{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:35:55Z","timestamp":1777890955603,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1999,3,1]],"date-time":"1999-03-01T00:00:00Z","timestamp":920246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[1999,3,1]]},"abstract":"<jats:p\/>\n                  <jats:p>Objective To evaluate universal antenatal screening for haemoglobinopathies.<\/jats:p>\n                  <jats:p>Setting District general hospital serving a London borough with 45% ethnic minorities.<\/jats:p>\n                  <jats:p>Methods Retrospective cohort study of 1444 women referred in 1688 pregnancies and 95 tertiary referrals during 101 pregnancies.<\/jats:p>\n                  <jats:p>Results Unselected women at risk for sickle cell disease booked 2.7 weeks (95% confidence interval (CI) 0.14 to 5.1) later in gestation than those at risk for \u03b2 thalassaemia were less likely to attend counselling (83% v93%, relative risk (RR) 0.89; 95% CI 0.85 to 0.94), their partners were less likely to be tested (77% v 95%, RR 0.81; 0.77 to 0.83), and they were less likely to accept prenatal diagnosis (22% v 90%, RR 0.37; 0.24 to 0.57). Over 99% of tertiary referrals attended counselling and had their partners tested. There were no significant differences in acceptance of prenatal diagnosis between those at risk of sickle cell disease and \u03b2 thalassaemia (55% v 67%). Unselected women at risk of sickle cell disease were significantly less likely to have their partner tested or to accept prenatal diagnosis than tertiary referrals, but not those at risk of \u03b2 thalassaemia. 80% of \u03b2 thalassaemia and 16% of SS births were prevented.<\/jats:p>\n                  <jats:p>Conclusions Uptake of prenatal diagnosis among unselected women at risk of \u03b2 thalassaemia is similar to that reported by tertiary centres. It is considerably lower for sickle cell disease but could increase considerably if screening occurred earlier in gestation. Acceptance of counselling is universally high, suggesting that informed choices are made, and indicating a need to measure these outcomes for cost effectiveness studies.<\/jats:p>","DOI":"10.1136\/jms.6.1.3","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T12:32:20Z","timestamp":1369917140000},"page":"3-10","source":"Crossref","is-referenced-by-count":30,"title":["Outcomes of universal antenatal screening for haemoglobinopathies"],"prefix":"10.1177","volume":"6","author":[{"given":"P.","family":"Greengross","sequence":"first","affiliation":[{"name":"Directorate of Public Health and Health Policy, Brent & Harrow Health Authority"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hickman","sequence":"additional","affiliation":[{"name":"Social Science and Medicine Department, Imperial College School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gill","sequence":"additional","affiliation":[{"name":"Directorate of Public Health and Health Policy, Brent & Harrow Health Authority"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Dugan","sequence":"additional","affiliation":[{"name":"Brent Sickle Cell & Thalassaemia Centre, Central Middlesex Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.C.","family":"Davies","sequence":"additional","affiliation":[{"name":"Brent Sickle Cell & Thalassaemia Centre, Central Middlesex Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1999,3,1]]},"container-title":["Journal of Medical Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1136\/jms.6.1.3","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1136\/jms.6.1.3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:50:20Z","timestamp":1777614620000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1136\/jms.6.1.3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,3,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,3,1]]}},"alternative-id":["10.1136\/jms.6.1.3"],"URL":"https:\/\/doi.org\/10.1136\/jms.6.1.3","relation":{},"ISSN":["0969-1413","1475-5793"],"issn-type":[{"value":"0969-1413","type":"print"},{"value":"1475-5793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,3,1]]}}}