{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T13:03:49Z","timestamp":1787144629867,"version":"build-2736575974"},"reference-count":9,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1991,11]]},"abstract":"<jats:p>We present a male infant with cranial hemi-hypertrophy, a lymphangioma, a lipoma, and epidermal naevi. A diagnosis of Proteus syndrome was made. His father had had a large lymphangioma resected from the right side of the face as a child. We propose that Proteus syndrome has been transmitted from father to son.<\/jats:p>","DOI":"10.1136\/jmg.28.11.781","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:11:11Z","timestamp":1226329871000},"page":"781-785","source":"Crossref","is-referenced-by-count":34,"title":["Transmission of Proteus syndrome from father to son?"],"prefix":"10.1136","volume":"28","author":[{"given":"J","family":"Goodship","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Redfearn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Milligan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Gardner-Medwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Burn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1991,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/BF00661895","article-title":"The Proteus syndrome","volume":"140","author":"Wiedemann, H.R.; Burgio, G.R.; Aldenhoff, P.; Kunze, J.; Kaufmann, H.J.; Schirg, E.","year":"1983","unstructured":"Wiedemann HR, Burgio GR, Aldenhoff P, Kunze J, Kaufmann HJ, Schirg E. The Proteus syndrome. Eur J Pediatr 1983;140:5-12.","journal-title":"Eur J Pediatr"},{"key":"ref_2","first-page":"260","article-title":"Understanding Proteus syndrome, unmasking the elephant man, and stemming elephant fever","volume":"1","author":"Cohen, M.M.","year":"1988","unstructured":"Cohen MM. Understanding Proteus syndrome, unmasking the elephant man, and stemming elephant fever. Neurofibromatosis 1988;1:260-80.","journal-title":"Neurofibromatosis"},{"key":"ref_3","first-page":"315","article-title":"Klippel-Trenaunay-Weber syndrome","volume":"7","author":"Horton, W.A.","year":"1971","unstructured":"Horton WA. Klippel-Trenaunay-Weber syndrome. Birth Defects 1971;7:315-8.","journal-title":"Birth Defects"},{"key":"ref_4","first-page":"87","article-title":"Proteus syndrome and hamartoses with overgrowth. Dysmorphol Clin Genet","volume":"4","author":"Hotamisligil, G.S.","year":"1990","unstructured":"Hotamisligil GS. Proteus syndrome and hamartoses with overgrowth. Dysmorphol Clin Genet 1990;4:87-102."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ajmg.1320250229","article-title":"Encephalocraniocutaneous lipomatosis and proteus syndrome","volume":"25","author":"Wiedemann, H.R.; Burgio, G.R.","year":"1986","unstructured":"Wiedemann HR, Burgio GR. Encephalocraniocutaneous lipomatosis and proteus syndrome. Am J Med Genet 1986; 25:403-4.","journal-title":"Am J Med Genet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/ajmg.1320270111","article-title":"Proteus syndrome: an expanded phenotype","volume":"27","author":"Clark, R.D.; Donnai, D.; Rogers, J.; Cooper, J.; Baraitser, M.","year":"1987","unstructured":"Clark RD, Donnai D, Rogers J, Cooper J, Baraitser M. Proteus syndrome: an expanded phenotype. Am J Med Genet 1987;27:99-1 17.","journal-title":"Am J Med Genet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/ajmg.1320310434","article-title":"Report of a case resembling the Proteus syndrome with a chromosome abnormality","volume":"31","author":"Say, B.; Carpenter, N.J.","year":"1988","unstructured":"Say B, Carpenter NJ. Report of a case resembling the Proteus syndrome with a chromosome abnormality. Am J Med Genet 1988;31:987-9.","journal-title":"Am J Med Genet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0190-9622(87)80249-9","article-title":"Lethal genes surviving by mosaicism: a possible explanation for sporadic birth defects involving the skin","volume":"16","author":"Happle, R.","year":"1987","unstructured":"Happle R. Lethal genes surviving by mosaicism: a possible explanation for sporadic birth defects involving the skin. J Am Acad Dermatol 1987;16:899-906.","journal-title":"J Am Acad Dermatol"},{"key":"ref_9","first-page":"1034","article-title":"Variable expression of osteogenesis imperfecta in a nuclear family is explained by somatic mosaicism for a lethal point mutation in the alphaI(I) gene (COLIAI) of type I collagen in a parent","volume":"46","author":"Wallis, G.A.; Starman, B.J.; Zinn, A.B.; Byers, P.H.","year":"1990","unstructured":"Wallis GA, Starman BJ, Zinn AB, Byers PH. Variable expression of osteogenesis imperfecta in a nuclear family is explained by somatic mosaicism for a lethal point mutation in the alphaI(I) gene (COLIAI) of type I collagen in a parent. 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