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This highlights the need for a full family history in apparently sporadic cases. Somatic mutations in p16, BRCA2, and APC have also been reported in pancreatic cancer; however, K-RAS mutations appear to be the commonest oncogenic alteration. Recent advances in our understanding of the basis of hereditary cancer syndromes may be applicable to the diagnosis, treatment, and possibly prevention of pancreatic adenocarcinoma in the future.<\/jats:p>","DOI":"10.1136\/jmg.33.11.889","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:37:21Z","timestamp":1226331441000},"page":"889-898","source":"Crossref","is-referenced-by-count":67,"title":["Pancreatic adenocarcinoma: epidemiology and genetics."],"prefix":"10.1136","volume":"33","author":[{"given":"T Y","family":"Flanders","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W D","family":"Foulkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1996,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/ijc.2910410205","article-title":"Estimates of the worldwide frequency of sixteen major cancers in 1980","volume":"41","author":"Parkin, D.M.; Laara, E.; Muir, C.S.","year":"1988","unstructured":"Parkin DM, Laara E, Muir CS. 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