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The absence of cancer genetics service provision in Wales before this study gave a window of opportunity in which this important trial could be conducted. The present paper describes how TRACE will provide crucial evidence regarding the psychosocial as well as resource implications of adding individualised genetic assessment, genetic counselling, and (where appropriate) gene testing to typical advice and surveillance from a hospital breast clinic. In addition, it is anticipated that TRACE will represent a model for future trials of service delivery in the increasing number of complex genetic disorders where evidence on the economic implications of screening and management is currently limited.<\/jats:p>","DOI":"10.1136\/jmg.37.3.192","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:38:40Z","timestamp":1027751920000},"page":"192-196","source":"Crossref","is-referenced-by-count":15,"title":["A model protocol evaluating the introduction of genetic assessment for women with a family history of breast cancer: Figure 1"],"prefix":"10.1136","volume":"37","author":[{"given":"Jonathon","family":"Gray","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Brain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Norman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy","family":"Anglim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liz","family":"France","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garry","family":"Barton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Branston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Parsons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angus","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Sampson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Newcombe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cerilan","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Mansel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Harper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2000,3,1]]},"reference":[{"key":"2025100511071784000_37.3.192.1","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1136\/bmj.309.6960.1003","article-title":"Breast cancer - epidemiology, risk factors and genetics.","volume":"309","author":"McPherson","year":"1994","journal-title":"BMJ"},{"key":"2025100511071784000_37.3.192.2","first-page":"1029","article-title":"A genetic study of human breast cancer.","volume":"48","author":"Anderson","year":"1972","journal-title":"J Natl Cancer Inst"},{"key":"2025100511071784000_37.3.192.3","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1136\/bmj.313.7057.572","article-title":"Testing for the breast cancer predisposition gene BRCA1.","volume":"313","author":"Eeles","year":"1996","journal-title":"BMJ"},{"key":"2025100511071784000_37.3.192.4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03500150087033"},{"key":"2025100511071784000_37.3.192.5","doi-asserted-by":"publisher","DOI":"10.1126\/science.2270482"},{"key":"2025100511071784000_37.3.192.6","doi-asserted-by":"publisher","DOI":"10.1126\/science.7545954"},{"key":"2025100511071784000_37.3.192.7","first-page":"678","article-title":"Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families.","volume":"52","author":"Easton","year":"1993","journal-title":"Am J Hum Genet"},{"key":"2025100511071784000_37.3.192.8","doi-asserted-by":"publisher","DOI":"10.1126\/science.8091231"},{"key":"2025100511071784000_37.3.192.9","doi-asserted-by":"publisher","DOI":"10.1038\/ng1095-198"},{"key":"2025100511071784000_37.3.192.10","unstructured":"Calman Hine Report (1995) A policy framework for commissioning cancer services. 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