{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T18:28:19Z","timestamp":1763922499253,"version":"3.45.0"},"reference-count":20,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2025,11,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mechanical thrombectomy (MT) is a well-established treatment for acute ischemic stroke (AIS) due to large vessel occlusion (LVO). However, its role in cervical artery dissection-related (CeAD) LVO remains debated due to anatomical complexities and procedural challenges. This systematic review and meta-analysis aims to evaluate the safety, efficacy, and clinical outcomes of MT in patients with AIS due to CeAD-related LVO compared with other AIS etiologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Embase, and Scopus were systematically searched from inception to March 2025. Comparative observational studies evaluating the use of MT in adult patients with AIS due to LVO were included, specifically those comparing outcomes in patients with CeAD versus non-CeAD etiologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MT for CeAD-related AIS showed no statistically significant difference in successful recanalization compared with non-CeAD cases (OR 0.81 (95% CI 0.63 to 1.04), P=0.10). However, patients with CeAD-related AIS had significantly higher rates of 90-day functional independence (modified Rankin Scale score 0\u20132) (OR 2.17 (95% CI 1.55 to 3.05), P&lt;0.01) and lower 90-day mortality (OR 0.34 (95% CI 0.22 to 0.53), P&lt;0.01). Rates of distal embolization (OR 1.60 (95% CI 0.69 to 3.70), P=0.27), symptomatic intracranial hemorrhage (OR 0.84 (95% CI 0.51 to 1.38), P=0.49), or iatrogenic dissection (OR 1.58 (95% CI 0.59 to 4.22), P=0.36) did not differ significantly between patient groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MT in patients with CeAD-related LVO is safe, effective, and associated with improved functional outcomes and lower mortality compared with patients with non-CeAD acute ischemic causes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jnis-2025-024339","type":"journal-article","created":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T18:20:14Z","timestamp":1763922014000},"page":"jnis-2025-024339","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanical thrombectomy for cervical artery dissection-related stroke: a systematic review and meta-analysis"],"prefix":"10.1136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5711-7184","authenticated-orcid":false,"given":"Dina","family":"Ramadan","sequence":"first","affiliation":[{"name":"Department of Radiology, Alexandria University Faculty of Medicine, Alexandria, Alexandria Governorate, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2860-6496","authenticated-orcid":false,"given":"Seyed Behnam","family":"Jazayeri","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences Sina Trauma and Surgery Research Center, Tehran, Iran (the Islamic Republic of)"},{"name":"Department of Neuroscience, University of California San Diego School of Medicine, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Mirahmadi Eraghi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Islamic Azad University, Qeshm, Iran (the Islamic Republic of)"},{"name":"Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Tehran Province, Iran (the Islamic Republic of)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trey","family":"Seymour","sequence":"additional","affiliation":[{"name":"University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Kendall","sequence":"additional","affiliation":[{"name":"University of South Dakota Sanford School of Medicine, Vermillion, South Dakota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada S","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, October 6 University Faculty of Medicine, 6th of October City, Giza Governorate, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley","family":"Dennison","sequence":"additional","affiliation":[{"name":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelrahman M","family":"Hamouda","sequence":"additional","affiliation":[{"name":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Atieh","sequence":"additional","affiliation":[{"name":"School of Medicine, Royal College of Surgeons in Ireland Medical University of Bahrain, Adliya, Capital Governorate, Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Derhab","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5629-3023","authenticated-orcid":false,"given":"Sherief","family":"Ghozy","sequence":"additional","affiliation":[{"name":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA"},{"name":"Department of Radiology, Mayo Clinic Minnesota, Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6786-9953","authenticated-orcid":false,"given":"Ramanathan","family":"Kadirvel","sequence":"additional","affiliation":[{"name":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA"},{"name":"Department of Radiology, Mayo Clinic Minnesota, Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5271-5524","authenticated-orcid":false,"given":"Waleed","family":"Brinjikji","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic Minnesota, Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David F","family":"Kallmes","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic Minnesota, Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,11,23]]},"reference":[{"key":"2025112310200662000_jnis-2025-024339v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70084-5"},{"key":"2025112310200662000_jnis-2025-024339v1.2","doi-asserted-by":"crossref","DOI":"10.5812\/archneurosci.26670","article-title":"Cervical Artery Dissection: A Review of the Epidemiology, Pathophysiology, Treatment, and Outcome","volume":"2","author":"Blum","year":"2015","journal-title":"Arch Neurosci"},{"key":"2025112310200662000_jnis-2025-024339v1.3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/2396987317748545","article-title":"Endovascular 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