{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:40:12Z","timestamp":1790419212610,"version":"4.1.0"},"reference-count":40,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[2000,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To analyse the distributions of and generate growth charts for stature and occipitofrontal circumference (OFC) in neurofibromatosis 1 (NF1) patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>DESIGN<\/jats:title>\n                  <jats:p>Cross sectional database survey.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SETTING<\/jats:title>\n                  <jats:p>The National Neurofibromatosis Foundation International Database (NFDB) includes clinical information on NF1 patients from 14 participating centres in North America.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SUBJECTS<\/jats:title>\n                  <jats:p>A total of 569 white, North American, NF1 patients, 55% female and 45% male.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN OUTCOME MEASURES<\/jats:title>\n                  <jats:p>Stature and OFC measurements of NF1 patients were compared to age and sex matched population norms using z score standardisation and centile curves.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The distributions of stature and OFC are shifted and unimodal among NF1 patients; 13% of patients have short stature (\u2a7e2 standard deviations below the population mean) and 24% have macrocephaly (OFC \u2a7e2 standard deviations above the population mean).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Alterations of stature and OFC are not limited to NF1 patients with frank short stature or macrocephaly.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jmg.37.12.933","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:37:59Z","timestamp":1027751879000},"page":"933-938","source":"Crossref","is-referenced-by-count":88,"title":["Growth in North American white children with neurofibromatosis 1 (NF1)"],"prefix":"10.1136","volume":"37","author":[{"given":"J","family":"Szudek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Birch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"the National Neurofibromatosis Foun","family":"Participants","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2000,12,1]]},"reference":[{"key":"2025101711480836000_37.12.933.1","unstructured":"Crowe FW Schull WJ Neel JV (1956) A clinical pathological and genetic study of multiple neurofibromatosis. 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