{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T00:35:25Z","timestamp":1793666125434,"version":"4.5.1"},"reference-count":20,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2022,8,6]]},"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The Contour Neurovascular System is a novel device designed to treat intracranial aneurysms by intrasaccular flow disruption. We report our experience and mid-term follow-up in a series of patients treated with the Contour.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The patients were divided into an intention to treat and a per protocol population, the latter defined by the successful implantation of the Contour device. The intention to treat population included 53 patients (30 women, mean age 56 years) with 60 unruptured intracranial aneurysms (53 in the anterior circulation and seven in the posterior circulation). There was clinical and angiographic follow-up immediate postoperatively and at 24 hours, 3\u2009months and 1\u2009year using the Raymond\u2013Roy classification and the O\u2019Kelly\u2013Marotta grading scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Contour was successfully implanted in 54\/60 (90%) aneurysms. With regard to the angiographic follow-up, there was adequate occlusion (defined as complete occlusion or presence of a neck remnant) in 31.5% of 54 aneurysms immediately postoperatively, 62.3% (in 53\/54 aneurysms) at 24 hours, 81.4% (in 43\/54 aneurysms) at 3\u2009months, and 89.3% (in 28\/54 aneurysms) at 1\u2009year. Technical complications in 60 aneurysms of the intention to treat population included two (3.3%) inadvertent detachments of the device. Thromboembolic events were observed in four of the 60 aneurysms (6.7%), with no clinical symptoms in three patients and transient morbidity in one (1.7%). No aneurysm bleeding was observed and no patient was retreated during the 1-year follow-up period. There was no permanent morbidity or mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Contour device is effective and safe in the treatment of intracranial aneurysms. However, more experience and long-term follow-up are needed.<\/jats:p><\/jats:sec>","DOI":"10.1136\/jnis-2022-019271","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T17:20:36Z","timestamp":1661188836000},"page":"838-843","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Endosaccular flow disruption with the Contour Neurovascular System: angiographic and clinical results in a single-center study of 60 unruptured intracranial aneurysms"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3185-0740","authenticated-orcid":false,"given":"Alessandra","family":"Biondi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Primikiris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Vitale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4425-3849","authenticated-orcid":false,"given":"Guillaume","family":"Charbonnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,8,22]]},"reference":[{"key":"2024052220010139000_15.9.838.1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2403"},{"key":"2024052220010139000_15.9.838.2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2019-015182"},{"key":"2024052220010139000_15.9.838.3","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.678151"},{"key":"2024052220010139000_15.9.838.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2016.02.001"},{"key":"2024052220010139000_15.9.838.5","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-013767"},{"key":"2024052220010139000_15.9.838.6","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000001106"},{"key":"2024052220010139000_15.9.838.7","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-014623"},{"key":"2024052220010139000_15.9.838.8","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2019-015628"},{"key":"2024052220010139000_15.9.838.9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00062-020-00876-4","article-title":"The Contour: early human experience of a novel aneurysm occlusion device","volume":"31","author":"Bhogal","year":"2021","journal-title":"Clin Neuroradiol"},{"key":"2024052220010139000_15.9.838.10","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1177\/19714009211041523","article-title":"Treatment of a middle cerebral artery bifurcation aneurysm with the novel Contour Neurovascular System compatible with 0.021\u2033 catheters","volume":"35","author":"Thormann","year":"2022","journal-title":"Neuroradiol J"},{"key":"2024052220010139000_15.9.838.11","doi-asserted-by":"crossref","DOI":"10.1227\/NEU.0000000000001783","article-title":"The safety and effectiveness of the Contour Neurovascular System (Contour) for the treatment of bifurcation aneurysms: the CERUS study","volume":"90","author":"Liebig","year":"2022","journal-title":"Neurosurgery"},{"key":"2024052220010139000_15.9.838.12","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2021-248065","article-title":"Treatment of a ruptured fetal-type posterior communicating aneurysm with a combined approach using the new Contour Neurovascular System","volume":"15","author":"Cavasin","year":"2022","journal-title":"BMJ Case Rep"},{"key":"2024052220010139000_15.9.838.13","article-title":"Contour-assisted coiling with jailed microcatheter may result in better occlusion (CoCoJaMBO) in wide-necked intracranial aneurysms: proof of principle and immediate angiographic results","author":"Wodarg","year":"2022","journal-title":"Interv Neuroradiol"},{"key":"2024052220010139000_15.9.838.14","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.3171\/2015.2.JNS142634","article-title":"Safety and efficacy of aneurysm treatment with WEB: results of the WEBCAST study","volume":"124","author":"Pierot","year":"2016","journal-title":"J Neurosurg"},{"key":"2024052220010139000_15.9.838.15","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5178"},{"key":"2024052220010139000_15.9.838.16","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4578"},{"key":"2024052220010139000_15.9.838.17","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2016-012841"},{"key":"2024052220010139000_15.9.838.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.10.113"},{"key":"2024052220010139000_15.9.838.19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neurad.2016.12.011","article-title":"Should indications for WEB aneurysm treatment be enlarged? Report of a series of 20\u00a0patients with aneurysms in \"atypical\" locations for WEB treatment","volume":"44","author":"Pierot","year":"2017","journal-title":"J Neuroradiol"},{"key":"2024052220010139000_15.9.838.20","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1161\/STROKEAHA.119.024722","article-title":"Flow diverters for intracranial aneurysms: the DIVERSION national prospective cohort study","volume":"50","author":"Gory","year":"2019","journal-title":"Stroke"}],"container-title":["Journal of NeuroInterventional Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnis-2022-019271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T03:04:48Z","timestamp":1716433488000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnis.bmj.com\/lookup\/doi\/10.1136\/jnis-2022-019271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,22]]},"references-count":20,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,8,17]]},"published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1136\/jnis-2022-019271"],"URL":"https:\/\/doi.org\/10.1136\/jnis-2022-019271","relation":{},"ISSN":["1759-8478","1759-8486"],"issn-type":[{"value":"1759-8478","type":"print"},{"value":"1759-8486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,22]]}}}