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In 48 sets of affected sibs the lesions were separable into high NTD, which had involvement above vertebral level T12, and low NTD, which did not extend above T12. Low lesions comprised a minority of the total and each one occurred in a sibship with a high lesion. These results do not support the idea that NTDs occurring above and below vertebral level T12 have a different genetic basis.<\/jats:p>","DOI":"10.1136\/jmg.28.9.605","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:11:11Z","timestamp":1226329871000},"page":"605-608","source":"Crossref","is-referenced-by-count":24,"title":["Do familial neural tube defects breed true?"],"prefix":"10.1136","volume":"28","author":[{"given":"E","family":"Drainer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H M","family":"May","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Tolmie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1991,9,1]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Unanswered questions on neural tube defects","volume":"294","author":"Seller, M.J.","year":"1980","unstructured":"Seller MJ. 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