{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:45:23Z","timestamp":1791121523162,"version":"4.1.0"},"reference-count":11,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:p>A population based and validated 10 year cohort of 94 cases with split hand\/foot born in Hungary, 1975-1984 was evaluated. This type of congenital limb deficiency was relatively frequently (43%) associated with non-limb defects. Fifty-four cases with isolated split hand\/foot are evaluated in this paper. A single limb was affected in 78% of cases. The upper limbs were 21 times more frequently affected in unimelic cases with a right sided predominance and male excess. Case-control analysis indicated intrauterine growth retardation and lower socioeconomic status of parents of cases. Family study showed six familial cases with autosomal dominant inheritance among 152 first and 452 second degree relatives. All familial cases were males.<\/jats:p>","DOI":"10.1136\/jmg.30.7.593","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:23:16Z","timestamp":1226330596000},"page":"593-596","source":"Crossref","is-referenced-by-count":30,"title":["An epidemiological study of isolated split hand\/foot in Hungary, 1975-1984."],"prefix":"10.1136","volume":"30","author":[{"given":"A E","family":"Czeizel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Vit\u00e9z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Kodaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Lenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1993,7,1]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Birth prevalence of different congenital limb deficiency types in a populationbased revised Hungarian material 1975-1984","volume":"39","author":"Czeizel, A.; Vitez, M.; Kodaj, I.; Lenz, W.","year":"1991","unstructured":"Czeizel A, Vitez M, Kodaj I, Lenz W. 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Grundsatzlicher uber die Beurteilung der Entstehung und Bewertung atypischer Handund Fussmissbildungen. Z Orthop 1937;66:80-8.","journal-title":"Z Orthop"},{"key":"ref_5","article-title":"Congenital abnormalities associated with limb reduction deficiencies: a populationbased Hungarian study","author":"Evans, J.A.; Vitez, M.; Czeizel, A.","year":"1975","unstructured":"Evans JA, Vitez M, Czeizel A. Congenital abnormalities associated with limb reduction deficiencies: a populationbased Hungarian study, 1975-1984. AmJ7 Med Genet (in press)."},{"key":"ref_6","first-page":"219","article-title":"The activities of the Hungarian Centre for Congenital Anomaly Control. WHO Stat Rep Quart","volume":"41","author":"Czeizel, A.","year":"1988","unstructured":"Czeizel A. The activities of the Hungarian Centre for Congenital Anomaly Control. WHO Stat Rep Quart 1988;41:219-27."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/oxfordjournals.aje.a112531","article-title":"Multivariate analysis for matched case-control studies","volume":"107","author":"Holford, T.R.; White, C.; Kelsey, J.L.","year":"1978","unstructured":"Holford TR, White C, Kelsey JL. Multivariate analysis for matched case-control studies. Am 7 Epidemiol 1978;107:245-2.","journal-title":"Am 7 Epidemiol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF00591081","article-title":"X-chromosomally inherited split-hand\/split foot anomaly in a Pakistani kindred","volume":"75","author":"Ahmad, M.; Abbas, H.; Haque, S.; Flatz, G.","year":"1987","unstructured":"Ahmad M, Abbas H, Haque S, Flatz G. X-chromosomally inherited split-hand\/split foot anomaly in a Pakistani kindred. Hum Genet 1987;75:169-73.","journal-title":"Hum Genet"},{"issue":"24","key":"ref_9","first-page":"89","article-title":"Ectrodactyly-evidence in favour of a disturbed segregation in the offspring of affected males","volume":"1960","author":"Stevenson, A.C.; Jennings, L.M.","unstructured":"Stevenson AC, Jennings LM. Ectrodactyly-evidence in favour of a disturbed segregation in the offspring of affected males. Ann Hum Genet 1960;24:89-96.","journal-title":"Ann Hum Genet"},{"key":"ref_10","first-page":"202","article-title":"Anomalous inheritance in a kindred with split hand, split foot malformations","volume":"147","author":"Spranger, M.; Schapera, J.","year":"1988","unstructured":"Spranger M, Schapera J. Anomalous inheritance in a kindred with split hand, split foot malformations. Eur 7 Pediatr 1988;147:202-5."},{"key":"ref_11","first-page":"299","article-title":"The vascular pathogenesis of some sporadically occurring limb defects","volume":"7","author":"Hoyme, H.E.; van Allen, M.I.; Jones, K.L.","year":"1983","unstructured":"Hoyme HE, van Allen MI, Jones KL. The vascular pathogenesis of some sporadically occurring limb defects. 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