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This prompts the concern that it might be too late to employ A\u03b2 targeting therapies once tau mediated neurodegeneration has occurred. Therefore, it is timely and very important to develop tau directed therapies. The pathomechanisms of tau mediated neurodegeneration are unclear but hyperphosphorylation, oligomerisation, fibrillisation and propagation of tau pathology have been proposed as the likely pathological processes that induce loss of function or gain of toxic function of tau, causing neurodegeneration. Here we review the strategies for tau directed treatments based on recent progress in research on tau and our understanding of the pathomechanisms of tau mediated neurodegeneration.<\/jats:p>","DOI":"10.1136\/jnnp-2012-303144","type":"journal-article","created":{"date-parts":[[2012,10,21]],"date-time":"2012-10-21T01:32:02Z","timestamp":1350783122000},"page":"784-795","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":107,"title":["Therapeutic strategies for tau mediated neurodegeneration"],"prefix":"10.1136","volume":"84","author":[{"given":"Yasumasa","family":"Yoshiyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia M Y","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Q","family":"Trojanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,10,20]]},"reference":[{"key":"2024031110301382000_84.7.784.1","unstructured":"Alzheimer's Disease International WHO. 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