{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:18:19Z","timestamp":1761895099256},"reference-count":32,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2009,12,2]]},"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Thrombus formation during endovascular embolization of intracranial aneurysms occurs in 2.9%\u20136% of patients. Use of IIb\/IIIA inhibitors such as abciximab or eptifibatide intravenously has been reported in management of this complication. Because the intra-arterial infusion of IIb\/IIIA inhibitors may require lower doses to achieve thrombolysis, it may reduce the risk of haemorrhage. Therefore, we retrospectively analyze our database and review the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective analysis of a prospectively acquired database of patients with ruptured or unruptured aneurysm treated intra-arterially for thrombus formation during endovascular coil embolization between July 2005 and August 2008. Patient demographics, aneurysmal characteristics, procedural, clinical outcome and complications were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From July 2005 to August 2008, out of 184 patients who underwent coil embolization, 19 patients (15 smokers, 14 female, mean age 52) developed intraprocedural thrombus formation and received intra-arterial abciximab treatment. Mean aneurysm size was 6.6\u2005mm\u00b14.9\u2005mm; neck size was 3.8\u2005mm\u00b12.1\u2005mm. Eight (42.1%) aneurysms were ruptured. Most aneurysms (63.1%) were in anterior communicating and middle cerebral arteries. Thrombus was visualized in all cases by angiogram and treated intra-arterially with a mean dose of 10.5\u2005mg\u00b14.2. There were no periprocedural hemorrhagic complications. No deaths or other complications occurred during follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thrombus formation during coil embolization of intracranial aneurysms occurred more in women and smokers. Low doses of intra-arterial abciximab may be effective in the thromboembolic complications occurring during endovascular embolization of intracranial aneurysms.<\/jats:p><\/jats:sec>","DOI":"10.1136\/jnis.2009.001933","type":"journal-article","created":{"date-parts":[[2010,6,16]],"date-time":"2010-06-16T20:30:29Z","timestamp":1276720229000},"page":"135-138","source":"Crossref","is-referenced-by-count":26,"title":["Intra-arterial abciximab for the treatment of thrombus formation during coil embolization of intracranial aneurysms"],"prefix":"10.1136","volume":"2","author":[{"given":"Italo","family":"Linfante","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vahid","family":"Etezadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Andreone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"DeLeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Alehashemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Wakhloo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2010,5,27]]},"reference":[{"key":"2024052222444212000_2.2.135.1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0490"},{"key":"2024052222444212000_2.2.135.2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0757"},{"key":"2024052222444212000_2.2.135.3","first-page":"2035","article-title":"Thromboembolic events associated with Guglielmi detachable coil embolization with use of diffusion-weighted MR imaging. 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