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Linkage of dyslexia to the vicinity of <jats:italic>DYX3<\/jats:italic> on 2p was confirmed with a non-parametric linkage (NPL) score of 2.55 and a lod score of 3.01 for a dominant model, and a novel locus on 7q32 close to the <jats:italic>SPCH1<\/jats:italic> locus was suggested with an NPL score of 2.77. The <jats:italic>SPCH1<\/jats:italic> locus has previously been linked with a severe speech and language disorder and autism, and a mutation in exon 14 of the <jats:italic>FOXP2<\/jats:italic> gene on 7q32 has been identified in one large pedigree. Because the language disorder associated with the <jats:italic>SPCH1<\/jats:italic> locus has some overlap with the language deficits observed in dyslexia, we sequenced the coding region of <jats:italic>FOXP2<\/jats:italic> as a candidate gene for our observed linkage in six dyslexic subjects. No mutations were identified. We conclude that <jats:italic>DYX3<\/jats:italic> appears to be important for dyslexia susceptibility in many Finnish families, and a suggested linkage of dyslexia to chromosome 7q32 will need verification in other data sets.<\/jats:p>","DOI":"10.1136\/jmg.40.5.340","type":"journal-article","created":{"date-parts":[[2003,5,13]],"date-time":"2003-05-13T19:54:11Z","timestamp":1052855651000},"page":"340-345","source":"Crossref","is-referenced-by-count":95,"title":["A genome scan for developmental dyslexia confirms linkage to chromosome 2p11 and suggests a new locus on 7q32"],"prefix":"10.1136","volume":"40","author":[{"given":"N","family":"Kaminen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Hannula-Jouppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kestil\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Lahermo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kaaranen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Myllyluoma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Voutilainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Lyytinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Nopola-Hemmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2003,5,1]]},"reference":[{"key":"2025101715025812000_40.5.340.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199801293380507"},{"key":"2025101715025812000_40.5.340.2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1057179"},{"key":"2025101715025812000_40.5.340.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1990.tb01561.x"},{"key":"2025101715025812000_40.5.340.4","doi-asserted-by":"publisher","DOI":"10.1038\/ng0298-168"},{"key":"2025101715025812000_40.5.340.5","doi-asserted-by":"publisher","DOI":"10.1038\/329537a0"},{"key":"2025101715025812000_40.5.340.6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03470110073036"},{"key":"2025101715025812000_40.5.340.7","doi-asserted-by":"publisher","DOI":"10.1016\/0010-0277(91)90058-C"},{"key":"2025101715025812000_40.5.340.8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.3.930"},{"key":"2025101715025812000_40.5.340.9","doi-asserted-by":"publisher","DOI":"10.1038\/35097076"},{"key":"2025101715025812000_40.5.340.10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1101\/gad.14.2.142","volume":"14","year":"2000","journal-title":"Genes Dev"},{"key":"2025101715025812000_40.5.340.11","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-002-0768-5"},{"key":"2025101715025812000_40.5.340.12","doi-asserted-by":"publisher","DOI":"10.1038\/nature01025"},{"key":"2025101715025812000_40.5.340.13","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.3.571"},{"key":"2025101715025812000_40.5.340.14","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.9.973"},{"key":"2025101715025812000_40.5.340.15","doi-asserted-by":"publisher","DOI":"10.1086\/339931"},{"key":"2025101715025812000_40.5.340.16","doi-asserted-by":"publisher","DOI":"10.1086\/338649"},{"key":"2025101715025812000_40.5.340.17","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.38.10.658"},{"key":"2025101715025812000_40.5.340.18","unstructured":"H\u00e4yrinen T, Serenius-Sirve S, Korkman M. 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