{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T22:40:03Z","timestamp":1760740803286,"version":"build-2065373602"},"reference-count":34,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1998,7]]},"abstract":"<jats:p>The association of choroid plexus cysts with fetal aneuploidy, particularly trisomy 18, was first noted in 1986. Through the years there have been numerous reports on this subject, but no consensus has been reached with regard to chromosomal risk. In this review, we attempt to summarise published reports on second trimester choroid plexus cysts, with an emphasis on the strengths and weaknesses of each report. Based on these reports, additional malformations are a significant risk factor for aneuploidy and an indication for determination of fetal karyotype. The management of isolated choroid plexus cysts remains controversial.<\/jats:p>","DOI":"10.1136\/jmg.35.7.554","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:37:21Z","timestamp":1226331441000},"page":"554-557","source":"Crossref","is-referenced-by-count":20,"title":["Choroid plexus cysts and aneuploidy."],"prefix":"10.1136","volume":"35","author":[{"given":"D","family":"Peleg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Yankowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,7,1]]},"reference":[{"issue":"151 000","key":"ref_1","volume":"595","author":"Gupta","year":"1994","unstructured":"Gupta 1994 595\/151 000 0.4"},{"issue":"11 700","key":"ref_2","volume":"100","author":"Ostlere","year":"1990","unstructured":"Ostlere 1990 100\/11 700 0.9"},{"key":"ref_3","unstructured":"Thorpe-Beeston 1990 -","article-title":"Thorpe-Beeston 1990 -"},{"article-title":"Achiron Obstet Gynecol","year":"1991","key":"ref_4","unstructured":"Achiron Obstet Gynecol 1991"},{"article-title":"Benaceraff AmJ Obstet Gynecol","year":"1990","key":"ref_5","unstructured":"Benaceraff AmJ Obstet Gynecol 1990"},{"article-title":"Fitzsimmons Obstet Gynecol","year":"1989","key":"ref_6","unstructured":"Fitzsimmons Obstet Gynecol 1989"},{"year":"1993","author":"Ultrasound Med","key":"ref_7","unstructured":"Ultrasound Med 1993"},{"key":"ref_8","first-page":"23","article-title":"Choroid plexus cysts: significance and current management practices","volume-title":"Semi, Ultrasounzd, CT and MRI","volume":"14","author":"Kennedy, K.A.; Carey, J.C.","year":"1993","unstructured":"Kennedy KA, Carey JC. 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