{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:35:29Z","timestamp":1777890929724,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[1998,3,1]]},"abstract":"<jats:p\/>\n                  <jats:p>Objective Definition of upper limits for 17\u03b1-hydroxyprogesterone (17\u03b1-OHP) is important as its measurement is used in screening for congenital adrenal hyperplasia. This study aimed at investigating the cut off concentrations in relation to the day of sample collection.<\/jats:p>\n                  <jats:p>Methods 17\u03b1-OHP concentration was determined in dried filter paper blood spots taken from cord blood and by heel pricking up to the sixth day of life. A sensitive fluoroimmunoassay (DELFIA) method was used. Samples from 1091 apparently healthy full term neonates were tested. Samples were separated according to the age of sampling.<\/jats:p>\n                  <jats:p>Results The 17\u03b1-OHP (nmol\/l blood) (median and 97.5th centile) concentrations according to the age of sampling were: cord blood (n=126) 123.7, 265.6; first day 0\u20136 hours (n=30) 49.4, 80.3; 6\u201312 hours (n=57) 42.7, 79.8; 12\u201318 hours (n=58) 38.1, 62.7; 18\u201324 hours (n=67) 28.8, 49.7; second day 24\u201336 hours (n=51) 23.6, 43.3; 36\u201348 hours (n=63) 19.9, 35.4; third day (n=200) 10.6, 23.5; fourth day (n=197) 8.8, 20.8; fifth day (n=76) 6.4, 18.3; sixth day (n=166) 6.6, 19.4.<\/jats:p>\n                  <jats:p>Conclusion Cord 17\u03b1-OHP concentrations were very high as previously described, probably owing to steroid production by fetal adrenal glands. Therefore, cord blood is not useful for screening purposes. Thereafter there is a gradual decline in 17\u03b1-OHP median concentrations. A cut off value of 30 nmol\/l blood was useful in samples obtained after 48 hours of life. However, cut off values before 48 hours should be adjusted according to the sampling time.<\/jats:p>","DOI":"10.1136\/jms.5.1.24","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T12:32:20Z","timestamp":1369917140000},"page":"24-26","source":"Crossref","is-referenced-by-count":17,"title":["Congenital adrenal hyperplasia and early newborn screening: 17\u03b1-hydroxyprogesterone (17\u03b1-OHP) during the first days of life"],"prefix":"10.1177","volume":"5","author":[{"given":"L","family":"Gru\u00f1eiro de Papendieck","sequence":"first","affiliation":[{"name":"CEDIE Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os R Gutierrez, Gallo 1330, 1425 Capital Federal, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Prieto","sequence":"additional","affiliation":[{"name":"FEI Fundaci\u00f3n de Endocrinolog\u00eda Infantil, Mansilla 2771, 1425 Capital Federal, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Chiesa","sequence":"additional","affiliation":[{"name":"FEI Fundaci\u00f3n de Endocrinolog\u00eda Infantil, Mansilla 2771, 1425 Capital Federal, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Bengolea","sequence":"additional","affiliation":[{"name":"FEI Fundaci\u00f3n de Endocrinolog\u00eda Infantil, Mansilla 2771, 1425 Capital Federal, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Bergad\u00e1","sequence":"additional","affiliation":[{"name":"CEDIE Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os R Gutierrez, Gallo 1330, 1425 Capital Federal, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1998,3,1]]},"container-title":["Journal of Medical Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1136\/jms.5.1.24","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1136\/jms.5.1.24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:49:37Z","timestamp":1777614577000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1136\/jms.5.1.24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,3,1]]}},"alternative-id":["10.1136\/jms.5.1.24"],"URL":"https:\/\/doi.org\/10.1136\/jms.5.1.24","relation":{},"ISSN":["0969-1413","1475-5793"],"issn-type":[{"value":"0969-1413","type":"print"},{"value":"1475-5793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,3,1]]}}}