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Knowledge of the genetic risk had a different effect on reproductive behaviour in the 1950s from that in later years. The difference was attributed both to the influence of cultural factors and to technical, therapeutic, and diagnostic advances.<\/jats:p>","DOI":"10.1136\/jmg.28.8.523","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:11:11Z","timestamp":1226329871000},"page":"523-529","source":"Crossref","is-referenced-by-count":5,"title":["Reproductive behaviour of families segregating for Cooley's anaemia before and after the availability of prenatal diagnosis."],"prefix":"10.1136","volume":"28","author":[{"given":"M R","family":"Gamberini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Lucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Vullo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Canella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Barrai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1991,8,1]]},"reference":[{"key":"ref_1","first-page":"27","article-title":"I1 rilievo della patologia cranica nella pratica pediatrica","volume":"13","author":"Vullo, C.; Di Palma, A.; Atti, G.; Luciani, L.","year":"1985","unstructured":"Vullo C, Di Palma A, Atti G, Luciani L. I1 rilievo della patologia cranica nella pratica pediatrica. Crescita 1985;13:27-32.","journal-title":"Crescita"},{"key":"ref_2","first-page":"553","article-title":"The destiny of patients affected by thalassaemia major","volume":"14","author":"Vullo, C.; Argiolu, F.; Borgatti, L.","year":"1988","unstructured":"Vullo C, Argiolu F, Borgatti L, et al. The destiny of patients affected by thalassaemia major. Riv Ital Pediatr 1988;14: 553-64.","journal-title":"Riv Ital Pediatr"},{"key":"ref_3","article-title":"The thalassaemia syndromes","author":"Weatherall, D.J.; Clegg, J.B.","year":"1981","unstructured":"Weatherall DJ, Clegg JB. The thalassaemia syndromes. Oxford: Blackwell Scientific Publications, 1981."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/ajmg.1320060304","article-title":"Assessment of prospective genetic counseling in the Ferrara area","volume":"6","author":"Barrai, I.; Vullo, C.","year":"1980","unstructured":"Barrai I, Vullo C. 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Effect of introducing antenatal diagnosis on reproductive behaviour of families at risk for thalassaemia major. Br MedJ3 1980;280:1347-50."},{"article-title":"Istituto Centrale di Statistica (ISTAT). Roma: Annuario Statistico Italiano Edizione","year":"1983","key":"ref_7","unstructured":"Istituto Centrale di Statistica (ISTAT). Roma: Annuario Statistico Italiano Edizione, 1983."}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.28.8.523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T18:52:37Z","timestamp":1759690357000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.28.8.523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,8]]},"references-count":7,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1991,8,1]]},"published-print":{"date-parts":[[1991,8]]}},"alternative-id":["10.1136\/jmg.28.8.523"],"URL":"https:\/\/doi.org\/10.1136\/jmg.28.8.523","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"type":"print","value":"0022-2593"},{"type":"electronic","value":"1468-6244"}],"subject":[],"published":{"date-parts":[[1991,8]]}}}