{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T17:10:04Z","timestamp":1760721004135,"version":"build-2065373602"},"reference-count":23,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1969,12]]},"DOI":"10.1136\/jmg.6.4.413","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:49:07Z","timestamp":1226328547000},"page":"413-421","source":"Crossref","is-referenced-by-count":39,"title":["A liveborn infant with complete triploidy (69,XXX)."],"prefix":"10.1136","volume":"6","author":[{"given":"L J","family":"Butler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Chantler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N E","family":"France","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C G","family":"Keith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1969,12,1]]},"reference":[{"key":"ref_1","article-title":"This variability of the developmental abnormalities in triploids coupled with the intersexuality in the males suggests some imbalance between the activity of the sex chromosome complement and the three autosome sets. This is borne by sex chromatin analysis. With some exceptions (Mittwoch and Delhanty, 1961; Mittwoch, Atkin, and Ellis, 1963), XXY triploids are chromatin negative (Boue, Boue, and Lazar, 1967) while the majority of chromatin positive nuclei in XXX triploids have only a single chromatin mass. In the present case only 2-50%O of the nuclei contained two chromatin bodies, which is a much smaller proportion than would be expected in 47, XXX females","year":"1967","unstructured":"(1963) (1964) (1967) (1967) (1967) (1967) (1967)","journal-title":"Schmid and Vischer; confirmed by autoradiography the presence of a single allocycloic (late replicating) X in their 71, XXXYY cell line"},{"key":"ref_2","article-title":"have reviewed the origins and frequency of triploidy in man referring extensively to the work of Beatty","author":"Edwards","year":"1967","unstructured":"This variability of the developmental abnormalities in triploids coupled with the intersexuality in the males suggests some imbalance between the activity of the sex chromosome complement and the three autosome sets. This is borne by sex chromatin analysis. With some exceptions (Mittwoch and Delhanty, 1961; Mittwoch, Atkin, and Ellis, 1963), XXY triploids are chromatin negative (Boue, Boue, and Lazar, 1967) while the majority of chromatin positive nuclei in XXX triploids have only a single chromatin mass. In the present case only 2-50%O of the nuclei contained two chromatin bodies, which is a much smaller proportion than would be expected in 47,XXX females. Schmid and Vischer (1967) confirmed by autoradiography the presence of a single allocycloic (late replicating) X in their 71, XXXYY cell line.","journal-title":"Austin (1960), and Carr; This does not need further elaboration here except to make the comment that the disproportionately high frequency of the 69, XXY karyotype among reported triploids"},{"key":"ref_3","article-title":"compared with 69, XXX and especially 69, XYY may not be due to differences in the frequency of diandry and digyny but to relative survival rates of the affected zygotes","author":"Boue, J.G.","year":"1967","unstructured":"Edwards et al. (1967) have reviewed the origins and frequency of triploidy in man referring extensively to the work of Beatty (1957), Austin (1960), and Carr (1965). This does not need further elaboration here except to make the comment that the disproportionately high frequency of the 69,XXY karyotype among reported triploids","journal-title":"Indeed Boue et al"},{"key":"ref_4","article-title":"Anomalies of fertilization leading to tri-","author":"Austin, C.R.","year":"1960","unstructured":"compared with 69,XXX and especially 69,XYY may not be due to differences in the frequency of diandry and digyny but to relative survival rates of the affected zygotes. Indeed Boue et al. (1967) and J. G. Boue and A. Boue (1968, personal communica-"},{"key":"ref_5","article-title":"Parthenogenesis and Polyploidy in Mammalia Development","author":"Beatty, R.A.","year":"1957","unstructured":"Austin, C. R. (1960). Anomalies of fertilization leading to tri-"},{"key":"ref_6","first-page":"70","article-title":"Triploidie chromosomique chez un nouveau-ne polymalforme","volume":"10","author":"Bernard, R.; Stahl, A.; Coignet, J.; Giraud, F.; Hartung, M.; Brusquet, Y.; Passeron, P.","year":"1967","unstructured":"Beatty, R. A. (1957). Parthenogenesis and Polyploidy in Mammalia Development. Cambridge University Press, Cambridge.","journal-title":"Ann. Gbneft"},{"key":"ref_7","first-page":"858","article-title":"Malformation syndrome in mother's serum was less than usually associated with haemolytic disease. No antibodies were man associated with triploidy (69 chromosomes)","volume":"1","author":"Book, J.A.; Santesson, B.","year":"1960","unstructured":"Bernard, R., Stahl, A., Coignet, J., Giraud, F., Hartung, M., Brusquet, Y., and Passeron, P. (1967). Triploidie chromosomique chez un nouveau-ne polymalforme. Ann. 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