{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:19:01Z","timestamp":1789201141222,"version":"build-2803163510"},"reference-count":17,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1992,4]]},"abstract":"<jats:p>Age related genetic risk data for carrying the gene for Huntington's disease in relatives at risk, based on a previously documented life table approach, are presented in a form allowing ready access for use in genetic counselling. Figures are given for first degree relatives and for second degree relatives showing varying age combinations of consultand and intervening parent at risk. Data are also given for the risk of developing Huntington's disease over varying finite periods in relation to age. The availability of this information in tabular form should help those involved in genetic counselling for this disorder in providing accurate risk estimates to relatives; the data are also of importance for combination with genotype information in predictive testing.<\/jats:p>","DOI":"10.1136\/jmg.29.4.239","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:23:16Z","timestamp":1226330596000},"page":"239-242","source":"Crossref","is-referenced-by-count":31,"title":["Age at onset and life table risks in genetic counselling for Huntington's disease."],"prefix":"10.1136","volume":"29","author":[{"given":"P S","family":"Harper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R G","family":"Newcombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1992,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1469-1809.1981.tb00351.x","article-title":"A life table for onset of Huntington's chorea","volume":"45","author":"Newcombe, R.G.","year":"1981","unstructured":"Newcombe RG. 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Eine populationsgenetische Studie","author":"Wendt, G.G.; Drohm, D.","year":"1972","unstructured":"Wendt GG, Drohm D. Die Huntingtonsche Chorea. Eine populationsgenetische Studie. Stuttgart: Thieme, 1972."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/S0022-3476(83)80480-6","article-title":"Outlook for a clinically normal child in a sibship with congenital myotonic dystrophy","volume":"103","author":"O'Brien, T.; Newcombe, R.G.; Harper, P.S.","year":"1983","unstructured":"O'Brien T, Newcombe RG, Harper PS. Outlook for a clinically normal child in a sibship with congenital myotonic dystrophy. Pediatr 1983;103:762-3.","journal-title":"Pediatr"},{"key":"ref_6","article-title":"Practical genetic counselling","author":"Harper, P.S.","year":"1988","unstructured":"Harper PS. Practical genetic counselling. 3rd ed. London: Wright, 1988.","edition":"3rd ed"},{"key":"ref_7","article-title":"Genetics of neurological disorders","author":"Baraitser, M.","year":"1990","unstructured":"Baraitser M. Genetics of neurological disorders. Oxford: Oxford University Press, 1990."},{"key":"ref_8","first-page":"601","article-title":"Problems in genetic prediction for Huntington's disease","volume":"ii:","author":"Morris, M.J.; Tyler, A.; Lazarou, L.; Meredith, L.; Harper, P.S.","year":"1989","unstructured":"Morris MJ, Tyler A, Lazarou L, Meredith L, Harper PS. Problems in genetic prediction for Huntington's disease. Lancet 1989;ii:601-3.","journal-title":"Lancet"},{"key":"ref_9","article-title":"Predictive testing for Huntington's disease","author":"Harper, P.S.; Morris, M.","year":"1991","unstructured":"Harper PS, Morris M. Predictive testing for Huntington's disease. In: Harper PS, ed. Huntington's disease. 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Clin Genet 1990;38: 180-6.","journal-title":"Clin Genet"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/mds.870050202","article-title":"Huntington's disease in Venezuela: 7 years of follow-up on symptomatic and asymptomatic individuals","volume":"5","author":"Penney, J.B.; Young, A.B.; Shoulson, I.","year":"1990","unstructured":"Penney JB, Young AB, Shoulson I. Huntington's disease in Venezuela: 7 years of follow-up on symptomatic and asymptomatic individuals. 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