{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:24:02Z","timestamp":1793229842783,"version":"4.5.0"},"reference-count":53,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Neurol Neurosurg Psychiatry"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1136\/jnnp-2012-304436","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T03:25:48Z","timestamp":1363231548000},"page":"1288-1295","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":185,"title":["Clinical utility of dopamine transporter single photon emission CT (DaT-SPECT) with (<sup>123<\/sup>I) ioflupane in diagnosis of parkinsonian syndromes"],"prefix":"10.1136","volume":"84","author":[{"given":"Nin","family":"Bajaj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Hauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor D","family":"Grachev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,3,13]]},"reference":[{"key":"key-10.1136\/jnnp-2012-304436-1","unstructured":"European Medicines Agency prescribing information for DaTSCAN Website. http:\/\/www.ema.europa.eu\/ema\/index.jsp?curl=pages\/medicines\/human\/medicines\/000266\/human_med_000739.jsp&mid=WC0b01ac058001d124 (accessed 8 Jun 2011)."},{"key":"key-10.1136\/jnnp-2012-304436-2","unstructured":"FDA prescribing information for DaTscan Website. http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2011\/022454sOrig1s000Lbl.pdf (accessed 2 Feb 2011)."},{"key":"key-10.1136\/jnnp-2012-304436-3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases","volume":"55","author":"Hughes","year":"1992","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2012-304436-4","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1212\/WNL.57.8.1497","article-title":"Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease","volume":"57","author":"Hughes","year":"2001","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2012-304436-5","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/brain\/awf080","article-title":"The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service","volume":"125","author":"Hughes","year":"2002","journal-title":"Brain"},{"key":"key-10.1136\/jnnp-2012-304436-6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/ageing\/28.2.99","article-title":"Accuracy of diagnosis in patients with presumed Parkinson's disease","volume":"28","author":"Meara","year":"1999","journal-title":"Age Ageing"},{"key":"key-10.1136\/jnnp-2012-304436-7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00002826-200001000-00007","article-title":"Pramipexole with levodopa in early Parkinson's disease: design and methods of the CALM-PD Study","volume":"23","author":"Parkinson Study Group","year":"2000","journal-title":"Clin Neuropharmacol"},{"key":"key-10.1136\/jnnp-2012-304436-8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/ana.10609","article-title":"Slower progression of Parkinson's disease with ropinirole versus levodopa: the REAL-PET Study","volume":"54","author":"Whone","year":"2003","journal-title":"Ann Neurol"},{"issue":"Suppl 4","key":"key-10.1136\/jnnp-2012-304436-9","first-page":"iv37","article-title":"Does levodopa slow or hasten the rate of progression of Parkinson's disease?","volume":"252","author":"Fahn S and Parkinson Study Group","year":"2005","journal-title":"J Neurol"},{"issue":"Suppl 1","key":"key-10.1136\/jnnp-2012-304436-10","first-page":"A274","article-title":"Long-term follow-up of patients with scans without evidence of dopaminergic deficit (SWEDD) in the ELLDOPA study","volume":"64","author":"Marek","year":"2005","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2012-304436-11","first-page":"353","article-title":"The role of neuroimaging in the early diagnosis and evaluation of Parkinson's disease","volume":"96","author":"Seibyl","year":"2005","journal-title":"Minerva Medica"},{"key":"key-10.1136\/jnnp-2012-304436-12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1552-6569.2011.00583.x","article-title":"[123I]FP-CIT (DaTscan) SPECT Brain Imaging in Patients with Suspected Parkinsonian Syndromes","volume":"22","author":"Hauser","year":"2012","journal-title":"J Neuroimaging"},{"key":"key-10.1136\/jnnp-2012-304436-13","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1136\/jnnp.73.5.529","article-title":"How valid is the clinical diagnosis of Parkinson's disease in the community?","volume":"73","author":"Schrag","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2012-304436-14","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1002\/mds.22359","article-title":"Accuracy of Parkinson's disease diagnosis in 610 general practice patients in the West of Scotland","volume":"24","author":"Newman","year":"2009","journal-title":"Mov Disord"},{"key":"key-10.1136\/jnnp-2012-304436-15","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1136\/jnnp.2009.193391","article-title":"Accuracy of clinical diagnosis in tremulous parkinsonian patients: a blinded video study","volume":"81","author":"Bajaj","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2012-304436-16","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1002\/mds.22216","article-title":"Arm swing is reduced in idiopathic cervical dystonia","volume":"23","author":"K\u00e4gi","year":"2008","journal-title":"Mov Disord"},{"key":"key-10.1136\/jnnp-2012-304436-17","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1002\/mds.21685","article-title":"Patients with adult-onset dystonic tremor resembling parkinsonian tremor have scans without evidence of dopaminergic deficit (SWEDDs)","volume":"22","author":"Schneider","year":"2007","journal-title":"Mov Disord"},{"key":"key-10.1136\/jnnp-2012-304436-18","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/mds.22108","article-title":"Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: a 3-year European multicenter study with repeat [123I]-FP-CIT SPECT","volume":"24","author":"Marshall","year":"2009","journal-title":"Mov Disord"},{"key":"key-10.1136\/jnnp-2012-304436-19","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0166-2236(99)01447-2","article-title":"The dopamine hypothesis of reward: past and current status","volume":"22","author":"Spanagel","year":"1999","journal-title":"Trends Neurosci"},{"key":"key-10.1136\/jnnp-2012-304436-20","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2165\/00002512-200016040-00003","article-title":"Tremor-predominant Parkinson's disease. Approaches to treatment","volume":"16","author":"Marjama-Lyons","year":"2000","journal-title":"Drugs Aging"},{"key":"key-10.1136\/jnnp-2012-304436-21","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1002\/mds.22343","article-title":"Levodopa response in early Parkinson's disease","volume":"24","author":"Hauser","year":"2009","journal-title":"Mov Disord"},{"key":"key-10.1136\/jnnp-2012-304436-22","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/mds.21894","article-title":"Placebo response in Parkinson's disease: comparisons among 11 trials covering medical and surgical interventions","volume":"23","author":"Goetz","year":"2008","journal-title":"Mov Disord"},{"key":"key-10.1136\/jnnp-2012-304436-23","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1212\/WNL.39.12.1587","article-title":"Acute and chronic effects of propranolol and primidone in essential tremor","volume":"39","author":"Koller","year":"1989","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2012-304436-24","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1001\/archneur.1987.00520210023013","article-title":"Adjuvant therapy of parkinsonian tremor","volume":"44","author":"Koller","year":"1987","journal-title":"Arch Neurol"},{"key":"key-10.1136\/jnnp-2012-304436-25","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1136\/jnnp.69.5.590","article-title":"Systematic review of acute levodopa and apomorphine challenge tests in the diagnosis of idiopathic Parkinson's disease","volume":"69","author":"Clarke","year":"2000","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2012-304436-26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1159\/000008142","article-title":"Acute challenge with apomorphine and levodopa in parkinsonism","volume":"43","author":"Rossi","year":"2000","journal-title":"Eur Neurol"},{"key":"key-10.1136\/jnnp-2012-304436-27","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/mds.10123","article-title":"Accuracy of acute levodopa challenge for clinical prediction of sustained long-term levodopa response as a major criterion for idiopathic Parkinson's disease diagnosis","volume":"17","author":"Merello","year":"2002","journal-title":"Mov Disord"},{"key":"key-10.1136\/jnnp-2012-304436-28","unstructured":"Parkinson's disease: Diagnosis and management in primary and secondary care. NICE clinical guideline 35. Developed by the National Collaborating Centre for Chronic Conditions. 2006. http:\/\/www.nice.org.uk\/nicemedia\/pdf\/cg035niceguideline.pdf (accessed 1 Jun 2006)."},{"key":"key-10.1136\/jnnp-2012-304436-29","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s004150070053","article-title":"Essential tremor: an overdiagnosed condition?","volume":"245","author":"Schrag","year":"2000","journal-title":"J Neurol"},{"key":"key-10.1136\/jnnp-2012-304436-30","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1001\/archneur.63.8.1100","article-title":"Common misdiagnosis of a common neurological disorder: how are we misdiagnosing essential tremor?","volume":"63","author":"Jain","year":"2006","journal-title":"Arch Neurol"},{"issue":"S3","key":"key-10.1136\/jnnp-2012-304436-31","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/mds.870131303","article-title":"Consensus statement of the movement disorder society on tremor","volume":"13","author":"Deuschl","year":"1998","journal-title":"Mov Disord"},{"key":"key-10.1136\/jnnp-2012-304436-32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/mds.23289","article-title":"Tremor\u2014some controversial aspects","volume":"26","author":"Quinn","year":"2011","journal-title":"Mov Disord"},{"key":"key-10.1136\/jnnp-2012-304436-33","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/mds.22937","article-title":"Differentiating vascular parkinsonism from idiopathic Parkinson's disease: a systematic review","volume":"23","author":"Kalra","year":"2010","journal-title":"Mov Disord"},{"key":"key-10.1136\/jnnp-2012-304436-34","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10072-003-0103-5","article-title":"123I-Ioflupane\/SPECT binding to striatal dopamine transporter (DAT) uptake in patients with Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy","volume":"24","author":"Antonini","year":"2003","journal-title":"Neurol Sci"},{"key":"key-10.1136\/jnnp-2012-304436-35","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2967\/jnumed.111.095224","article-title":"Subregional patterns of preferential striatal dopamine transporter loss differ in Parkinson disease, progressive supranuclear palsy, and multiple-system atrophy","volume":"53","author":"Oh","year":"2012","journal-title":"J Nucl Med"},{"key":"key-10.1136\/jnnp-2012-304436-36","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1212\/WNL.0b013e318248e520","article-title":"Role of DaTSCAN and clinical diagnosis in Parkinson disease","volume":"78","author":"de la Fuente-Fern\u00e1ndez","year":"2012","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2012-304436-37","article-title":"To scan or not to scan. DaT is the question","author":"Perlmutter","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2012-304436-38","article-title":"What is the false positive and negative rate of FP-CIT in clinical practice? Presented in Neuroimaging section, June 12, 2012, 16th International Movement Disorder Society Meeting","author":"Bajaj"},{"key":"key-10.1136\/jnnp-2012-304436-39","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/1531-8257(200005)15:3<503::AID-MDS1013>3.0.CO;2-V","article-title":"Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]-FP-CIT SPECT imaging: the [123I]-FP-CIT SPECT study group","volume":"15","author":"Benamer","year":"2000","journal-title":"Mov Disord"},{"key":"key-10.1136\/jnnp-2012-304436-40","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1136\/jnnp-2011-301695","article-title":"Impact of DaTscan\u2122 SPECT imaging on clinical management, diagnosis, confidence of diagnosis, quality of life, health resource use, and safety in patients with clinically uncertain parkinsonian syndromes: a prospective 1-year follow-up of an open-label controlled study","volume":"83","author":"Kupsch","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2012-304436-41","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/mds.20112","article-title":"Impact of dopamine transporter SPECT using 123 I\u2013Ioflupane on diagnosis and management of patients with clinically uncertain parkinsonian syndromes","volume":"19","author":"Catafau","year":"2004","journal-title":"Mov Disord"},{"key":"key-10.1136\/jnnp-2012-304436-42","unstructured":"British Nuclear Medicine Society Web Site. BNMS DaTSCAN Audit Launch. February 3, 2012. http:\/\/www.bnms.org.uk\/press-office\/bnms-datscan-audit-launch.html (accessed 2 Feb 2012)."},{"key":"key-10.1136\/jnnp-2012-304436-43","unstructured":"Annemans L . An assessment of the cost-effectiveness of DaTscan\u2122 SPECT for the diagnosis of patients with clinically uncertain parkinsonism. Health Economic Research Project, Health Economics Disease Management. 2003."},{"key":"key-10.1136\/jnnp-2012-304436-44","doi-asserted-by":"crossref","first-page":"A14","DOI":"10.1016\/S1098-3015(10)67183-5","article-title":"Economic evaluation of SPECT-DaTscan in the diagnosis of patients with clinically uncertain parkinsonism in Italy","volume":"8","author":"Busca","year":"2005","journal-title":"Value in Health"},{"key":"key-10.1136\/jnnp-2012-304436-45","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.crad.2006.10.013","article-title":"Initial clinical experience with [123I]ioflupane scintigraphy in movement disorders","volume":"62","author":"Manoharan","year":"2007","journal-title":"Clin Radiol."},{"key":"key-10.1136\/jnnp-2012-304436-46","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1007\/s00702-005-0401-6","article-title":"Possible impact of dopamine SPECT on decision-making for drug treatment in Parkinsonian syndrome","volume":"113","author":"Hesse","year":"2006","journal-title":"J Neural Transm"},{"key":"key-10.1136\/jnnp-2012-304436-47","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1007\/s00259-008-0777-2","article-title":"The cost effectiveness of 123I-FP-CIT SPECT imaging in patients with an uncertain clinical diagnosis of parkinsonism","volume":"35","author":"Van Laere","year":"2008","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"key-10.1136\/jnnp-2012-304436-48","doi-asserted-by":"crossref","first-page":"A15","DOI":"10.1016\/S1098-3015(10)67185-9","article-title":"Cost-effectiveness of non-invasive imaging in the diagnosis of parkinsonism","volume":"8","author":"Bruggenjurgen","year":"2005","journal-title":"Value in Health"},{"key":"key-10.1136\/jnnp-2012-304436-49","unstructured":"Westaway Gillis, Ltd. DaTscan\u2122 Budget Impact Model. 2005."},{"key":"key-10.1136\/jnnp-2012-304436-50","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1136\/jnnp.2006.098327","article-title":"A multicentre longitudinal observational study of changes in self reported health status in people with Parkinson's disease left untreated at diagnosis","volume":"78","author":"Grosset","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2012-304436-51","first-page":"S95","article-title":"Progressive deterioration in quality of life of untreated Parkinson's patients over 18\u2005months clinical follow up: results from the PDLIFE, a multi-centre prospective study of 401 patients","volume":"20","author":"Chaudhuri","year":"2005","journal-title":"Mov Disord"},{"key":"key-10.1136\/jnnp-2012-304436-52","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1053\/j.semnuclmed.2012.06.003","article-title":"Neuroimaging over the course of Parkinson's disease: from early detection of the at-risk patient to improving pharmacotherapy of later-stage disease","volume":"42","author":"Seibyl","year":"2012","journal-title":"Semin Nucl Med"},{"key":"key-10.1136\/jnnp-2012-304436-53","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/00019442-200201000-00005","article-title":"Age-related decline in dopamine transporters: analysis of striatal subregions, nonlinear effects, and hemispheric asymmetries","volume":"10","author":"van Dyck","year":"2002","journal-title":"Am J Geriatr Psychiatry"}],"container-title":["Journal of Neurology, Neurosurgery &amp; Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp-2012-304436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T17:51:39Z","timestamp":1601056299000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnnp.bmj.com\/lookup\/doi\/10.1136\/jnnp-2012-304436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,13]]},"references-count":53,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,10,9]]},"published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1136\/jnnp-2012-304436"],"URL":"https:\/\/doi.org\/10.1136\/jnnp-2012-304436","relation":{},"ISSN":["0022-3050","1468-330X"],"issn-type":[{"value":"0022-3050","type":"print"},{"value":"1468-330X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,13]]}}}