{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:43:17Z","timestamp":1792600997323,"version":"4.5.0"},"reference-count":17,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2026,5,25]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) delay gastric emptying and may increase aspiration risk, but their impact in patients with acute ischemic stroke patients who are undergoing endovascular thrombectomy (EVT) is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective cohort study of consecutive patients undergoing EVT for acute ischemic stroke at a tertiary care center between 1 January 2020 and 5 May 2025. GLP-1 RA use was defined as documented active therapy at hospital presentation. The primary outcome was aspiration pneumonia within 30 days of EVT. Secondary outcomes included symptomatic intracranial hemorrhage (sICH) and 90-day functional outcome (modified Rankin Scale, mRS). Propensity score matching was used to reduce covariate imbalances.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 740\u2009patients were included, of whom 41 (5.5%) were receiving GLP-1 RAs. Aspiration pneumonia occurred more frequently among GLP-1 RA users than non-users (26.8% vs 10.3%; absolute risk difference 16.5%). GLP-1 RA use was associated with higher odds of aspiration pneumonia in both unmatched (OR 3.19, 95%\u2009CI 1.54 to 6.64; p=0.001) and matched analyses (adjusted OR 3.25, 95%\u2009CI 1.43 to 7.40; p=0.008). Rates of sICH were similar (4.9% vs 9.1%; OR 0.32, 95%\u2009CI 0.04 to 2.53; p=0.28), as were 90-day functional outcomes (common OR 1.14, 95%\u2009CI 0.58 to 2.25; p=0.70) in the matched analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pre-stroke GLP-1 RA use was associated with increased aspiration pneumonia risk following EVT without differences in hemorrhagic complications or functional outcomes. These findings support targeted aspiration-prevention strategies while reinforcing that EVT should not be withheld based on GLP-1 RA exposure alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jnis-2026-025486","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T17:20:24Z","timestamp":1780680024000},"page":"jnis-2026-025486","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["GLP-1 receptor agonist use and aspiration pneumonia risk following endovascular thrombectomy"],"prefix":"10.1136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2518-5836","authenticated-orcid":false,"given":"Sahil","family":"Sardana","sequence":"first","affiliation":[{"name":"Neurology, Allegheny Health Network, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihas","family":"Mateti","sequence":"additional","affiliation":[{"name":"Neurology, Allegheny Health Network, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Todd","family":"Hackett","sequence":"additional","affiliation":[{"name":"Neurology, Allegheny Health Network, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3777-5670","authenticated-orcid":false,"given":"Romil","family":"Singh","sequence":"additional","affiliation":[{"name":"Neurology, Allegheny Health Network, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9180-7083","authenticated-orcid":false,"given":"Suhani","family":"Bagga","sequence":"additional","affiliation":[{"name":"Neurology, Allegheny Health Network, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4028-5354","authenticated-orcid":false,"given":"Dharani","family":"Kotekal","sequence":"additional","affiliation":[{"name":"Neurology, Allegheny Health Network, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6686-0787","authenticated-orcid":false,"given":"Ajna","family":"Prahalad","sequence":"additional","affiliation":[{"name":"Neurology, Allegheny Health Network, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2045-1119","authenticated-orcid":false,"given":"Hassan Abdullah","family":"Shakeel","sequence":"additional","affiliation":[{"name":"Neurology, Allegheny Health Network, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Kamboj","sequence":"additional","affiliation":[{"name":"Neurology, Allegheny Health Network, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7214-198X","authenticated-orcid":false,"given":"Muhammad","family":"Saim","sequence":"additional","affiliation":[{"name":"Neurology, Allegheny Health Network, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Luther","sequence":"additional","affiliation":[{"name":"Neurosurgery, Allegheny Health Network, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Zulfiqar","sequence":"additional","affiliation":[{"name":"Neurology, Allegheny Health Network, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Cerejo","sequence":"additional","affiliation":[{"name":"Neurology, Allegheny Health Network, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"2026060510201474000_jnis-2026-025486v1.1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e318284056a"},{"key":"2026060510201474000_jnis-2026-025486v1.2","doi-asserted-by":"crossref","DOI":"10.1186\/s12877-022-02960-5","article-title":"Prevalence of dysphagia and risk of pneumonia and mortality in acute stroke patients: a meta-analysis","volume":"22","author":"Banda","year":"2022","journal-title":"BMC Geriatr"},{"key":"2026060510201474000_jnis-2026-025486v1.3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000492730","article-title":"Impact of Dysphagia Assessment and Management on Risk of Stroke-Associated Pneumonia: A Systematic Review","volume":"46","author":"Eltringham","year":"2018","journal-title":"Cerebrovasc Dis"},{"key":"2026060510201474000_jnis-2026-025486v1.4","unstructured":"Joshi G , Abdelmalak B , Weigel W , et al . American Society of anesthesiologists consensus-based guidance on preoperative management of patients (adults and children) on glucagon-like peptide-1 (GLP-1) receptor agonists. 2023. 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