Res 1986;173: 127-30.","journal-title":"7 Med Genet; Mitomycin C and ethyl methanesulphonate-induced sister-chromatid exchanges in lvmphocvtes from individuals with Alzheimer's pre-senile dementia"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0197-4580(88)80088-5","article-title":"Sister chromatid exchanges and dementia of the Alzheimer type","volume":"9","author":"Matsuvama, S.S.; Fu, T.K.","year":"1988","unstructured":"Matsuvama SS, Fu TK. Sister chromatid exchanges and dementia of the Alzheimer type. Neurobiol Aging 1988;9:405-8.","journal-title":"Neurobiol Aging"},{"key":"ref_14","first-page":"319","article-title":"Sister chromatid exchanges and cell cvcle kinetics in Alzheimer's disease","volume":"19","author":"Fischman, H.K.; Reisberg, B.; Albur, P.; Rainer, J.D.","year":"1984","unstructured":"Fischman HK, Reisberg B, Albur P, Rainer JD. Sister chromatid exchanges and cell cvcle kinetics in Alzheimer's disease. 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Mutat Res 1970;10:617-33.","journal-title":"Mutat Res"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1203\/00006450-197205000-00005","article-title":"In vitro chromosomal radiosensitivity in patients and in carriers with abnormal non-Down's syndrome karyotypes","volume":"6","author":"Higurashi, M.; Conen, P.E.","year":"1972","unstructured":"Higurashi M, Conen PE. In vitro chromosomal radiosensitivity in patients and in carriers with abnormal non-Down's syndrome karyotypes. Pediatr Res 1972;6:514-20.","journal-title":"Pediatr Res"},{"key":"ref_25","first-page":"1499","article-title":"Proliferative kinetics and chromosome damage in trisomy 21 lymphocyte cultures exposed to y-rays and bleomycin","volume":"44","author":"Morimoto, K.; Kaneko, T.; Iijima, K.; Koizumi, A.","year":"1984","unstructured":"Morimoto K, Kaneko T, Iijima K, Koizumi A. Proliferative kinetics and chromosome damage in trisomy 21 lymphocyte cultures exposed to y-rays and bleomycin. 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Mutat Res 1985;150:277-82.","journal-title":"Mutat Res"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.27.7.437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:38:07Z","timestamp":1760769487000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.27.7.437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,7]]},"references-count":27,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1990,7,1]]},"published-print":{"date-parts":[[1990,7]]}},"alternative-id":["10.1136\/jmg.27.7.437"],"URL":"https:\/\/doi.org\/10.1136\/jmg.27.7.437","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"value":"0022-2593","type":"print"},{"value":"1468-6244","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,7]]}}}