{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T18:07:56Z","timestamp":1783793276023,"version":"3.55.0"},"reference-count":15,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2010,7,20]]},"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:sec>\n                  <jats:title>Background and aim<\/jats:title>\n                  <jats:p>When a cerebral embolism occurs, pressure gradients in the arteries between sites proximal and distal to the embolus exert hydromechanical forces that push the embolus distally, and potentially affect successful revascularization during clot removal. We investigated the relationships between blood pressures that occur immediately distal and proximal to the embolus, systemic blood pressure and clinical variables.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>36 patients with embolism of the internal carotid artery (13 patients) or the proximal middle cerebral artery (23 patients) were treated using intra-arterial thrombolysis. The mean blood pressure (MBP) at the sites proximal (proximal MBP) and distal (distal MBP) to the embolus was measured with a microcatheter. Simultaneously, the systemic MBP was recorded by cuff measurement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Proximal, distal and systemic MBPs (mean\u00b1SD) were 95.2\u00b113.2\u2005mm\u2002Hg, 35.9\u00b113.5\u2005mm\u2002Hg and 98.2\u00b112.2\u2005mm\u2002Hg, respectively. The proximal MBP was significantly higher in the patients with systemic MBP\u2265100\u2005mm\u2002Hg than those with systemic MBP&lt;100\u2005mm\u2002Hg (p&lt;0.05). The distal MBP showed no difference between the high and normal systemic MBP groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Higher systemic blood pressure produced stronger hydromechanical forces on the clot, forming a proximal\u2013distal blood pressure gradient across the clot. The stronger hydromechanical force could result in higher compaction of the clot, thus making it more difficult to remove.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jnis.2010.003061","type":"journal-article","created":{"date-parts":[[2010,12,17]],"date-time":"2010-12-17T20:53:33Z","timestamp":1292619213000},"page":"43-46","source":"Crossref","is-referenced-by-count":13,"title":["Blood pressure measurement in the artery proximal and distal to an intra-arterial embolus during thrombolytic therapy"],"prefix":"10.1136","volume":"3","author":[{"given":"Takatoshi","family":"Sorimachi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiko","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,12,16]]},"reference":[{"key":"2025092912453877000_3.1.43.1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1486"},{"key":"2025092912453877000_3.1.43.2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1604"},{"key":"2025092912453877000_3.1.43.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000260187.33864.a7"},{"key":"2025092912453877000_3.1.43.4","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.561431"},{"key":"2025092912453877000_3.1.43.5","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.497115"},{"key":"2025092912453877000_3.1.43.6","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.568451"},{"key":"2025092912453877000_3.1.43.7","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.571943"},{"key":"2025092912453877000_3.1.43.8","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000171066.25248.1d"},{"key":"2025092912453877000_3.1.43.9","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.525089"},{"key":"2025092912453877000_3.1.43.10","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.544957"},{"key":"2025092912453877000_3.1.43.11","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-007-0297-y"},{"key":"2025092912453877000_3.1.43.12","doi-asserted-by":"crossref","first-page":"870","DOI":"10.3171\/jns.2005.102.5.0870","article-title":"Blood pressure in the artery distal to an intraarterial embolus during thrombolytic therapy for occlusion of a major artery: a predictor of cerebral infarction following good recanalization","volume":"102","author":"Sorimachi","year":"2005","journal-title":"J Neurosurg"},{"key":"2025092912453877000_3.1.43.13","first-page":"1391","article-title":"Recanalization by mechanical embolus disruption during intra-arterial thrombolysis in the carotid territory","volume":"25","author":"Sorimachi","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"2025092912453877000_3.1.43.14","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0090-3019(97)00278-4","article-title":"Intra-aneurysmal pressure changes during angiography in coil embolization","volume":"48","author":"Sorimachi","year":"1997","journal-title":"Surg Neurol"},{"key":"2025092912453877000_3.1.43.15","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1161\/01.STR.19.5.604","article-title":"Interobserver agreement for the assessment of handicap in stroke patients","volume":"19","author":"Van Swieten","year":"1988","journal-title":"Stroke"}],"container-title":["Journal of NeuroInterventional Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnis.2010.003061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:45:51Z","timestamp":1759175151000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnis.bmj.com\/lookup\/doi\/10.1136\/jnis.2010.003061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,16]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,2,9]]},"published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1136\/jnis.2010.003061"],"URL":"https:\/\/doi.org\/10.1136\/jnis.2010.003061","relation":{},"ISSN":["1759-8478","1759-8486"],"issn-type":[{"value":"1759-8478","type":"print"},{"value":"1759-8486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,16]]}}}