{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T17:30:27Z","timestamp":1760722227648,"version":"build-2065373602"},"reference-count":52,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1970,12]]},"DOI":"10.1136\/jmg.7.4.345","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:49:07Z","timestamp":1226328547000},"page":"345-350","source":"Crossref","is-referenced-by-count":24,"title":["Comments on patients with sex chromosome aneuploidy: dermatoglyphs, parental ages, Xg a blood group."],"prefix":"10.1136","volume":"7","author":[{"given":"D S","family":"Borgaonkar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Mules","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1970,12,1]]},"reference":[{"key":"ref_1","article-title":"(Table III). The frequency of arches on the fingers appears to be 175-80 (S. E. 12-92) This report higher than in the general population (Table II)","author":"patients by Uchida","year":"1964","unstructured":"patients by Uchida et al. (1964) (Table III). The frequency of arches on the fingers appears to be 175-80 (S.E. 12-92) This report higher than in the general population (Table II)."},{"key":"ref_2","article-title":"For 25 patients the frequency of arches was 8%","volume-title":"62) Holt and Lindsten","volume":"8","author":"E, S.","year":"1964","unstructured":"(S.E. 8 62) Holt and Lindsten (1964) For 25 patients the frequency of arches was 8%"},{"key":"ref_3","first-page":"\"172","article-title":"44-0) Penrose","volume-title":"Pfeiffer and Kiera","volume":"9","author":"D, S.","year":"1967","unstructured":"-6 (S.D. 44-0) Penrose (1967) 172-83 (S.E. 9 40) Pfeiffer and Kiera (1968)"},{"key":"ref_4","first-page":"1","article-title":"This report 0-72 Boyer","year":"1961","unstructured":"-12 This report 0-72 Boyer et al. (1961) 1-4 Soltan (1968)","journal-title":"et al"},{"key":"ref_5","article-title":"This report Soltan","volume-title":"2 63 This report","year":"1968","unstructured":"This report Soltan (1968) 2 63 This report"},{"year":"1964","author":"Ferguson-Smith","key":"ref_6","unstructured":"Ferguson-Smith et al. (1964)"},{"article-title":"Soltan","year":"1968","key":"ref_7","unstructured":"-5 Soltan (1968)"},{"year":"1968","author":"Fr0land","key":"ref_8","unstructured":"Fr0land et al. (1968)"},{"key":"ref_9","article-title":"This report Froland","year":"1964","unstructured":"This report Froland et al. (1968) Ferguson-Smith et al. (1964)","journal-title":"et al. (1968) Ferguson-Smith et al"},{"year":"1968","author":"Froland","key":"ref_10","unstructured":"Froland et al. (1968)"},{"key":"ref_11","article-title":"0-85 This report 2 27 This report de la Chapelle","author":"Brown, Court","year":"1968","unstructured":"Court Brown (1968) 0-85 This report 2 27 This report de la Chapelle et al. (1964) Pfeiffer et al. (1966)","journal-title":"et al. (1964) Pfeiffer et al"},{"issue":"90","key":"ref_12","article-title":"XXY Klinefelter's syndrome. The average maternal age for 20 patients was 28-45 (S. E. 1 53) years as compared to the average paternal age of 30-32 (S. E. 1-70) for 21 patients. These are slightly lower than those reported by FergusonSmith","volume":"30","author":"E, S.","year":"1964","unstructured":",XXY Klinefelter's syndrome. The average maternal age for 20 patients was 28-45 (S.E. 1 53) years as compared to the average paternal age of 30-32 (S.E. 1-70) for 21 patients. These are slightly lower than those reported by FergusonSmith et al. (1964), Fr0land, Sanger, and Race (1968), and Soltan (1968) (Table IV). Inonlyone of our patients could we determine that the extra X chromosome was paternal in origin, and the father of this patient was 25. The average maternal age for 10 XMXMY patients was 30 90 (S.E. 2 0) and was found not to be significantly different when compared to the average for our XXY patients, but is higher than the average maternal age of 26-42 years for the U.S. population in 1960 and the average maternal age of 27-02 years for seven XMXPY cases.","journal-title":"et al; Fr0land, Sanger, and Race (1968), and Soltan"},{"key":"ref_13","article-title":"source of the extra X chromosome was detected: the ages of the fathers were 36 and 24 respectively at the time of the patients' births. The average maternal age for 24 cases is 27-63 (S. E. 1-59) years and the average paternal age for 23 cases is 32-57 (S. E. 2 22) years (Table IV). It may be that there is a trend towards higher paternal age, but many more cases need to be studied","author":"males. In 2 patients (de la Chapelle, XXYY","year":"1970","unstructured":",XXYY males. In 2 patients (de la Chapelle et al., 1964; Pfeiffer et al., 1966), the source of the extra X chromosome was detected: the ages of the fathers were 36 and 24 respectively at the time of the patients' births. The average maternal age for 24 cases is 27-63 (S.E. 1-59) years and the average paternal age for 23 cases is 32-57 (S.E. 2 22) years (Table IV). It may be that there is a trend towards higher paternal age, but many more cases need to be studied (Borgaonkar, Mules, and Char, 1970)."},{"key":"ref_14","article-title":"As the non-disjunction in this case probably takes place at the second meiotic division in the spermatogenesis of the father, it seemed worth while to see what the paternal age is at birth of XYY males. If, on comparison with the average for the general population differences were to be found, this would indicate whether there was any relation between paternal age and non-disjunction of the Y chromosome in the second meiotic division. Average paternal age appears to be higher with sporadic cases of single gene disorders with a dominant mode of inheritance (Murdoch","author":"males, X.Y.Y.","year":"1970","unstructured":",XYY males. As the non-disjunction in this case probably takes place at the second meiotic division in the spermatogenesis of the father, it seemed worth while to see what the paternal age is at birth of XYY males. If, on comparison with the average for the general population differences were to be found, this would indicate whether there was any relation between paternal age and non-disjunction of the Y chromosome in the second meiotic division. Average paternal age appears to be higher with sporadic cases of single gene disorders with a dominant mode of inheritance (Murdoch et al., 1970). The average age of 72 fathers of XYY males is 31-08 years (S.E. 0-85) (Table IV). A histogram (Fig.) has been prepared which shows the age dis-","journal-title":"et al; The average age of 72 fathers of XYY males is 31-08 years (S. E. 0-85) (Table IV). A histogram (Fig.) has been prepared which shows the age dis"},{"key":"ref_15","article-title":"tribution of the 89 fathers in whose spermatogenesis an error had occurred. We have included the","volume-title":"XYY cases; cases of XMO, 2 cases of XMXPYY, and 7 cases of XMXPY, and the distribution here does appear to be slightly slanted towards an increased paternal age, though not significantly different. The over-all average is 31-02 (S. E. 0 76) years and is a year more than the average of 29-89 for the U. S. population in 1960","volume":"8","unstructured":"tribution of the 89 fathers in whose spermatogenesis an error had occurred. We have included the 72 XYY cases, 8 cases of XMO, 2 cases of XMXPYY, and 7 cases of XMXPY, and the distribution here does appear to be slightly slanted towards an increased paternal age, though not significantly different. The over-all average is 31-02 (S.E. 0 76) years and is a year more than the average of 29-89 for the U.S. population in 1960."},{"key":"ref_16","article-title":"obtained a mean PR interval of 0-169","volume-title":"Average PR interval on our 6 XXY cases was 0-154 sec., and the range was 0-13 to 0-18, and 3 other patients were reported to have normal electrocardiograms (Appendix). We do not consider these as variations from the normal. Further, Price examined the electrocardiograms of 20 males with 47, XYY chromosome complement, and found that they had prolonged PR intervals of 0-184 (S. E. 0 035) sec. Our 4 patients had a mean PR interval of 0-177 sec","author":"Price, Electrocardiogram","year":"1968","unstructured":"Electrocardiogram. Price (1968) obtained a mean PR interval of 0-169 (S.E. 0-013) sec. for 13 XXY males. Average PR interval on our 6 XXY cases was 0-154 sec., and the range was 0-13 to 0-18, and 3 other patients were reported to have normal electrocardiograms (Appendix). We do not consider these as variations from the normal. Further, Price examined the electrocardiograms of 20 males with 47,XYY chromosome complement, and found that they had prolonged PR intervals of 0-184 (S.E. 0 035) sec. Our 4 patients had a mean PR interval of 0-177 sec. (Borgaonkar et al., 1968b)."},{"key":"ref_17","first-page":"473","article-title":"Is hyperploidy of sex chromosomes associated with reduced total finger ridge count?","volume":"17","author":"Alter, M.","year":"1965","unstructured":"Alter, M. (1965). Is hyperploidy of sex chromosomes associated with reduced total finger ridge count? American journal of Human Genetics, 17, 473-475.","journal-title":"American journal of Human Genetics"},{"key":"ref_18","first-page":"507","article-title":"Dermatoglyphics in XXYY Klinefelter's syndrome","volume":"18","author":"Alter, M.; Gorlin, R.; Yunis, J.; Peagler, F.; Bruhl, H.","year":"1966","unstructured":"Alter, M., Gorlin, R., Yunis, J., Peagler, F., and Bruhl, H. (1966). Dermatoglyphics in XXYY Klinefelter's syndrome. American journal of Human Genetics, 18, 507-513.","journal-title":"American journal of Human Genetics"},{"key":"ref_19","first-page":"296","article-title":"Evaluation of dermal patterns in Down's syndrome by predictive discrimination","volume":"16","author":"Borgaonkar, D.S.; Davis, M.; Herr, H.M.; Bolling, D.R.","year":"1968","unstructured":"Borgaonkar, D. S., Davis, M., Herr, H. M., and Bolling, D. R. (1968a). Evaluation of dermal patterns in Down's syndrome by predictive discrimination. Clinical Research, 16, 296.","journal-title":"Clinical Research"},{"issue":"5","key":"ref_20","first-page":"138","article-title":"The triple-X syndrome","volume":"5","author":"Borgaonkar, D.S.; Davis, M.; Herr, H.M.; Bolling, D.R.; Leger, H.","year":"1969","unstructured":"Borgaonkar, D. S., Davis, M., Herr, H. M., and Bolling, D. R. and Leger, H. (1969). The triple-X syndrome. In the First Conference on the Clinical Delineation of Birth Defects, part V. Phenotypic aspects of chromosomal aberrations. Birth Defects: Original Article Series, Vol. 5, No. 5, pp. 138-139., Mules E., and Char, F. (1970). Do the 48,XXYY males have a characteristic phenotype?-A review. Clinical Genetics. In the press.","journal-title":"the First Conference on the Clinical Delineation; Series; Phenotypic aspects of chromosomal aberrations. Birth Defects: Original Article"},{"key":"ref_21","first-page":"461","article-title":"The YY syndrome","volume":"2","author":"Borgaonkar, D.S.; Davis, M.; Herr, H.M.; Bolling, D.R.; Leger, H.; Murdoch, J.L.; McKusick, V.A.; Borkowf, S.P.; Money, J.W.; Robinson, B.W.","year":"1968","unstructured":"Borgaonkar, D. S., Davis, M., Herr, H. M., and Bolling, D. R. and Leger, H., Murdoch, J. L., McKusick, V. A., Borkowf, S. P., Money, J. W., and Robinson, B. W. (1968b). The YY syndrome. Lancet, 2, 461-462.","journal-title":"Lancet"},{"key":"ref_22","first-page":"215","article-title":"The lack of influence of parental age and birth order in the aetiology of nuclear sex chromatin-negative Turner's syndrome","volume":"25","author":"Boyer, S.H.; Ferguson-Smith, M.A.; Grumbach, M.M.","year":"1961","unstructured":"Boyer, S. H., Ferguson-Smith, M. A., and Grumbach, M. M. (1961). The lack of influence of parental age and birth order in the aetiology of nuclear sex chromatin-negative Turner's syndrome. Annals of Human Genetics, 25, 215-225.","journal-title":"Annals of Human Genetics"},{"key":"ref_23","first-page":"5","article-title":"Males with an XYY sex chromosome complement","author":"Court Brown, W.M.","year":"1968","unstructured":"Court Brown, W. M. (1968). Males with an XYY sex chromosome complement. J'ournal of Medical Genetics, 5,341-359.","journal-title":"J'ournal of Medical Genetics"},{"year":"1964","author":"de la Chapelle, A.; Hortling, H.; Sanger, R.; Race, R.R.","key":"ref_24","unstructured":"de la Chapelle, A., Hortling, H., Sanger, R., and Race, R. R. (1964)."},{"key":"ref_25","first-page":"28","article-title":"The contribution of the Xg blood groups to X chromosome aneuploidy: an interim report","volume-title":"Third International Congress of Human Genetics (Abstracts)","author":"Edwards, J.H.; Ferguson-Smith, M.A.; Fr0land, A.; Lindsten, J.; Polani, P.E.; Race, R.R.; Sanger, R.","year":"1966","unstructured":"Edwards, J. H., Ferguson-Smith, M. A., Fr0land, A., Lindsten, J., Polani, P. E., Race, R. R., and Sanger, R. (1966). The contribution of the Xg blood groups to X chromosome aneuploidy: an interim report. Third International Congress of Human Genetics (Abstracts), p. 28."},{"key":"ref_26","article-title":"Primary amentia and micro-orchidism associated","author":"Ferguson-Smith, M.A.; Johnston, A.W.; Handmaker, S.D.","year":"1960","unstructured":"Ferguson-Smith, M.A., Johnston, A. W., and Handmaker, S. D. (1960). Primary amentia and micro-orchidism associated with an"},{"key":"ref_27","first-page":"46","article-title":"Parental age and the source of the X chromosomes in XXY Klinefelter's syndrome","volume":"1","author":"Mack, W.S.; Ellis, P.M.; Dickson, M.; Sanger, R.; Race, R.R.","year":"1964","unstructured":", Mack, W. S., Ellis, P. M., Dickson, M., Sanger, R., and Race, R. R. (1964). Parental age and the source of the X chromosomes in XXY Klinefelter's syndrome. Lancet, 1, 46.","journal-title":"Lancet"},{"key":"ref_28","first-page":"145","article-title":"XXYY Klinefelter's syndrome: case report and a study of the Y chromosomes DNA replication pattern","volume":"11","author":"Ferrier, P.E.; Ferrier, S.A.","year":"1968","unstructured":"Ferrier, P. E. and Ferrier, S. A. (1968). XXYY Klinefelter's syndrome: case report and a study of the Y chromosomes DNA replication pattern. Annales de Genetique, 11, 145-151.","journal-title":"Annales de Genetique"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1056\/NEJM196406112702402","article-title":"Fingerprints and palm prints (dermatoglyphics) and palmar-flexion creases in gonadal dysgenesis, pseudohypoparathyroidism and Klinefelter's syndrome","volume":"270","author":"Forbes, A.P.","year":"1964","unstructured":"Forbes, A. P. (1964). Fingerprints and palm prints (dermatoglyphics) and palmar-flexion creases in gonadal dysgenesis, pseudohypoparathyroidism and Klinefelter's syndrome. New England Journal of Medicine, 270, 1268-1277.","journal-title":"New England Journal of Medicine"},{"key":"ref_30","article-title":"Parental origin of the sex chromosome in the","author":"Fraser, G.R.","year":"1963","unstructured":"Fraser, G. R. (1963). Parental origin of the sex chromosome in the"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/jmg.5.3.161","article-title":"Xg blood groups of 78 patients with Klinefelter's syndrome and of some of their parents","volume":"5","author":"Fr0land, A.; Sanger, R.; Race, R.R.","year":"1968","unstructured":"Fr0land, A., Sanger, R., and Race, R. R. (1968). Xg blood groups of 78 patients with Klinefelter's syndrome and of some of their parents. Journal of Medical Genetics, 5, 161-164.","journal-title":"Journal of Medical Genetics"},{"key":"ref_32","first-page":"p.","article-title":"The Genetics of Dermal Ridges","volume-title":"Charles C","author":"Holt, S.B.","year":"1968","unstructured":"Holt, S. B. (1968). The Genetics of Dermal Ridges, p. 195. Charles C. Thomas, Springfield, Illinois."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1469-1809.1964.tb00463.x","article-title":"Dermatoglyphic anomalies in Turner's syndrome","volume":"28","author":"Holt, S.B.; Lindsten, J.","year":"1964","unstructured":"Holt, S. B., and Lindsten, J. (1964). Dermatoglyphic anomalies in Turner's syndrome. Annals of Human Genetics, 28, 87-100.","journal-title":"Annals of Human Genetics"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/jmg.5.2.112","article-title":"Finger and palm prints in chromatin-positive males","volume":"5","author":"Hunter, H.","year":"1968","unstructured":"Hunter, H. (1968). Finger and palm prints in chromatin-positive males. Journal of Medical Genetics, 5, 112-117.","journal-title":"Journal of Medical Genetics"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/ajpa.1330300207","article-title":"Dermatoglyphics of the XYY syndrome","volume":"30","author":"Mavalwala, J.; Parker, C.E.; Melnyk, J.","year":"1969","unstructured":"Mavalwala, J., Parker, C. E., and Melnyk, J. (1969). Dermatoglyphics of the XYY syndrome. American Journal of Physical Anthropology, 30, 209-213.","journal-title":"American Journal of Physical Anthropology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1469-1809.1970.tb01648.x","article-title":"Achondroplasia-a genetic and statistical survey","volume":"33","author":"Murdoch, J.L.Walker; A., B.; Hall, J.G.; Abbey, H.; Smith, K.K.; McKusick, V.A.","year":"1970","unstructured":"Murdoch, J. L. Walker, B. A., Hall, J. G., Abbey, H., Smith, K. K., and McKusick, V. A. (1970). Achondroplasia-a genetic and statistical survey. Annals of Human Genetics, 33, 227-244.","journal-title":"Annals of Human Genetics"},{"key":"ref_37","series-title":"human genetics. In Proceedings of the Third International Congress of Human Genetics","first-page":"13","article-title":"Presidential address-The influence of the English tradition","author":"Penrose, L.S.","year":"1966","unstructured":"Penrose, L. S. (1966). Presidential address-The influence of the English tradition in human genetics. In Proceedings of the Third International Congress of Human Genetics, p. 13-25. Ed. by J. F."},{"key":"ref_38","first-page":"298","article-title":"Finger-print pattem and the sex chromosome","volume":"1","unstructured":"Finger-print pattem and the sex chromosome. Lancet, 1, 298-300.","journal-title":"Lancet"},{"key":"ref_39","first-page":"2","article-title":"Medical significance of finger-prints and related phenomena","unstructured":"Medical significance of finger-prints and related phenomena. British MedicalJournal, 2,321-325.","journal-title":"British MedicalJournal"},{"key":"ref_40","first-page":"507","article-title":"Dermatoglyphen bei Turnersyndrom","volume":"17","author":"Pfeiffer, R.A.; Kiera, W.","year":"1968","unstructured":"Pfeiffer, R. A., and Kiera, W. (1968). Dermatoglyphen bei Turnersyndrom. Acta Geneticae Medicae et Gemellologiae, 17, 507-522.","journal-title":"Acta Geneticae Medicae et Gemellologiae"},{"key":"ref_41","first-page":"1427","article-title":"Paternal origin of an XXYY anomaly","volume":"1","author":"Pfeiffer, R.A.; Kiera, W.; Korver, G.; Sanger, R.; Race, R.R.","year":"1966","unstructured":"Pfeiffer, R. A., and Kiera, W., Korver, G., Sanger, R., and Race, R. R. (1966). Paternal origin of an XXYY anomaly. Lancet, 1, 1427-1428.","journal-title":"Lancet"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1469-1809.1969.tb00091.x","article-title":"Chromosome anomalies, mosaicism and dermatoglyphic asymmetry","volume":"32","author":"Polani, P.E.; Polani, N.","year":"1969","unstructured":"Polani, P. E. and Polani, N. (1969). Chromosome anomalies, mosaicism and dermatoglyphic asymmetry. Annals of Human Genetics, 32, 391-402.","journal-title":"Annals of Human Genetics"},{"key":"ref_43","article-title":"The electrocardiogram in males with extra Y","author":"Price, W.H.","year":"1968","unstructured":"Price, W. H. (1968). The electrocardiogram in males with extra Y"},{"key":"ref_44","article-title":"Blood Groups in Matn","author":"Race, R.R.; Sanger, R.","year":"1968","unstructured":"Race, R. R. and Sanger, R. (1968). Blood Groups in Matn. F. A. Davis, Philadelphia."},{"key":"ref_45","unstructured":"Xg and sex-chromosome abnormalities.","article-title":"Xg and sex-chromosome abnormalities"},{"key":"ref_46","first-page":"99","article-title":"British Medical","volume":"25","unstructured":"British Medical Bulletin, 25, 99-103.","journal-title":"Bulletin"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1136\/jmg.5.3.173","article-title":"Genetic characteristics of families of XO and XXY patients, including evidence of source of X chromosomes in 7 aneuploid patients","volume":"5","author":"Soltan, H.C.","year":"1968","unstructured":"Soltan, H. C. (1968). Genetic characteristics of families of XO and XXY patients, including evidence of source of X chromosomes in 7 aneuploid patients. Journal of Medical Genetics, 5, 173-180.","journal-title":"Journal of Medical Genetics"},{"key":"ref_48","article-title":"Dermatoglyphics associated with the XXYY chromosome complement","author":"Uchida, I.A.; Miller, J.R.; Soltan, H.C.","year":"1964","unstructured":"Uchida, I. A., Miller, J. R., and Soltan, H. C. (1964). Dermatoglyphics associated with the XXYY chromosome complement."},{"key":"ref_49","first-page":"284","volume":"16","unstructured":"American Journal of Human Genetics, 16, 284-291.","journal-title":"American Journal of Human Genetics"},{"key":"ref_50","author":"Walker, B.A.; Borgaonkar, D.S.","year":"1969","unstructured":"Walker, B. A., and Borgaonkar, D. S. (1969). Quadruple-XY","journal-title":"Quadruple-XY"},{"issue":"5","key":"ref_51","first-page":"142","article-title":"Phenotypic aspects of chromosmal aberrations","volume":"5","author":"Syndrome","unstructured":"Syndrome. In the First Conference on the Clinical Delineation of Birth Defects, part V. Phenotypic aspects of chromosmal aberrations. Birth Defects: Original Article Series, Vol, 5, No. 5, pp. 142-143.","journal-title":"the First Conference on the Clinical Delineation; Birth Defects: Original Article Series"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0031-3955(16)30666-6","article-title":"The use of dermal configurations in the diagnosis of mongolism","volume":"5","author":"Walker, N.F.","year":"1958","unstructured":"Walker, N. F. (1958). The use of dermal configurations in the diagnosis of mongolism. Pediatric Clinics of North America, 5, 531-","journal-title":"Pediatric Clinics of North America"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.7.4.345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T17:25:59Z","timestamp":1760721959000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.7.4.345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,12]]},"references-count":52,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1970,12,1]]},"published-print":{"date-parts":[[1970,12]]}},"alternative-id":["10.1136\/jmg.7.4.345"],"URL":"https:\/\/doi.org\/10.1136\/jmg.7.4.345","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"type":"print","value":"0022-2593"},{"type":"electronic","value":"1468-6244"}],"subject":[],"published":{"date-parts":[[1970,12]]}}}