{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:20:06Z","timestamp":1760833206342,"version":"build-2065373602"},"reference-count":27,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:p>Wilms' tumour of the kidney is known to occur in Beckwith-Wiedemann syndrome. It has also been described in four cancer prone families displaying Li-Fraumeni syndrome but it is not usually considered to be part of this syndrome. In order to detect particular familial cancer aggregations associated with this tumour, we studied the cancer incidence and mortality among relatives of the 501 Wilms' tumour patients in the French Wilms' Tumour Study. We found no familial association with breast cancer or soft tissue sarcomas which are the most common cancers in the Li-Fraumeni syndrome. However, we found two significant familial associations of Wilms' tumour with bone cancers on the one hand and with brain tumours on the other hand. These associations could reflect a small proportion of families segregating for some susceptibility gene. This should then be confirmed at the molecular level.<\/jats:p>","DOI":"10.1136\/jmg.31.6.429","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:23:16Z","timestamp":1226330596000},"page":"429-434","source":"Crossref","is-referenced-by-count":13,"title":["The French Wilms' tumour study: no clear evidence for cancer prone families."],"prefix":"10.1136","volume":"31","author":[{"given":"C","family":"Moutou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hochez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Chompret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M F","family":"Tournade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Le Bihan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Zucker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Lemerle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Bona\u00efti-Pelli\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,6,1]]},"reference":[{"key":"ref_1","first-page":"17281","article-title":"Epidemiology of Wilms tumor","volume":"21","author":"Breslow, N.; Olshan, A.; Beckwith, J.B.; Green, D.M.","year":"1993","unstructured":"Breslow N, Olshan A, Beckwith JB, Green DM. Epidemiology of Wilms tumor. Med Pediatr Onicol 1993;21:17281.","journal-title":"Med Pediatr Onicol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1073\/pnas.68.4.820","article-title":"Mutation and cancer: statistical study of retinoblastoma","volume":"68","author":"Knudson, A.G.","year":"1971","unstructured":"Knudson AG. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 1971;68:820-3.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"ref_3","first-page":"13","article-title":"Mutation and cancer: a model for Wilms' tumor of the kidney","volume":"48","author":"Knudson, A.G.; Strong, L.C.","year":"1972","unstructured":"Knudson AG, Strong LC. Mutation and cancer: a model for Wilms' tumor of the kidney. _7 Natl Cancer Iist 1972;48:3 13-24."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1542\/peds.61.4.604","article-title":"Chromosomal imbalance in the aniridia-Wilms' tumor association: 1 lp interstitial deletion","volume":"61","author":"Riccardi, V.M.; Sujanski, E.; Smith, A.C.; Francke, U.","year":"1978","unstructured":"Riccardi VM, Sujanski E, Smith AC, Francke U. Chromosomal imbalance in the aniridia-Wilms' tumor association: 1 lp interstitial deletion. Pediatrics 1978;61:604-10.","journal-title":"Pediatrics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0168-9525(92)90019-Z","article-title":"Wilms' tumour: reconciling genetics and biology","volume":"8","author":"V, Van Heyningen; ND, Hastie","year":"1992","unstructured":"Van Heyningen V, Hastie ND. Wilms' tumour: reconciling genetics and biology. 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BitlI Canicer 1988;75:131-3.","journal-title":"BitlI Canicer"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.31.6.429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:57:25Z","timestamp":1760774245000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.31.6.429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,6]]},"references-count":27,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1994,6,1]]},"published-print":{"date-parts":[[1994,6]]}},"alternative-id":["10.1136\/jmg.31.6.429"],"URL":"https:\/\/doi.org\/10.1136\/jmg.31.6.429","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"type":"print","value":"0022-2593"},{"type":"electronic","value":"1468-6244"}],"subject":[],"published":{"date-parts":[[1994,6]]}}}