{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:38:26Z","timestamp":1772782706211,"version":"3.50.1"},"reference-count":18,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[2000,9,1]]},"abstract":"<jats:p>A recent study suggested that the insertion (I) allele in intron 16 of the angiotensin converting enzyme gene (<jats:italic>ACE)<\/jats:italic> is associated with Alzheimer's disease (AD) risk. In our series of 239 necropsy confirmed late onset AD cases and 342 elderly non-demented controls aged &gt;73 years, we found significantly different <jats:italic>ACE<\/jats:italic> genotype distributions in the case and control groups (p=0.007). Homozygotes for both the I and D alleles were associated with a higher risk compared to DI heterozygotes. While the <jats:italic>\n                     <jats:sc>APO<\/jats:sc>E<\/jats:italic>\u03b54 allele was strongly associated with AD risk in our series, we found no evidence for an interaction between the<jats:italic>\n                     <jats:sc>APO<\/jats:sc>E<\/jats:italic> and<jats:italic>ACE<\/jats:italic> loci. In addition, no interactions were observed between <jats:italic>ACE<\/jats:italic> and gender or age at death of the AD cases. A meta-analysis of all published reports (12 case-control series in total) suggested that both the II and ID<jats:italic>ACE<\/jats:italic> genotypes are associated with increased AD risk (odds ratio (OR) for II <jats:italic>v<\/jats:italic> DD 1.36, 95% confidence interval (CI)=1.13-1.63, OR for DI<jats:italic>v<\/jats:italic> DD 1.33, 95% CI=1.14-1.53, p<jats:italic>=<\/jats:italic>0.0002).<\/jats:p>","DOI":"10.1136\/jmg.37.9.695","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:38:40Z","timestamp":1027751920000},"page":"695-697","source":"Crossref","is-referenced-by-count":85,"title":["The <i>ACE<\/i> gene and Alzheimer's disease 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