{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:57:50Z","timestamp":1792605470232,"version":"4.5.0"},"reference-count":37,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[2001,8,1]]},"DOI":"10.1136\/jmg.38.8.551","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:34:46Z","timestamp":1027751686000},"page":"551-556","source":"Crossref","is-referenced-by-count":39,"title":["Recessively inherited lower incisor hypodontia"],"prefix":"10.1136","volume":"38","author":[{"given":"Sinikka","family":"Pirinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Kentala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pekka","family":"Nieminen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppo","family":"Varilo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma","family":"Thesleff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirpa","family":"Arte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2001,8,1]]},"reference":[{"key":"2025101710355511000_38.8.551.1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0896-417"},{"key":"2025101710355511000_38.8.551.2","doi-asserted-by":"publisher","DOI":"10.1038\/71634"},{"key":"2025101710355511000_38.8.551.3","doi-asserted-by":"publisher","DOI":"10.1038\/74155"},{"key":"2025101710355511000_38.8.551.4","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1101\/gad.8.22.2691","article-title":"Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.","volume":"22","author":"van Genderen","year":"1994","journal-title":"Genes Dev"},{"key":"2025101710355511000_38.8.551.5","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF00210412","article-title":"Gene defect in hypodontia: exclusion of MSX1 and MSX2 as candidate genes.","volume":"96","author":"Nieminen","year":"1995","journal-title":"Hum Genet"},{"key":"2025101710355511000_38.8.551.6","doi-asserted-by":"publisher","DOI":"10.1177\/00220345960750060401"},{"key":"2025101710355511000_38.8.551.7","doi-asserted-by":"publisher","DOI":"10.1086\/301799"},{"key":"2025101710355511000_38.8.551.8","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20000619)92:5<346::AID-AJMG10>3.0.CO;2-A"},{"key":"2025101710355511000_38.8.551.9","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320530207"},{"key":"2025101710355511000_38.8.551.10","first-page":"219","article-title":"Hypodontia of permanent teeth. An orthopantomographic study.","volume":"67","author":"Haavikko","year":"1971","journal-title":"Suom Hammaslaak Toim"},{"key":"2025101710355511000_38.8.551.11","first-page":"267","article-title":"A controlled study of associated dental anomalies.","volume":"68","author":"Baccetti","year":"1998","journal-title":"Angle Orthod"},{"key":"2025101710355511000_38.8.551.12","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3109\/00016356909026309","article-title":"The inheritance pattern of missing, peg-shaped, and strongly mesio-distally reduced upper lateral incisors.","volume":"27","author":"Alvesalo","year":"1969","journal-title":"Acta Odontol Scand"},{"key":"2025101710355511000_38.8.551.13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1399-0004.1988.tb02895.x","article-title":"Dominant inheritance of tooth malpositions and their association to hypodontia.","volume":"34","author":"Svinhufvud","year":"1988","journal-title":"Clin Genet"},{"key":"2025101710355511000_38.8.551.14","doi-asserted-by":"publisher","DOI":"10.1177\/00220345960750100601"},{"key":"2025101710355511000_38.8.551.15","doi-asserted-by":"publisher","DOI":"10.1046\/j.0909-8836.1999.eos107204.x"},{"key":"2025101710355511000_38.8.551.16","first-page":"1","article-title":"Hypodontia in the permanent dentition. A clinical and genetical investigation.","volume":"7 (suppl 3)","author":"Grahnen","year":"1956","journal-title":"Odont Revy"},{"key":"2025101710355511000_38.8.551.17","unstructured":"Schalk van der Weide Y (1992) Oligodontia: a clinical, radiographic and genetic evaluation. PhD thesis (University of Utrecht, Utrecht)."},{"key":"2025101710355511000_38.8.551.18","first-page":"103","article-title":"The formation and the alveolar and clinical eruption of the permanent teeth. An orthopantomographic study.","volume":"66","author":"Haavikko","year":"1970","journal-title":"Suom Hammaslaak Toim"},{"key":"2025101710355511000_38.8.551.19","doi-asserted-by":"publisher","DOI":"10.1080\/000163500429280"},{"key":"2025101710355511000_38.8.551.20","unstructured":"Li CC (1961) Human genetics. Principles and methods. (McGraw-Hill, New York), pp 58\u00e2\u0080\u009378."},{"key":"2025101710355511000_38.8.551.21","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/ajpa.1330210413","article-title":"Congenital anomalies of teeth in Japanese children.","volume":"21","author":"Niswander","year":"1963","journal-title":"J Phys AnthropoI"},{"key":"2025101710355511000_38.8.551.22","unstructured":"Witkop CJ (1965) Genetic diseases of the oral cavity. in Oral pathology. ed Tiecke RW (McGraw-Hill, New York), pp 812\u00e2\u0080\u0093813."},{"key":"2025101710355511000_38.8.551.23","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1044\/jshd.3802.268","article-title":"Oligodontia, taurodontia and sparse hair growth - a syndrome?","volume":"38","author":"Moller","year":"1973","journal-title":"J Speech Hear Disord"},{"key":"2025101710355511000_38.8.551.24","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.14.2.137"},{"key":"2025101710355511000_38.8.551.25","first-page":"105","article-title":"Tooth and nail syndrome: genetic, clinical and dermatoglyphic findings: case report.","volume":"17","author":"Akyuz","year":"1993","journal-title":"J Clin Pediatr Dent"},{"key":"2025101710355511000_38.8.551.26","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.33.2.137"},{"key":"2025101710355511000_38.8.551.27","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980113)75:2<196::AID-AJMG15>3.0.CO;2-K"},{"key":"2025101710355511000_38.8.551.28","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(60)80214-4"},{"key":"2025101710355511000_38.8.551.29","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.1999.560211.x"},{"key":"2025101710355511000_38.8.551.30","first-page":"1","article-title":"Aplasia, supernumerary teeth and fused teeth in the primary dentition. An epidemiologic study.","volume":"79","author":"Ravn","year":"1971","journal-title":"Scand J Dent Res"},{"key":"2025101710355511000_38.8.551.31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3109\/00016358408993864","article-title":"Hypodontia, hyperodontia and double formation of primary teeth in Iceland. An epidemiological study.","volume":"42","author":"Magnusson","year":"1984","journal-title":"Acta Odontol Scand"},{"key":"2025101710355511000_38.8.551.32","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0011-8532(22)02265-0","article-title":"The distribution of anomalies of the primary anterior teeth and their effect on the permanent successors.","volume":"28","author":"Gellin","year":"1984","journal-title":"Dent Clin North Am"},{"key":"2025101710355511000_38.8.551.33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/00016358109162264","article-title":"Supernumerary and congenitally missing primary teeth in Finnish children. An epidemiological study.","volume":"39","author":"J\u00c3\u00a4rvinen","year":"1981","journal-title":"Acta Odontol Scand"},{"key":"2025101710355511000_38.8.551.34","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1046\/j.1365-263X.1997.00230.x","article-title":"Comparison of the pattern of agenesis in the primary and permanent dentitions in a population characterized by agenesis in the primary dentition.","volume":"7","author":"Daugaard-Jensen","year":"1997","journal-title":"Int J Pediatr Dent"},{"key":"2025101710355511000_38.8.551.35","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07302-9"},{"key":"2025101710355511000_38.8.551.36","first-page":"278","article-title":"X-linked anhidrotic ectodermal dysplasia with immunodefiency is caused by impaired NF-kB signaling.","volume":"27","author":"D\u00c3\u00b6ffinger","year":"2001","journal-title":"Nat Genet"},{"key":"2025101710355511000_38.8.551.37","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.10.1913"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.38.8.551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T17:36:05Z","timestamp":1760722565000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.38.8.551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8,1]]},"references-count":37,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2001,8,1]]},"published-print":{"date-parts":[[2001,8,1]]}},"alternative-id":["10.1136\/jmg.38.8.551"],"URL":"https:\/\/doi.org\/10.1136\/jmg.38.8.551","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"value":"0022-2593","type":"print"},{"value":"1468-6244","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8,1]]}}}