{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:43:49Z","timestamp":1790840629323,"version":"4.1.0"},"reference-count":46,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2025,10,8]]},"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Flow diverters (FDs) revolutionized cerebral aneurysm treatment by promoting aneurysm sac sealing but have limitations, including thromboembolic complications and incomplete occlusion. Rosuvastatin enhances endothelialization via endothelial progenitor cell mobilization and nitric oxide bioavailability, potentially improving FD healing. This study assessed the effect of rosuvastatin on FD endothelialization in a rabbit aneurysm model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-two rabbits with elastase-induced aneurysms underwent FD implantation in the right subclavian artery. In the same animals, FDs were placed in the descending aorta to assess side branch patency. Thirteen rabbits received rosuvastatin plus aspirin (Rosu+ASA; 10\u2009mg\/kg\/day each) and nine received aspirin alone (ASA; 10\u2009mg\/kg\/day). Two weeks post-implantation, aneurysm occlusion (O\u2019Kelly-Marotta scale), side branch patency (high frequency optical coherence tomography), and histological\/MPM strut coverage were evaluated. Rosuvastatin serum concentration was correlated with endothelial cell coverage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Complete aneurysm occlusion (OKM D) occurred in 11\/13 (84.6%) of Rosu+ASA\u2009vs 6\/9 (66.6%) of ASA animals. Patency of branches \u22651\u2009mm was higher with Rosu+ASA (17\/18 (94.4%) vs 9\/13 (46.1%), PP=0.007), as was patency of branches &lt;1\u2009mm (21\/22 (95.4%) vs 11\/15 (73.4%), P=0.036). The composite outcome (complete occlusion+patent branches) favored Rosu+ASA (10\/13 (76.9%) vs 2\/9 (22.2%), P=0.011). Histology showed a trend toward greater strut coverage and neointimal thickness in Rosu+ASA (P=0.1). Rosuvastatin serum concentration strongly correlated with endothelial cell coverage (r=0.92, P=0.02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In rabbit FD models, rosuvastatin therapy seems to improve aneurysm occlusion, preserving side branch patency. We also found an association between drug levels and endothelial cells covering the FD. These findings support further investigations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jnis-2025-024237","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:16:22Z","timestamp":1761722182000},"page":"2017-2026","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Rosuvastatin for intracranial aneurysms treated with flow diverters: preclinical study in rabbits"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3245-917X","authenticated-orcid":false,"given":"Francesco","family":"Diana","sequence":"first","affiliation":[{"name":"Interventional Neuroradiology, Vall d\u2019Hebron University Hospital, Barcelona, Spain"},{"name":"Department of Life, Health and Health Professions Sciences, Link Campus University, Rome, Italy"},{"name":"Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, Section of Neurosciences, Salerno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4797-9693","authenticated-orcid":false,"given":"G\u00e9raud","family":"Forestier","sequence":"additional","affiliation":[{"name":"Plateform EMIS, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Chauvet","sequence":"additional","affiliation":[{"name":"Plateform EMIS, CHU Limoges, Limoges, France"},{"name":"Vascular surgery, CHU Dupuytren 2, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Laure","family":"Perrin","sequence":"additional","affiliation":[{"name":"CNRS, XLIM, UMR 7252, University Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7240-220X","authenticated-orcid":false,"given":"Maxime","family":"Baudouin","sequence":"additional","affiliation":[{"name":"Radiology, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1616-9113","authenticated-orcid":false,"given":"Jonathan","family":"Cortese","sequence":"additional","affiliation":[{"name":"Plateform EMIS, CHU Limoges, Limoges, France"},{"name":"Bicetre Hospital Interventional Neuroradiology, Le Kremlin-Bicetre, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Belgacem","sequence":"additional","affiliation":[{"name":"Plateform EMIS, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Voahirana","family":"Ratsimnazafy","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Global Health - Michel Dumas, OmegaHealth; Inserm, U1094; IRD, UMR270; EpiMaCT (Epidemiology of chronic diseases in tropical zone), CHU Limoges, Department of Pharmacy, University of Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Coulomb","sequence":"additional","affiliation":[{"name":"Service de Pharmacie, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot","family":"D\u2019Arrigo","sequence":"additional","affiliation":[{"name":"Service de Pharmacie, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"Service de Pharmacie, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Dulaurent","sequence":"additional","affiliation":[{"name":"Service de Pharmacie, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Picard","sequence":"additional","affiliation":[{"name":"Service de Pharmacie, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heloise","family":"Daverat","sequence":"additional","affiliation":[{"name":"CNRS, XLIM, UMR 7252, University Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Sasselina","sequence":"additional","affiliation":[{"name":"CNRS, XLIM, UMR 7252, University Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphnee","family":"Chandellier","sequence":"additional","affiliation":[{"name":"CNRS, XLIM, UMR 7252, University Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9my","family":"Mounier","sequence":"additional","affiliation":[{"name":"Plateform EMIS, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Couquet","sequence":"additional","affiliation":[{"name":"Plateform EMIS, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Croguennec","sequence":"additional","affiliation":[{"name":"Plateform EMIS, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Micallef","sequence":"additional","affiliation":[{"name":"Plateform EMIS, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelien","family":"Le Flahec","sequence":"additional","affiliation":[{"name":"Plateform EMIS, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Dubois","sequence":"additional","affiliation":[{"name":"Plateform EMIS, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8009-8543","authenticated-orcid":false,"given":"Michele","family":"Romoli","sequence":"additional","affiliation":[{"name":"Neurology and Stroke Unit, Maurizio Bufalini Hospital, Cesena, Emilia-Romagna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charbel","family":"Mounayer","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0217-6910","authenticated-orcid":false,"given":"Sylvia M","family":"Bardet","sequence":"additional","affiliation":[{"name":"CNRS, XLIM, UMR 7252, University Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Di Salle","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, Section of Neurosciences, Salerno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faraj","family":"Terro","sequence":"additional","affiliation":[{"name":"CNRS, XLIM, UMR 7252, University Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0902-3375","authenticated-orcid":false,"given":"Aymeric","family":"Rouchaud","sequence":"additional","affiliation":[{"name":"CNRS, XLIM, UMR 7252, University Limoges, Limoges, France"},{"name":"Interventional Neuroradiology, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"2026091402151540000_18.10.2017.1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.479576"},{"key":"2026091402151540000_18.10.2017.2","doi-asserted-by":"publisher","DOI":"10.3171\/2016.8.JNS16467"},{"key":"2026091402151540000_18.10.2017.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-015-1615-4"},{"key":"2026091402151540000_18.10.2017.4","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.024722"},{"key":"2026091402151540000_18.10.2017.5","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2370"},{"key":"2026091402151540000_18.10.2017.6","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4951"},{"key":"2026091402151540000_18.10.2017.7","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyz324"},{"key":"2026091402151540000_18.10.2017.8","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31824998f9"},{"key":"2026091402151540000_18.10.2017.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2007.08.001"},{"key":"2026091402151540000_18.10.2017.10","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn081"},{"key":"2026091402151540000_18.10.2017.11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000018166.84319.55"},{"key":"2026091402151540000_18.10.2017.12","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.3171\/2015.3.JNS142841","article-title":"Rosuvastatin for enhancement of aneurysm neck endothelialization after coil embolization: promotion of endothelial progenitor cells in a rodent model","volume":"124","author":"Liu","year":"2016","journal-title":"J Neurosurg"},{"key":"2026091402151540000_18.10.2017.13","first-page":"1282","article-title":"Endothelial progenitor cells, rosuvastatin and valsartan have a comparable effect on repair of balloon-denudated carotid artery injury","volume":"11","author":"Sheu","year":"2019","journal-title":"Am J Transl Res"},{"key":"2026091402151540000_18.10.2017.14","doi-asserted-by":"publisher","DOI":"10.1177\/159101991001600204"},{"key":"2026091402151540000_18.10.2017.15","doi-asserted-by":"crossref","unstructured":"Altes TA , Cloft HJ , Short JG , et al . ARRS Executive Council Award. Creation of saccular aneurysms in the rabbit: a model suitable for testing endovascular devices. American Roentgen Ray Society. AJR Am J Roentgenol 1999;349\u201354. doi:10.2214\/ajr.174.2.1740349","DOI":"10.2214\/ajr.174.2.1740349"},{"key":"2026091402151540000_18.10.2017.16","first-page":"72","article-title":"Early thrombogenicity of coronary stents: comparison of bioresorbable polymer sirolimus-eluting and bare metal stents in an aortic rat model","volume":"10","author":"Verhaegen","year":"2020","journal-title":"Am J Cardiovasc Dis"},{"key":"2026091402151540000_18.10.2017.17","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.neurad.2020.03.005","article-title":"Multiphoton microscopy for pre-clinical evaluation of flow-diverter stents for treating aneurysms","volume":"48","author":"Bardet","year":"2021","journal-title":"J Neuroradiol"},{"key":"2026091402151540000_18.10.2017.18","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030624"},{"key":"2026091402151540000_18.10.2017.19","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2324"},{"key":"2026091402151540000_18.10.2017.20","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-011704"},{"key":"2026091402151540000_18.10.2017.21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0136405","article-title":"Statins, HMG-CoA Reductase Inhibitors, Improve Neovascularization by Increasing the Expression Density of CXCR4 in Endothelial Progenitor Cells","volume":"10","author":"Chiang","year":"2015","journal-title":"PLoS One"},{"key":"2026091402151540000_18.10.2017.22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063126","article-title":"Rosuvastatin Enhances Angiogenesis via eNOS-Dependent Mobilization of Endothelial Progenitor Cells","volume":"8","author":"Zhou","year":"2013","journal-title":"PLoS ONE"},{"key":"2026091402151540000_18.10.2017.23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.atherosclerosis.2008.11.013","article-title":"Rosuvastatin reduces atherosclerotic lesions and promotes progenitor cell mobilisation and recruitment in apolipoprotein E knockout mice","volume":"205","author":"Schroeter","year":"2009","journal-title":"Atherosclerosis"},{"key":"2026091402151540000_18.10.2017.24","first-page":"432","article-title":"Rosuvastatin protects against oxidized low\u2011density lipoprotein\u2011induced endothelial cell injury of atherosclerosis in vitro","volume":"19","author":"Geng","year":"2019","journal-title":"Mol Med Rep"},{"key":"2026091402151540000_18.10.2017.25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.biopha.2007.11.002","article-title":"Rosuvastatin prevents endothelial cell death and reduces atherosclerotic lesion formation in ApoE-deficient mice","volume":"63","author":"Enomoto","year":"2009","journal-title":"Biomed Pharmacother"},{"key":"2026091402151540000_18.10.2017.26","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.bbrc.2005.08.225","article-title":"Blockade of geranylgeranylation by rosuvastatin upregulates eNOS expression in human venous endothelial cells","volume":"PMID","author":"Landsberger","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"2026091402151540000_18.10.2017.27","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.2174\/0113816128250494231016065438","article-title":"Rosuvastatin Improves Endothelial Dysfunction in Diabetes by Normalizing Endoplasmic Reticulum Stress via Calpain-1 Inhibition","volume":"PMID","author":"Zhao","year":"2023","journal-title":"Curr Pharm Des"},{"key":"2026091402151540000_18.10.2017.28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0280741","article-title":"The effect of lipid-lowering therapies on the pro-inflammatory and anti-inflammatory properties of vascular endothelial cells","volume":"PMCID","author":"Wo\u017aniak","year":"2023","journal-title":"PLoS One"},{"key":"2026091402151540000_18.10.2017.29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01416.x"},{"key":"2026091402151540000_18.10.2017.30","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000063385.12476.A7"},{"key":"2026091402151540000_18.10.2017.31","doi-asserted-by":"publisher","DOI":"10.2174\/138161207780831220"},{"key":"2026091402151540000_18.10.2017.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2006.06.012"},{"key":"2026091402151540000_18.10.2017.33","first-page":"543","article-title":"Statins and angiogenesis: is it about connections? Biochem Biophys Res Commun","volume":"PMID","author":"Khaidakov","year":"2009","journal-title":"Epub"},{"key":"2026091402151540000_18.10.2017.34","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10020183","article-title":"Pravastatin Promotes Endothelial Colony-Forming Cell Function, Angiogenic Signaling and Protein Expression In Vitro","volume":"10","author":"Meyer","year":"2021","journal-title":"J Clin Med"},{"key":"2026091402151540000_18.10.2017.35","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5430"},{"key":"2026091402151540000_18.10.2017.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.10.008"},{"key":"2026091402151540000_18.10.2017.37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0280741","article-title":"The effect of lipid-lowering therapies on the pro-inflammatory and anti-inflammatory properties of vascular endothelial cells","volume":"18","author":"Wo\u017aniak","year":"2023","journal-title":"PLoS One"},{"key":"2026091402151540000_18.10.2017.38","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.amjcard.2019.02.019","article-title":"Comparison of Rosuvastatin Versus Atorvastatin for Coronary Plaque Stabilization","volume":"123","author":"Thondapu","year":"2019","journal-title":"Am J Cardiol"},{"key":"2026091402151540000_18.10.2017.39","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2022-019240"},{"key":"2026091402151540000_18.10.2017.40","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1227\/neu.0000000000002522","article-title":"Effect of Statin on Radiographic and Clinical Outcomes of Intracranial Aneurysms Treated With Pipeline Embolization: A Propensity Score-Matched Analysis","volume":"93","author":"Salih","year":"2023","journal-title":"Neurosurgery"},{"key":"2026091402151540000_18.10.2017.41","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3171\/2024.5.JNS24476","article-title":"Timing, type, and impact of thromboembolic events caused by flow diversion: a 10-year experience","volume":"142","author":"Ramirez-Velandia","year":"2024","journal-title":"J Neurosurg"},{"key":"2026091402151540000_18.10.2017.42","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/JS9.0000000000000762","article-title":"Flow-diverter stents in intracranial aneurysm treatment: impact on covered cerebral artery branches","volume":"110","author":"Liu","year":"2024","journal-title":"Int J Surg"},{"key":"2026091402151540000_18.10.2017.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2023.08.005"},{"key":"2026091402151540000_18.10.2017.44","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn212"},{"key":"2026091402151540000_18.10.2017.45","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.18.2051"},{"key":"2026091402151540000_18.10.2017.46","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcn089"}],"container-title":["Journal of NeuroInterventional Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnis-2025-024237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:16:34Z","timestamp":1789377394000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnis.bmj.com\/lookup\/doi\/10.1136\/jnis-2025-024237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,28]]},"references-count":46,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,9,14]]},"published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1136\/jnis-2025-024237"],"URL":"https:\/\/doi.org\/10.1136\/jnis-2025-024237","relation":{},"ISSN":["1759-8478","1759-8486"],"issn-type":[{"value":"1759-8478","type":"print"},{"value":"1759-8486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,28]]}}}