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In three examples of structural rearrangements the potential use of the 'chromosome painting' method is assessed for its ability to enhance the routine cytogenetic service currently available.<\/jats:p>","DOI":"10.1136\/jmg.28.9.577","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:11:11Z","timestamp":1226329871000},"page":"577-582","source":"Crossref","is-referenced-by-count":23,"title":["Chromosome in situ suppression hybridisation in clinical cytogenetics."],"prefix":"10.1136","volume":"28","author":[{"given":"M A","family":"Hulten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C P","family":"Gould","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A S","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"Waters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1991,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF01790091","article-title":"Detection of chromosome aberrations in metaphase and interphase tumour cells by in-situ hybridization using chromosome-specific library probes","volume":"80","author":"Cremer, T.; Lichter, P.; Borden, J.; Ward, D.C.; Manuelidis, L.","year":"1988","unstructured":"Cremer T, Lichter P, Borden J, Ward DC, Manuelidis L. Detection of chromosome aberrations in metaphase and interphase tumour cells by in-situ hybridization using chromosome-specific library probes. Hum Genet 1988;80:235-46.","journal-title":"Hum Genet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/BF01790090","article-title":"Delineation of individual human chromosomes in metaphase and interphase cells by in-situ suppression hybridization using recombinant DNA libraries","volume":"80","author":"Lichter, P.; Cremer, T.; Borden, J.; Manuelidis, L.; Ward, D.C.","year":"1988","unstructured":"Lichter P, Cremer T, Borden J, Manuelidis L, Ward DC. Delineation of individual human chromosomes in metaphase and interphase cells by in-situ suppression hybridization using recombinant DNA libraries. Hum Genet 1988;80:224-34.","journal-title":"Hum Genet"},{"key":"ref_3","first-page":"9664","article-title":"Rapid detection of chromosome 21 aberrations","volume-title":"by in-situ hybridization. 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Proc Natl Acad Sci USA 1988;85:9138-42."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000132972","article-title":"Detection of Philadelphia chromosome in interphase nuclei","volume":"54","author":"Arnoldus, E.P.J.; Wiegant, J.; Noordermeer, I.A.","year":"1990","unstructured":"Arnoldus EPJ, Wiegant J, Noordermeer IA, et al. Detection of Philadelphia chromosome in interphase nuclei. Cytogenet Cell Genet 1990;54:108-1 1.","journal-title":"Cytogenet Cell Genet"},{"key":"ref_6","first-page":"145","article-title":"Chromosomal in-situ suppression hybridization ofhuman gonosomes and autosomes and its use in clinical cytogenetics","volume":"85","author":"Jauch, A.; Oaumer, C.; Lichter, P.","year":"1990","unstructured":"Jauch A, Oaumer C, Lichter P, et al. Chromosomal in-situ suppression hybridization ofhuman gonosomes and autosomes and its use in clinical cytogenetics. 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Genomics 1991;9:355-61."}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.28.9.577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T17:27:44Z","timestamp":1760722064000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.28.9.577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,9]]},"references-count":8,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1991,9,1]]},"published-print":{"date-parts":[[1991,9]]}},"alternative-id":["10.1136\/jmg.28.9.577"],"URL":"https:\/\/doi.org\/10.1136\/jmg.28.9.577","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"type":"print","value":"0022-2593"},{"type":"electronic","value":"1468-6244"}],"subject":[],"published":{"date-parts":[[1991,9]]}}}