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A wide range of phenotypic severity is apparent, from disabling ectopic bone formation and premature death to an asymptomatic adult with characteristic big toe malformations.<\/jats:p>","DOI":"10.1136\/jmg.30.8.687","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:23:16Z","timestamp":1226330596000},"page":"687-689","source":"Crossref","is-referenced-by-count":57,"title":["A three generation family with fibrodysplasia ossificans progressiva."],"prefix":"10.1136","volume":"30","author":[{"given":"J M","family":"Connor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Skirton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P W","family":"Lunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1993,8,1]]},"reference":[{"key":"ref_1","first-page":"603","article-title":"Connective tissue and its heritable disorders. 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A clinical and pathologic study","volume":"50","author":"Eaton, W.L.; Conkling, W.S.; Daeschner, C.W.","year":"1957","unstructured":"Eaton WL, Conkling WS, Daeschner CW. Early myositis ossificans progressiva occurring in homozygotic twins. A clinical and pathologic study. J Pediatr 1957;50:591-8.","journal-title":"J Pediatr"},{"key":"ref_4","first-page":"204","article-title":"Myositis ossificans progressiva in homozygotic twins","volume":"59","year":"1948","unstructured":"Vastine JH, Vastine MF, Arango 0. Myositis ossificans progressiva in homozygotic twins. AJR 1948;59:204-12.","journal-title":"AJR"},{"key":"ref_5","first-page":"320","article-title":"Zur Genetik der Myositis ossificans progressiva","volume":"4","author":"Tunte, W.; Becker, P.E.; von Knorre, G.V.","year":"1967","unstructured":"Tunte W, Becker PE, von Knorre GV. Zur Genetik der Myositis ossificans progressiva. 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Klin Med (Mosk) 1964;42:106-10.","journal-title":"Klin Med (Mosk)"},{"issue":"10","key":"ref_9","first-page":"37","article-title":"Discussion in meeting in West London MedicoChirurgical Society","volume":"1905","author":"Gaster, A.","year":"1904","unstructured":"Gaster A. Discussion in meeting in West London MedicoChirurgical Society, 7 October 1904. West London MedJ7 1905;10:37.","journal-title":"West London MedJ7"},{"key":"ref_10","first-page":"76","article-title":"Fibrodysplasia ossificans progressiva. The clinical features and natural history of 34 patients","volume":"64","author":"Connor, J.M.; Evans, D.A.P.","year":"1982","unstructured":"Connor JM, Evans DAP. Fibrodysplasia ossificans progressiva. The clinical features and natural history of 34 patients. J BoneJoint Surg (Br) 1982;64:76-83.","journal-title":"J BoneJoint Surg (Br)"},{"key":"ref_11","first-page":"119","article-title":"Fibrodysplasia ossificans progressiva","volume":"22","author":"Hall, C.M.; Sutcliffe, J.","year":"1979","unstructured":"Hall CM, Sutcliffe J. Fibrodysplasia ossificans progressiva. Ann Radiol (Paris) 1979;22:119-23.","journal-title":"Ann Radiol (Paris)"},{"key":"ref_12","first-page":"492","article-title":"The cervical spine in fibrodysplasia ossificans progressiva","volume":"55","author":"Connor, J.M.; Smith, R.","year":"1982","unstructured":"Connor JM, Smith R. The cervical spine in fibrodysplasia ossificans progressiva. Br I Radiol 1982;55:492-6."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"792","DOI":"10.2106\/00004623-197759060-00013","article-title":"Synovial osteochondromatosis: a histopathological study of 30 cases","volume":"59","author":"Milgram, J.W.","year":"1977","unstructured":"Milgram JW. 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