{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T17:10:08Z","timestamp":1760721008318,"version":"build-2065373602"},"reference-count":13,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:p>Seventy-two fetuses or neonates with non-immune hydrops were examined between 1983 and 1988. The commonest association was chromosome abnormality; 11 fetuses had a 45,X karyotype and 11 autosomal trisomy. Chromosome abnormality was suspected in a further 20 on necropsy findings but chromosome culture was not possible or unsuccessful. In 11 cases there was histological evidence of infection; seven babies had major structural anomalies and six affected fetuses were twins. In six (8%) the cause of hydrops was not determined compared with eight (16%) of cases examined between 1976 and 1982. Hydrops was diagnosed more frequently while the fetus was alive, before 20 weeks' gestation, and associated with chromosome anomaly than found previously.<\/jats:p>","DOI":"10.1136\/jmg.29.2.91","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:23:16Z","timestamp":1226330596000},"page":"91-97","source":"Crossref","is-referenced-by-count":35,"title":["Fetal hydrops."],"prefix":"10.1136","volume":"29","author":[{"given":"P A","family":"Boyd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J W","family":"Keeling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1992,2,1]]},"reference":[{"key":"ref_1","first-page":"226","article-title":"The obstetric management of non-immunological hydrops. Br 3 Obstet Gynaecol","volume":"93","author":"Gough, J.D.; Keeling, J.W.; Castle, B.; Iliff, P.J.","year":"1986","unstructured":"Gough JD, Keeling JW, Castle B, Iliff PJ. The obstetric management of non-immunological hydrops. Br 3 Obstet Gynaecol 1986;93:226-34."},{"issue":"1","key":"ref_2","article-title":"The pathology of nonrhesus hydrops","volume":"1","author":"Keeling, J.W.; Gough, D.J.; Iliff, P.","year":"1983","unstructured":"Keeling JW, Gough DJ, Iliff P. The pathology of nonrhesus hydrops. Diagn Histopathol 1983;6:89-1 1 1.","journal-title":"Diagn Histopathol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-2990.1991.tb00691.x","article-title":"The incidence of prenatal brain injury","volume":"17","author":"Squier, M.V.; Keeling, J.W.","year":"1991","unstructured":"Squier MV, Keeling JW. The incidence of prenatal brain injury. Neuropathol Appl Neurobiol 1991;17:29-38.","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref_4","first-page":"429","article-title":"Hydrops fetalis and other forms of excess fluid collection in the fetus","volume-title":"Textbook of fetal and perinatal pathology","author":"Keeling, J.W.","year":"1990","unstructured":"Keeling JW. Hydrops fetalis and other forms of excess fluid collection in the fetus. In: Wigglesworth JS, Singer DB, eds. Textbook of fetal and perinatal pathology. Oxford: Blackwell Scientific Publications, 1990:429-54."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/ajmg.1320340313","article-title":"Hydrops revisited: literature review of 1,414 cases published in the 1980s","volume":"34","author":"Machin, G.A.","year":"1989","unstructured":"Machin GA. Hydrops revisited: literature review of 1,414 cases published in the 1980s. Ant _7 Med Genet 1989;34:366-90.","journal-title":"Ant _7 Med Genet"},{"key":"ref_6","first-page":"568","article-title":"Fetal echocardiography for evaluation of in utero congestive heart failure: a technique for study of nonimmune fetal hydrops. N Engl 3 Med","volume":"306","author":"Kleinman, C.S.; Donnerstein, R.L.; DeVore, G.R.","year":"1982","unstructured":"Kleinman CS, Donnerstein RL, DeVore GR, et al. Fetal echocardiography for evaluation of in utero congestive heart failure: a technique for study of nonimmune fetal hydrops. N Engl 3 Med 1982;306:568-75."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1136\/bmj.297.6641.107","article-title":"Obstetric importance, diagnosis, and management of fetal tachycardias","volume":"297","author":"Maxwell, D.J.; Crawford, D.C.; Curry, P.V.M.; Tynan, M.J.; Allan, L.D.","year":"1988","unstructured":"Maxwell DJ, Crawford DC, Curry PVM, Tynan MJ, Allan LD. Obstetric importance, diagnosis, and management of fetal tachycardias. BMJ 1988;297:107-10.","journal-title":"BMJ"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3109\/15513818909022328","article-title":"Cardiac abnormalities and nonimmune hydrops fetalis: a coincidental, not causal, relationship","volume":"9","author":"McFadden, D.E.; Taylor, G.P.","year":"1989","unstructured":"McFadden DE, Taylor GP. Cardiac abnormalities and nonimmune hydrops fetalis: a coincidental, not causal, relationship. Pediatr Pathol 1989;9:11-17.","journal-title":"Pediatr Pathol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1136\/adc.58.12.979","article-title":"Non-immunologic hydrops fetalis: a review of 27 cases","volume":"58","author":"IliffPJ, Nicholls A.; JW, Keeling; JD, Gough","year":"1983","unstructured":"IliffPJ, Nicholls A, Keeling JW, Gough JD. Non-immunologic hydrops fetalis: a review of 27 cases. Arch Dis Child 1983;58:979-82.","journal-title":"Arch Dis Child"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1136\/jcp.41.4.381","article-title":"Parvovirus as a cause of hydrops fetalis: detection by in situ DNA hybridisation","volume":"41","author":"Porter, H.J.; Khong, T.Y.; Evans, M.F.; Chan, V.T.W.; Fleming, K.A.","year":"1988","unstructured":"Porter HJ, Khong TY, Evans MF, Chan VTW, Fleming KA. Parvovirus as a cause of hydrops fetalis: detection by in situ DNA hybridisation. J Clin Pathol 1988;41:381-3.","journal-title":"J Clin Pathol"},{"key":"ref_11","first-page":"589","article-title":"Antenatal evaluation and management in nonimmune hydrops fetalis","volume":"67","author":"Watson, I.; Campbell, S.","year":"1986","unstructured":"Watson I, Campbell S. Antenatal evaluation and management in nonimmune hydrops fetalis. Obstet Gynecol 1986;67:589-93.","journal-title":"Obstet Gynecol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1515\/jpme.1988.16.2.133","article-title":"Intrauterine treatment of idiopathic hydrops fetalis","volume":"16","author":"Shimokawa, H.; Maeda, H.; Miyamoto, S.; Koyanagi, T.; Nakano, H.","year":"1988","unstructured":"Shimokawa H, Maeda H, Miyamoto S, Koyanagi T, Nakano H. Intrauterine treatment of idiopathic hydrops fetalis. J Perinat Med 1988;16:133-8.","journal-title":"J Perinat Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1159\/000324188","article-title":"Intrauterine anoxic brain damage in nonimmune hydrops fetalis","volume":"49","author":"Kobori, J.A.; Urich, H.","year":"1986","unstructured":"Kobori JA, Urich H. Intrauterine anoxic brain damage in nonimmune hydrops fetalis. Biol Neonate 1986;49:311-7.","journal-title":"Biol Neonate"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.29.2.91","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T16:52:35Z","timestamp":1760719955000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.29.2.91"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1992,2,1]]},"published-print":{"date-parts":[[1992,2]]}},"alternative-id":["10.1136\/jmg.29.2.91"],"URL":"https:\/\/doi.org\/10.1136\/jmg.29.2.91","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"type":"print","value":"0022-2593"},{"type":"electronic","value":"1468-6244"}],"subject":[],"published":{"date-parts":[[1992,2]]}}}