{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T12:53:11Z","timestamp":1783774391179,"version":"3.55.0"},"reference-count":33,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Neurol Neurosurg Psychiatry"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1136\/jnnp-2013-307314","type":"journal-article","created":{"date-parts":[[2014,5,24]],"date-time":"2014-05-24T01:43:29Z","timestamp":1400895809000},"page":"1301-1307","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":68,"title":["Hyperoxia may be related to delayed cerebral ischemia and poor outcome after subarachnoid haemorrhage"],"prefix":"10.1136","volume":"85","author":[{"given":"Sang-Beom","family":"Jeon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Alex","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Badjatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Michael","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Lantigua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Claassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E Sander","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan A","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiwon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2014,5,23]]},"reference":[{"key":"key-10.1136\/jnnp-2013-307314-1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/B0-44-306600-0\/50055-9","article-title":"Prehospital and emergency department care of the patient with acute stroke","volume-title":"Stroke: pathophysiology, diagnosis, and management","author":"Pancioli","year":"2004","edition":"4"},{"key":"key-10.1136\/jnnp-2013-307314-2","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1001\/jama.2010.707","article-title":"Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality","volume":"303","author":"Kilgannon","year":"2010","journal-title":"JAMA"},{"key":"key-10.1136\/jnnp-2013-307314-3","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1001\/archsurg.2012.1560","article-title":"Association between early hyperoxia and worse outcomes after traumatic brain injury","volume":"147","author":"Brenner","year":"2012","journal-title":"Arch Surg"},{"key":"key-10.1136\/jnnp-2013-307314-4","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3171\/jns.2004.101.3.0435","article-title":"Normobaric hyperoxia-induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study","volume":"101","author":"Tolias","year":"2004","journal-title":"J Neurosurgery"},{"key":"key-10.1136\/jnnp-2013-307314-5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/jns.1999.91.1.0001","article-title":"Increased inspired oxygen concentration as a factor in improved brain tissue oxygenation and tissue lactate levels after severe human head injury","volume":"91","author":"Menzel","year":"1999","journal-title":"J Neurosurgery"},{"key":"key-10.1136\/jnnp-2013-307314-6","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1161\/01.STR.0000158914.66827.2e","article-title":"A pilot study of normobaric oxygen therapy in acute ischemic stroke","volume":"36","author":"Singhal","year":"2005","journal-title":"Stroke"},{"key":"key-10.1136\/jnnp-2013-307314-7","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1161\/STROKEAHA.107.487280","article-title":"Magnetic resonance spectroscopy study of oxygen therapy in ischemic stroke","volume":"38","author":"Singhal","year":"2007","journal-title":"Stroke"},{"key":"key-10.1136\/jnnp-2013-307314-8","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.siny.2010.04.003","article-title":"Oxygen toxicity: chemistry and biology of reactive oxygen species","volume":"15","author":"Buonocore","year":"2010","journal-title":"Semin Fetal Neonatal Med"},{"key":"key-10.1136\/jnnp-2013-307314-9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cardiores.2003.10.025","article-title":"New concepts in reactive oxygen species and cardiovascular reperfusion physiology","volume":"61","author":"Becker","year":"2004","journal-title":"Cardiovasc Res"},{"key":"key-10.1136\/jnnp-2013-307314-10","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1152\/japplphysiol.00303.2003","article-title":"Independent cerebral vasoconstrictive effects of hyperoxia and accompanying arterial hypocapnia at 1 ATA","volume":"95","author":"Floyd","year":"2003","journal-title":"J Appl Physiol"},{"key":"key-10.1136\/jnnp-2013-307314-11","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1097\/00003246-200612002-00426","article-title":"Impact of medical complications on outcome after subarachnoid hemorrhage","volume":"34","author":"Wartenberg","year":"2006","journal-title":"Crit Care Med"},{"key":"key-10.1136\/jnnp-2013-307314-12","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1161\/STROKEAHA.111.623165","article-title":"Multimodality monitoring for cerebral perfusion pressure optimization in comatose patients with intracerebral hemorrhage","volume":"42","author":"Ko","year":"2011","journal-title":"Stroke"},{"key":"key-10.1136\/jnnp-2013-307314-13","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1161\/hs0901.095677","article-title":"Effect of cisternal and ventricular blood on risk of delayed cerebral ischemia after subarachnoid hemorrhage: the Fisher scale revisited","volume":"32","author":"Claassen","year":"2001","journal-title":"Stroke"},{"key":"key-10.1136\/jnnp-2013-307314-14","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1161\/01.STR.0000015624.29071.1F","article-title":"Global cerebral edema after subarachnoid hemorrhage: frequency, predictors, and impact on outcome","volume":"33","author":"Claassen","year":"2002","journal-title":"Stroke"},{"key":"key-10.1136\/jnnp-2013-307314-15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1212\/WNL.0b013e31823ed0a4","article-title":"Effect of rebleeding on the course and incidence of vasospasm after subarachnoid hemorrhage","volume":"78","author":"Lord","year":"2012","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2013-307314-16","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1161\/STROKEAHA.108.544700","article-title":"Defining vasospasm after subarachnoid hemorrhage: what is the most clinically relevant definition?","volume":"40","author":"Frontera","year":"2009","journal-title":"Stroke"},{"key":"key-10.1136\/jnnp-2013-307314-17","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s00134-010-2025-z","article-title":"Clinicians\u2019 response to hyperoxia in ventilated patients in a Dutch ICU depends on the level of FiO2","volume":"37","author":"de Graaff","year":"2011","journal-title":"Intensive Care Med"},{"key":"key-10.1136\/jnnp-2013-307314-18","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1378\/chest.88.6.900","article-title":"Pulmonary oxygen toxicity","volume":"88","author":"Jackson","year":"1985","journal-title":"Chest"},{"key":"key-10.1136\/jnnp-2013-307314-19","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1164\/ajrccm.155.2.9032182","article-title":"Plasma hypoxanthine levels in ARDS: implications for oxidative stress, morbidity, and mortality","volume":"155","author":"Quinlan","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"key-10.1136\/jnnp-2013-307314-20","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1378\/chest.101.2.392","article-title":"Hyperoxic exposure in humans. Effects of 50 percent oxygen on alveolar macrophage leukotriene B4 synthesis","volume":"101","author":"Griffith","year":"1992","journal-title":"Chest"},{"key":"key-10.1136\/jnnp-2013-307314-21","doi-asserted-by":"crossref","first-page":"S559","DOI":"10.1097\/CCM.0b013e3181f1fe70","article-title":"Hyperoxia may be beneficial","volume":"38","author":"Calzia","year":"2010","journal-title":"Crit Care Med"},{"key":"key-10.1136\/jnnp-2013-307314-22","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1089\/neu.2009.1186","article-title":"Hyperoxic reperfusion after global cerebral ischemia promotes inflammation and long-term hippocampal neuronal death","volume":"27","author":"Hazelton","year":"2010","journal-title":"J Neurotrauma"},{"key":"key-10.1136\/jnnp-2013-307314-23","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1046\/j.1365-2346.2000.00640.x","article-title":"The effect of hyperoxia on cerebral blood flow: a study in healthy volunteers using magnetic resonance phase-contrast angiography","volume":"17","author":"Watson","year":"2000","journal-title":"Eur J Anaesthesiol"},{"key":"key-10.1136\/jnnp-2013-307314-24","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1365-201X.2005.01405.x","article-title":"Acute hyperoxaemia-induced effects on regional blood flow, oxygen consumption and central circulation in man","volume":"183","author":"Rousseau","year":"2005","journal-title":"Acta Physiol Scand"},{"key":"key-10.1136\/jnnp-2013-307314-25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1747-4949.2006.00058.x","article-title":"Oxygen therapy in stroke: past, present, and future","volume":"1","author":"Singhal","year":"2006","journal-title":"Int J Stroke"},{"key":"key-10.1136\/jnnp-2013-307314-26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.expneurol.2009.04.030","article-title":"Mitochondrial mechanisms of cell death and neuroprotection in pediatric ischemic and traumatic brain injury","volume":"218","author":"Robertson","year":"2009","journal-title":"Exp Neurol"},{"key":"key-10.1136\/jnnp-2013-307314-27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2009.02.001","article-title":"Microglia-aging: roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging","volume":"201","author":"Nakanishi","year":"2009","journal-title":"Behav Brain Res"},{"key":"key-10.1136\/jnnp-2013-307314-28","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1056\/NEJM196611102751903","article-title":"Pathologic effects of exposure to high oxygen tensions. A review","volume":"275","author":"Balentine","year":"1966","journal-title":"N Engl J Med"},{"key":"key-10.1136\/jnnp-2013-307314-29","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2174\/15672026113109990003","article-title":"The role of oxidative stress in cerebral aneurysm formation and rupture","volume":"10","author":"Starke","year":"2013","journal-title":"Curr Neurovasc Res"},{"key":"key-10.1136\/jnnp-2013-307314-30","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1089\/neu.2009.0940","article-title":"Both hypoxemia and extreme hyperoxemia may be detrimental in patients with severe traumatic brain injury","volume":"26","author":"Davis","year":"2009","journal-title":"J Neurotrauma"},{"key":"key-10.1136\/jnnp-2013-307314-31","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1227\/00006123-198209000-00001","article-title":"Treatment of ischemic deficits from vasospasm with intravascular volume expansion and induced arterial hypertension","volume":"11","author":"Kassell","year":"1982","journal-title":"Neurosurgery"},{"key":"key-10.1136\/jnnp-2013-307314-32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1001\/archneurol.2010.226","article-title":"Spreading depolarization: a possible new culprit in the delayed cerebral ischemia of subarachnoid hemorrhage","volume":"68","author":"Leng","year":"2011","journal-title":"Arch Neurol"},{"key":"key-10.1136\/jnnp-2013-307314-33","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1172\/JCI119089","article-title":"Plasminogen activator inhibitor-1 in acute hyperoxic mouse lung injury","volume":"98","author":"Barazzone","year":"1996","journal-title":"J Clin Invest"}],"container-title":["Journal of Neurology, Neurosurgery & Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp-2013-307314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T13:55:40Z","timestamp":1601042140000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnnp.bmj.com\/lookup\/doi\/10.1136\/jnnp-2013-307314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,23]]},"references-count":33,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,11,17]]},"published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1136\/jnnp-2013-307314"],"URL":"https:\/\/doi.org\/10.1136\/jnnp-2013-307314","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726388089.793519078","asserted-by":"object"}]},"ISSN":["0022-3050","1468-330X"],"issn-type":[{"value":"0022-3050","type":"print"},{"value":"1468-330X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,23]]}}}