{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:52:40Z","timestamp":1787161960343,"version":"build-2736575974"},"reference-count":12,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:p>As a consequence of the high consanguinity rate among the Palestinian Arabs, many recessive disorders are present with a relatively high frequency. In a survey of 2000 different Palestinian Arab families who visited our genetic clinic, in 601 an autosomal recessive disease was diagnosed or strongly suspected. The distribution of these disorders was not uniform and some disorders, such as Krabbe disease, were found at high frequency in only a small part of the population. For some other disorders, a high prevalence was also reported among Palestinian Arabs living in other regions, for example, beta thalassaemia, Bardet-Biedl syndrome, Meckel syndrome, autosomal recessive congenital hydrocephalus, and recessive osteopetrosis. In addition, as another consequence of the high consanguinity rate, two different autosomal recessive diseases were diagnosed within the same sibship in 17 of the Palestinian Arab families.<\/jats:p>","DOI":"10.1136\/jmg.34.9.765","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:37:21Z","timestamp":1226331441000},"page":"765-766","source":"Crossref","is-referenced-by-count":34,"title":["Autosomal recessive diseases among Palestinian Arabs."],"prefix":"10.1136","volume":"34","author":[{"given":"J","family":"Zlotogora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1997,9,1]]},"reference":[{"key":"ref_1","article-title":"Farag TI Genetic disorders among Arab populations. Oxford Monographs on Medical Genetics No 30","author":"Teebi, A.S.","year":"1997","unstructured":"Teebi AS, Farag TI Genetic disorders among Arab populations. Oxford Monographs on Medical Genetics No 30. Oxford: Oxford University Press, 1997."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/(SICI)1096-8628(19970211)68:4<472::AID-AJMG20>3.0.CO;2-O","volume":"68","author":"of consanguinity, Effects","year":"1997","unstructured":"Effects of consanguinity. An J Med Genet 1997;68:472-5.","journal-title":"An J Med Genet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1001\/archpedi.1994.02170040078013","article-title":"Consanguineous mating in an Israeli-Arab community","volume":"148","author":"Jaber, L.; Bailey-Wilson, J.E.; Haj-Yehia, M.; Hermandez, J.; Shohat, M.","year":"1994","unstructured":"Jaber L, Bailey-Wilson JE, Haj-Yehia M, Hermandez J, Shohat M. Consanguineous mating in an Israeli-Arab community. Arch PediatrAdolesc Med 1994;148:412-15.","journal-title":"Arch PediatrAdolesc Med"},{"key":"ref_4","first-page":"196","volume":"27","author":"Zlotogora, J.; Levy-Lahad, E.; Legum, T.C.; Zeigler, M.; Bach, G.","year":"1991","unstructured":"Zlotogora J, Levy-Lahad E, Legum TC, Zeigler M, Bach G. Krabbe disease in Israel. Isr3rMed Sci 1991;27:196-8.","journal-title":"Krabbe disease in Israel. Isr3rMed Sci"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/BF02185759","article-title":"Two different mutations are responsible for Krabbe disease in the Druze and Moslem populations in Israel","volume":"97","author":"Rafi, M.A.; Luizi, P.; Zlotogora, J.; Wenger, D.A.","year":"1996","unstructured":"Rafi MA, Luizi P, Zlotogora J, Wenger DA. Two different mutations are responsible for Krabbe disease in the Druze and Moslem populations in Israel. Hum Genet 1996;97: 304-8.","journal-title":"Hum Genet"},{"key":"ref_6","first-page":"836","article-title":"Diversity of 0-globin mutations in Israeli ethnic groups reflects recent historic events","volume":"54","author":"Filon, D.; Oron, V.; Krichevski, S.","year":"1994","unstructured":"Filon D, Oron V, Krichevski S. Diversity of 0-globin mutations in Israeli ethnic groups reflects recent historic events. AmJ Hum Genet 1994;54:836-43.","journal-title":"AmJ Hum Genet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1136\/jmg.31.3.224","article-title":"Autosomal recessive disorders among Arabs: an overview from Kuwait","volume":"31","author":"Teebi, A.S.","year":"1994","unstructured":"Teebi AS.Autosomal recessive disorders among Arabs: an overview from Kuwait. Jf Med Genet 1994;31:224-33.","journal-title":"Jf Med Genet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/hmg\/4.1.9","article-title":"Use of a DNA pooling strategy to identify a human obesity syndrome locus on chromosome","volume":"4","author":"Carmi, R.; Rockhlina, T.; Kwiteck-Black, A.E.","year":"1995","unstructured":"Carmi R, Rockhlina T, Kwiteck-Black AE, et al. Use of a DNA pooling strategy to identify a human obesity syndrome locus on chromosome 15. Hum Mol Genet 1995; 4:9-13.","journal-title":"15. Hum Mol Genet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/ajmg.1320410414","article-title":"Problems in diagnosis and delineation of inherited disorders in highly inbred populations","volume":"41","author":"Zlotogora, J.","year":"1991","unstructured":"Zlotogora J. Problems in diagnosis and delineation of inherited disorders in highly inbred populations. Am 7 Med Genet 1991;41:451-3.","journal-title":"Am 7 Med Genet"},{"key":"ref_10","first-page":"831","article-title":"The association of cystic fibrosis with homocystinuria in two Saudi siblings","volume":"155","author":"Isamil, E.A.R.; Al-Saleh, Q.A.; Zaki, M.; Rao, A.; Sombati, S.; Moosa, A.","year":"1996","unstructured":"Isamil EAR, Al-Saleh QA, Zaki M, Rao A, Sombati S, Moosa A. The association of cystic fibrosis with homocystinuria in two Saudi siblings. Eur3JPediatr 1996;155:831."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/(SICI)1096-8628(19970211)68:4<412::AID-AJMG8>3.0.CO;2-N","volume":"68","author":"Dominance, Zlotogora J.; homozygosity","year":"1997","unstructured":"Zlotogora J. Dominance and homozygosity. Am J Med Genet 1997;68:412-16.","journal-title":"Am J Med Genet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajmg.1320440102","article-title":"Marked parental consanguinity as malformations in an Israeli a cause of increased Arab community","volume":"44","author":"Jaber, L.; Merlob, P.; Bu, X.; Rotter, J.I.; Shohat, M.","year":"1992","unstructured":"Jaber L, Merlob P, Bu X, Rotter JI, Shohat M. Marked parental consanguinity as malformations in an Israeli a cause of increased Arab community. Am major J Med Genet 1992;44: 1-6.","journal-title":"Am major J Med Genet"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.34.9.765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T18:37:17Z","timestamp":1759689437000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.34.9.765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9]]},"references-count":12,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1997,9,1]]},"published-print":{"date-parts":[[1997,9]]}},"alternative-id":["10.1136\/jmg.34.9.765"],"URL":"https:\/\/doi.org\/10.1136\/jmg.34.9.765","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"value":"0022-2593","type":"print"},{"value":"1468-6244","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,9]]}}}