{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:52:09Z","timestamp":1776271929634,"version":"3.50.1"},"reference-count":16,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[2000,9,1]]},"abstract":"<jats:p>The role of major gene and multifactorial inheritance in the aetiology of club foot in the New Zealand Polynesian population was studied using 287 New Zealand Maori and Pacific club foot families. The club foot family data were analysed by complex segregation analysis under the mixed model using the computer program POINTER. This analysis shows that the best genetic model for club foot in this population is a single dominant gene with a penetrance of 33% and a predicted gene frequency of 0.9%. These data provide a scientific foundation for molecular studies in the Maori and Polynesian population to identify putative club foot genes.<\/jats:p>","DOI":"10.1136\/jmg.37.9.680","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:38:40Z","timestamp":1027751920000},"page":"680-683","source":"Crossref","is-referenced-by-count":53,"title":["Genetics of club foot in Maori and Pacific people"],"prefix":"10.1136","volume":"37","author":[{"given":"Cyril","family":"Chapman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N Susan","family":"Stott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramari Viola","family":"Port","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard O","family":"Nicol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2000,9,1]]},"reference":[{"key":"2025101800052566000_37.9.680.1","unstructured":"Sullivan JA (1996) The child's foot. Lovell and Winter's pediatric orthopedics. (Lippincott-Raven, Philadelphia), 4th ed.."},{"key":"2025101800052566000_37.9.680.2","first-page":"1051","article-title":"A single-gene explanation for the probability of having idiopathic talipes equinovarus.","volume":"53","author":"Rebbeck","year":"1993","journal-title":"Am J Hum Genet"},{"key":"2025101800052566000_37.9.680.3","unstructured":"Port RV (1995) He mate huhua: he tirohanga Maori. Maori attitudes to disability: clubfoot. Thesis (University of Auckland)."},{"key":"2025101800052566000_37.9.680.4","first-page":"144","article-title":"Club foot in Maori: a genetic study of 50 kindreds.","volume":"88","author":"Beals","year":"1978","journal-title":"NZ Med J"},{"key":"2025101800052566000_37.9.680.5","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1097\/01241398-198811000-00013","article-title":"Use of the Cincinnati incision in congenital talipes equinovarus.","volume":"8","author":"Brougham","year":"1988","journal-title":"J Pediatr Orthop"},{"key":"2025101800052566000_37.9.680.6","unstructured":"Veale AMO Tapsell PW Tyler KR (1967) Clubfoot in Maoris. in Proceedings of the Third International Congress of Human Genetics, 5-10 September 1966. eds Crow JF Neel JV (Johns Hopkins University Press, Baltimore), p 102."},{"key":"2025101800052566000_37.9.680.7","doi-asserted-by":"publisher","DOI":"10.1159\/000064571"},{"key":"2025101800052566000_37.9.680.8","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.21.4.290"},{"key":"2025101800052566000_37.9.680.9","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0140-6736(85)91400-X","article-title":"On the pathogenesis of clubfoot.","volume":"16","author":"Dietz","year":"1985","journal-title":"Lancet"},{"key":"2025101800052566000_37.9.680.10","first-page":"772","article-title":"The role of major gene in clubfoot.","volume":"42","author":"Wang","year":"1988","journal-title":"Am J Hum Genet"},{"key":"2025101800052566000_37.9.680.11","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370040408"},{"key":"2025101800052566000_37.9.680.12","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1159\/000153231","article-title":"Complex segregation analysis with pointers.","volume":"31","author":"Lalouel","year":"1981","journal-title":"Hum Hered"},{"key":"2025101800052566000_37.9.680.13","first-page":"387","article-title":"A resolution of the ascertainment sampling problem. III. Pedigrees.","volume":"43","author":"Shute","year":"1988","journal-title":"Am J Hum Genet"},{"key":"2025101800052566000_37.9.680.14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000153255","article-title":"Estimation of demographic parameters from isolation by distance.","volume":"32","author":"Morton","year":"1982","journal-title":"Hum Hered"},{"key":"2025101800052566000_37.9.680.15","first-page":"515","article-title":"Clubfoot in the Polynesian: an epidemiology survey.","volume":"96","author":"Cartlidge","year":"1983","journal-title":"NZ Med J"},{"key":"2025101800052566000_37.9.680.16","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980901)79:2<97::AID-AJMG4>3.0.CO;2-K"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.37.9.680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:05:32Z","timestamp":1760771132000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.37.9.680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9,1]]},"references-count":16,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2000,9,1]]},"published-print":{"date-parts":[[2000,9,1]]}},"alternative-id":["10.1136\/jmg.37.9.680"],"URL":"https:\/\/doi.org\/10.1136\/jmg.37.9.680","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"value":"0022-2593","type":"print"},{"value":"1468-6244","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9,1]]}}}