{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:35:30Z","timestamp":1777890930197,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[1998,3,1]]},"abstract":"<jats:p\/>\n                  <jats:p>Objectives To determine the prevalence and molecular basis of \u03b1 thalassaemia in the British South Asian population, and the implications for genetic screening for haemoglobin disorders.<\/jats:p>\n                  <jats:p>\n                    Methods 397 South Asian subjects were screened for haemoglobinopathy with measurement of full blood count, haemoglobin electrophoresis, haemoglobin A\n                    <jats:sub>2<\/jats:sub>\n                    quantification, and plasma ferritin determination. \u03b1 Globin gene mapping was successfully performed on 266 stored buffy coat samples using a Southern blot technique after hybridisation with BglII and BamHI.\n                  <\/jats:p>\n                  <jats:p>\n                    Results Of the 266 subjects in whom gene mapping was performed, 28 had a single \u03b1+ thalassaemia deletion and one was homozygous for this deletion (gene frequency 0.056). Half of the heterozygotes had normal mean cell haemoglobin (MCH) values. A further 16 subjects had probable non-deletional \u03b1\n                    <jats:sup>+<\/jats:sup>\n                    thalassaemia. None had \u03b1\n                    <jats:sup>0<\/jats:sup>\n                    thalassaemia.\n                  <\/jats:p>\n                  <jats:p>\n                    Conclusions \u03b1 Thalassaemia is by far the commonest haemoglobinopathy in British South Asian subjects, but is not a cause of serious genetic risk. Screening and counselling should focus on subjects with more marked red cell hypochromia (MCH &lt;25 pg), thus concentrating resources on subjects of different ethnic origins who may carry the \u03b1\n                    <jats:sup>0<\/jats:sup>\n                    thalassaemia gene.\n                  <\/jats:p>","DOI":"10.1136\/jms.5.1.31","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T12:32:20Z","timestamp":1369917140000},"page":"31-33","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence and molecular basis of \u03b1 thalassaemia in British South Asians"],"prefix":"10.1177","volume":"5","author":[{"given":"O W","family":"Hassall","sequence":"first","affiliation":[{"name":"Department of Haematology, Newham General Hospital, London E13 8RU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M L","family":"Tillyer","sequence":"additional","affiliation":[{"name":"Department of Haematology, Newham General Hospital, London E13 8RU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Old","sequence":"additional","affiliation":[{"name":"National Haemoglobinopathy Reference Laboratory, The Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1998,3,1]]},"container-title":["Journal of Medical Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1136\/jms.5.1.31","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1136\/jms.5.1.31","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:49:39Z","timestamp":1777614579000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1136\/jms.5.1.31"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,3,1]]}},"alternative-id":["10.1136\/jms.5.1.31"],"URL":"https:\/\/doi.org\/10.1136\/jms.5.1.31","relation":{},"ISSN":["0969-1413","1475-5793"],"issn-type":[{"value":"0969-1413","type":"print"},{"value":"1475-5793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,3,1]]}}}