{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:18:41Z","timestamp":1771006721697,"version":"3.50.1"},"reference-count":24,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Genet"],"published-print":{"date-parts":[[1971,6]]},"DOI":"10.1136\/jmg.8.2.153","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T14:49:07Z","timestamp":1226328547000},"page":"153-159","source":"Crossref","is-referenced-by-count":56,"title":["Genetic studies on hypospadias in males."],"prefix":"10.1136","volume":"8","author":[{"given":"Y C","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"P V","family":"Woolley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1971,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1210\/jcem-26-4-443","article-title":"XYY karyotype in a case of familial hypogonadism","volume":"26","author":"Balodimos, M.C.; Lisco, H.; Irwin, I.; Merill, W.; Dingman, J.F.","year":"1966","unstructured":"Balodimos, M. C., Lisco, H., Irwin, I., Merill, W., and Dingman, J. F. (1966). XYY karyotype in a case of familial hypogonadism. Journal of Clinical Endocrinology and Metabolism, 26, 443-452.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0014-4827(63)90230-1","article-title":"A simple method for short term cultures from small biopsies","volume":"30","author":"Basrur, P.K.; Basrur, V.R.; Gilman, J.P.W.","year":"1963","unstructured":"Basrur, P. K., Basrur, V. R., and Gilman, J. P. W. (1963). A simple method for short term cultures from small biopsies. Experimental Cell Research, 30, 229-232.","journal-title":"Experimental Cell Research"},{"key":"ref_3","article-title":"Urologist's Correspondence Club Letter","volume":"2","author":"Bourne, N.W.","year":"1961","unstructured":"Bourne, N. W. (1961). Urologist's Correspondence Club Letter, May 20, Cited from Campbell, M. F. (1963). Urology, Vol. 2, 2nd ed., W. B. Saunders, Philadelphia.","edition":"2nd ed","journal-title":"Urology"},{"key":"ref_4","first-page":"7","article-title":"Abnormal chromosome constitutions of various congenital syndromes during 1961-1966","volume":"9","author":"Chen, Y.C.; Smith, A.; Luthardt, F.; Nunes-Vas, C.; Woolley, P.V.","year":"1968","unstructured":"Chen, Y. C., Smith, A., Luthardt, F., Nunes-Vas, C., and Woolley, P. V. (1968). Abnormal chromosome constitutions of various congenital syndromes during 1961-1966. Mammalian Chromosome Newsletter, 9, 7-15.","journal-title":"Mammalian Chromosome Newsletter"},{"key":"ref_5","first-page":"44","article-title":"Racial and prenatal factors in major congenital malformations","volume":"20","author":"Chung, C.S.; Myrianthopoulos, N.C.","year":"1968","unstructured":"Chung, C. S. and Myrianthopoulos, N. C. (1968). Racial and prenatal factors in major congenital malformations. American J,ournal of Human Genetics, 20, 44-60.","journal-title":"American J, ournal of Human Genetics"},{"key":"ref_6","first-page":"173","article-title":"Syndrome de Klinefelter chez un nourrison hypospade. Caryotype A 46 chromosome","volume":"0","author":"Grouchy, J.de; Josso, N.; Lamy, M.; Frezal, J.; Nezelof, C.; Feintuch, G.","year":"1963","unstructured":"Grouchy, J. de, Josso, N., Lamy, M., Frezal, J., Nezelof, C., Feintuch, G. (1963). Syndrome de Klinefelter chez un nourrison hypospade. Caryotype A 46 chromosome. Annales de Pediatrie, l0, 173-177.","journal-title":"Annales de Pediatrie"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1469-1809.1965.tb00500.x","article-title":"The inheritance of liability to certain diseases, estimated from the incidence among relatives","volume":"29","author":"Falconer, D.S.","year":"1965","unstructured":"Falconer, D. S. (1965). The inheritance of liability to certain diseases, estimated from the incidence among relatives. Annals of Human Genetics, 29, 51-76.","journal-title":"Annals of Human Genetics"},{"key":"ref_8","article-title":"Birth Defects","author":"Fishbein, M.","year":"1963","unstructured":"Fishbein, M. (1963). Birth Defects, Lippincott, Philadelphia."},{"key":"ref_9","first-page":"722","article-title":"Hypospadias with 47\/XXY karyotype","volume":"1","author":"Gates, R.R.","year":"1946","unstructured":"Gates, R. R. (1946). Human Genetics, Macmillan, New York. Gray, J. (1961). Hypospadias with 47\/XXY karyotype. Lancet, 1, 722.","journal-title":"Human Genetics"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0015-0282(16)33668-8","article-title":"Nuclear sex determination in azoospermic adults and in newborns with hypospadias","volume":"11","author":"Halbrecht, I.","year":"1960","unstructured":"Halbrecht, I. (1960). Nuclear sex determination in azoospermic adults and in newborns with hypospadias. Fertility and Sterility, 11, 112-117.","journal-title":"Fertility and Sterility"},{"key":"ref_11","first-page":"479","article-title":"Deletion of short arms of chromosome 4-5 in a child with defects of midline fusion","volume":"1","author":"Hirschhorn, K.; Cooper, H.L.; Firschein, I.L.","year":"1965","unstructured":"Hirschhorn, K., Cooper, H. L., and Firschein, I. L. (1965). Deletion of short arms of chromosome 4-5 in a child with defects of midline fusion. Humangenetik, 1, 479-482.","journal-title":"Humangenetik"},{"key":"ref_12","first-page":"128","article-title":"A propos du syndrome de Klinefelter et de son diagnostic precoce prepubertaire","volume":"19","author":"Klotz, H.P.; Sors, C.","year":"1958","unstructured":"Klotz, H. P. and Sors, C. (1958). A propos du syndrome de Klinefelter et de son diagnostic precoce prepubertaire. Annales d'endocrinologie, 19, 128-133.","journal-title":"Annales d'endocrinologie"},{"issue":"1","key":"ref_13","first-page":"493","article-title":"Hypospadias and other anomalies associated with partial deletion of short arms of chromosome No","volume":"4","author":"Leao, J.C.; Neu, R.; Gardner, L.I.","year":"1966","unstructured":"Leao, J. C., Neu, R., and Gardner, L. I. (1966). Hypospadias and other anomalies associated with partial deletion of short arms of chromosome No. 4. Lancet, 1, 493-494."},{"key":"ref_14","first-page":"347","article-title":"Baiat cu hipospadias si cariotip XYY. Studii si cercetari de","volume":"15","author":"Milcu, S.-M.; Negoescu, I.; Maximilian, C.; Garoiu, M.; Augustin, M.; Iliescu, I.","year":"1964","unstructured":"Milcu, S.-M., Negoescu, I., Maximilian, C., Garoiu, M., Augustin, M., and Iliescu, I. (1964). Baiat cu hipospadias si cariotip XYY. Studii si cercetari de endocrinologie, 15, 347-349.","journal-title":"endocrinologie"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0014-4827(60)90138-5","article-title":"Chromosome preparations of leukocytes cultured from human peripheral blood","volume":"20","author":"Moorhead, P.S.; Nowell, P.C.; Mellman, W.J.; Battips, D.M.; Hungerford, D.A.","year":"1960","unstructured":"Moorhead, P. S., Nowell, P. C., Mellman, W. J., Battips, D. M., and Hungerford, D. A. (1960). Chromosome preparations of leukocytes cultured from human peripheral blood. Experiment Cell Research, 20, 613-616.","journal-title":"Experiment Cell Research"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1136\/bmj.1.5274.291","article-title":"Deletions of Y chromosome in a family with muscular dystrophy and hypospadias","volume":"1","author":"Muldal, S.; Ockey, C.H.","year":"1962","unstructured":"Muldal, S. and Ockey, C. H. (1962). Deletions of Y chromosome in a family with muscular dystrophy and hypospadias. British MedicalJ'ournal, 1. 291-294.","journal-title":"British MedicalJ'ournal"},{"key":"ref_17","article-title":"Congenital Anomalies in Infancy, Ch","author":"Norman, A.P.","year":"1963","unstructured":"Norman, A. P. (1963). Congenital Anomalies in Infancy, Ch. 6, Davis, Philadelphia."},{"key":"ref_18","first-page":"184","article-title":"Autoradiography in a boy with XXY karyotype","volume":"108","author":"Passarge, E.; Thomson, J.N.","year":"1964","unstructured":"Passarge, E. and Thomson, J. N. (1964). Autoradiography in a boy with XXY karyotype. American Journal of Diseases of Children, 108, 184-188.","journal-title":"American Journal of Diseases of Children"},{"key":"ref_19","first-page":"321","article-title":"Incidencia familiar de ciertas anomalies congenitas urinarias","volume":"17","author":"Rodriguez, 0. T","year":"1965","unstructured":"Rodriguez, 0. T. (1965). Incidencia familiar de ciertas anomalies congenitas urinarias. Revista venezolana de urologia, 17, 321.","journal-title":"Revista venezolana de urologia"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/00006534-195910000-00006","article-title":"Hypospadias: A review of 230 cases","volume":"24","author":"Ross, J.F.; Farmer, A.W.; Lindsay, W.K.","year":"1959","unstructured":"Ross, J. F., Farmer, A. W., and Lindsay, W. K. (1959). Hypospadias: A review of 230 cases. Plastic and Reconstructive Surgery and The Transplantation Bulletin, 24, 357-368.","journal-title":"Plastic and Reconstructive Surgery and The Transplantation Bulletin"},{"key":"ref_21","article-title":"Hypospadias with Special Reference to Etiology","author":"Sorensen, R.","year":"1953","unstructured":"Sorensen, R. (1953). Hypospadias with Special Reference to Etiology. Munksgaard, Copenhagen."},{"key":"ref_22","article-title":"Clinical Genetics","author":"Sorsby, A.","year":"1953","unstructured":"Sorsby, A. (1953). Clinical Genetics. Butterworth, London."},{"key":"ref_23","first-page":"1271","article-title":"Zur Erblichkeit der Hypospadia","volume":"83","author":"Steiner, F.","year":"1936","unstructured":"Steiner, F. (1936). Zur Erblichkeit der Hypospadia. Munchener medizinische Wochenschrift, 83, 1271.","journal-title":"Munchener medizinische Wochenschrift"},{"key":"ref_24","first-page":"341","article-title":"Le maladies humaines par aberrations chromosomiques. Revue franfais d'etudes cliniques","volume":"5","author":"Turpin, R.; Lejeune, J.","year":"1960","unstructured":"Turpin, R. and Lejeune, J. (1960). Le maladies humaines par aberrations chromosomiques. Revue franfais d'etudes cliniques et biologiques, 5, 341-347.","journal-title":"et biologiques"}],"container-title":["Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jmg.8.2.153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:09:21Z","timestamp":1760731761000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmg.bmj.com\/lookup\/doi\/10.1136\/jmg.8.2.153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,6]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1971,6,1]]},"published-print":{"date-parts":[[1971,6]]}},"alternative-id":["10.1136\/jmg.8.2.153"],"URL":"https:\/\/doi.org\/10.1136\/jmg.8.2.153","relation":{},"ISSN":["0022-2593","1468-6244"],"issn-type":[{"value":"0022-2593","type":"print"},{"value":"1468-6244","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,6]]}}}