{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:32:29Z","timestamp":1789716749120,"version":"4.0.1"},"reference-count":36,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Neurol Neurosurg Psychiatry"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1136\/jnnp-2014-308094","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T04:34:08Z","timestamp":1403843648000},"page":"431-436","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":91,"title":["A\u03b2 imaging with 18F-florbetaben in prodromal Alzheimer's disease: a prospective outcome study"],"prefix":"10.1136","volume":"86","author":[{"given":"Kevin T","family":"Ong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L","family":"Villemagne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Bahar-Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Lamb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narelle","family":"Langdon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M","family":"Catafau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Seibyl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludger M","family":"Dinkelborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia B","family":"Reininger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Putz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Rohde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L","family":"Masters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2014,6,26]]},"reference":[{"key":"key-10.1136\/jnnp-2014-308094-1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/ana.20009","article-title":"Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B","volume":"55","author":"Klunk","year":"2004","journal-title":"Ann Neurol"},{"key":"key-10.1136\/jnnp-2014-308094-2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/alzrt93","article-title":"Amyloid imaging in the differential diagnosis of dementia: review and potential clinical applications","volume":"3","author":"Laforce","year":"2011","journal-title":"Alzheimers Res Ther"},{"key":"key-10.1136\/jnnp-2014-308094-3","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1212\/01.wnl.0000261919.22630.ea","article-title":"Imaging beta-amyloid burden in aging and dementia","volume":"68","author":"Rowe","year":"2007","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2014-308094-4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/alzrt62","article-title":"Amyloid imaging and memory change for prediction of cognitive impairment","volume":"3","author":"Resnick","year":"2011","journal-title":"Alzheimers Res Ther"},{"key":"key-10.1136\/jnnp-2014-308094-5","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement"},{"key":"key-10.1136\/jnnp-2014-308094-6","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S1474-4422(10)70223-4","article-title":"Revising the definition of Alzheimer's disease: a new lexicon","volume":"9","author":"Dubois","year":"2010","journal-title":"Lancet Neurol"},{"key":"key-10.1136\/jnnp-2014-308094-7","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1212\/WNL.0b013e3182661f74","article-title":"Amyloid-beta assessed by florbetapir F 18 PET and 18-month cognitive decline: a multicenter study","volume":"79","author":"Doraiswamy","year":"2012","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2014-308094-8","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2014-308094-9"},{"key":"key-10.1136\/jnnp-2014-308094-10","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/ana.24040","article-title":"Predicting Alzheimer disease with beta-amyloid imaging: results from the Australian imaging, biomarkers, and lifestyle study of ageing","volume":"74","author":"Rowe","year":"2013","journal-title":"Ann Neurol"},{"key":"key-10.1136\/jnnp-2014-308094-11","doi-asserted-by":"crossref","first-page":"5980","DOI":"10.1021\/jm050166g","article-title":"F-18 stilbenes as PET imaging agents for detecting beta-amyloid plaques in the brain","volume":"48","author":"Zhang","year":"2005","journal-title":"J Med Chem"},{"key":"key-10.1136\/jnnp-2014-308094-12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1474-4422(08)70001-2","article-title":"Imaging of amyloid beta in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism","volume":"7","author":"Rowe","year":"2008","journal-title":"Lancet Neurol"},{"key":"key-10.1136\/jnnp-2014-308094-13","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S1474-4422(11)70077-1","article-title":"Cerebral amyloid-beta PET with florbetaben ((18)F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study","volume":"10","author":"Barthel","year":"2011","journal-title":"Lancet Neurol"},{"key":"key-10.1136\/jnnp-2014-308094-14","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.2967\/jnumed.111.089730","article-title":"Amyloid imaging with 18F-florbetaben in Alzheimer disease and other dementias","volume":"52","author":"Villemagne","year":"2011","journal-title":"J Nucl Med"},{"key":"key-10.1136\/jnnp-2014-308094-15","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s00259-012-2088-x","article-title":"Comparison of 11C-PiB and 18F-florbetaben for Abeta imaging in ageing and Alzheimer's disease","volume":"39","author":"Villemagne","year":"2012","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"(4 Suppl)","key":"key-10.1136\/jnnp-2014-308094-16","doi-asserted-by":"crossref","first-page":"P90","DOI":"10.1016\/j.jalz.2012.05.220","article-title":"Multicentre phase 3 trial on florbetaben for beta-amyloid brain PET in Alzheimer's disease","volume":"8","author":"Sabbagh","year":"2012","journal-title":"Alzheimer Demen"},{"key":"key-10.1136\/jnnp-2014-308094-17","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1001\/archneur.63.5.674","article-title":"Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia","volume":"63","author":"Jicha","year":"2006","journal-title":"Arch Neurol"},{"key":"key-10.1136\/jnnp-2014-308094-18","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1016\/j.jalz.2010.05.074","article-title":"Assessment of A\u03b2 deposition in mild cognitive impairment with 18F-florbetaben","volume":"6","author":"Ong","year":"2010","journal-title":"Alzheimer Demen"},{"issue":"(Pt 5)","key":"key-10.1136\/jnnp-2014-308094-19","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/brain\/awn320","article-title":"Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects","volume":"132","author":"Mormino","year":"2009","journal-title":"Brain"},{"key":"key-10.1136\/jnnp-2014-308094-20","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","article-title":"Amyloid beta deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study","volume":"12","author":"Villemagne","year":"2013","journal-title":"Lancet Neurol"},{"key":"key-10.1136\/jnnp-2014-308094-21","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3233\/JAD-2012-121315","article-title":"Prediction of amyloid-beta pathology in amnestic mild cognitive impairment with neuropsychological tests","volume":"33","author":"Bahar-Fuchs","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"key-10.1136\/jnnp-2014-308094-22","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","article-title":"Mild cognitive impairment as a diagnostic entity","volume":"256","author":"Petersen","year":"2004","journal-title":"J Intern Med"},{"key":"key-10.1136\/jnnp-2014-308094-23","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1365-2796.2004.01380.x","article-title":"Mild cognitive impairment\u2014beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment","volume":"256","author":"Winblad","year":"2004","journal-title":"J Intern Med"},{"key":"key-10.1136\/jnnp-2014-308094-24","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2014-308094-25","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1212\/WNL.47.5.1113","article-title":"Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop","volume":"47","author":"McKeith","year":"1996","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2014-308094-26","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","article-title":"Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria","volume":"51","author":"Neary","year":"1998","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2014-308094-27","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1212\/WNL.44.11.2015","article-title":"Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy)","volume":"44","author":"Hauw","year":"1994","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2014-308094-28","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1017\/S1041610209009405","article-title":"The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease","volume":"21","author":"Ellis","year":"2009","journal-title":"Int Psychogeriatr"},{"key":"key-10.1136\/jnnp-2014-308094-29","first-page":"548157","article-title":"Florbetaben PET in the early diagnosis of Alzheimer's disease: a discrete event simulation to explore its potential value and key data gaps","volume":"2012","author":"Guo","year":"2012","journal-title":"Int J Alzheimers Dis"},{"key":"key-10.1136\/jnnp-2014-308094-30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s00259-012-2237-2","article-title":"A European multicentre PET study of fibrillar amyloid in Alzheimer's disease","volume":"40","author":"Nordberg","year":"2013","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"key-10.1136\/jnnp-2014-308094-31","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1212\/WNL.0b013e3181b23564","article-title":"Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study","volume":"73","author":"Okello","year":"2009","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2014-308094-32","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/ana.21598","article-title":"Amyloid imaging in mild cognitive impairment subtypes","volume":"65","author":"Wolk","year":"2009","journal-title":"Ann Neurol"},{"key":"key-10.1136\/jnnp-2014-308094-33","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1212\/WNL.0b013e31829d86e8","article-title":"Imaging markers for Alzheimer disease: which vs how","volume":"81","author":"Frisoni","year":"2013","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2014-308094-34","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1212\/WNL.58.5.750","article-title":"Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia","volume":"58","author":"Jack","year":"2002","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2014-308094-35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade","volume":"9","author":"Jack","year":"2010","journal-title":"Lancet Neurol"},{"key":"key-10.1136\/jnnp-2014-308094-36","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1212\/WNL.0b013e3182840bbe","article-title":"Brain beta-amyloid load approaches a plateau","volume":"80","author":"Jack","year":"2013","journal-title":"Neurology"}],"container-title":["Journal of Neurology, Neurosurgery & Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp-2014-308094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T17:56:11Z","timestamp":1601056571000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnnp.bmj.com\/lookup\/doi\/10.1136\/jnnp-2014-308094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,26]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,3,13]]},"published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1136\/jnnp-2014-308094"],"URL":"https:\/\/doi.org\/10.1136\/jnnp-2014-308094","relation":{},"ISSN":["0022-3050","1468-330X"],"issn-type":[{"value":"0022-3050","type":"print"},{"value":"1468-330X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,26]]}}}