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For these neuropathies, the classification in demyelinating and axonal is inadequate or even misleading, we therefore propose a new category of nodopathy that has the following features: (1) it is characterised by a pathophysiological continuum from transitory nerve conduction block to axonal degeneration; (2) the conduction block may be due to paranodal myelin detachment, node lengthening, dysfunction or disruption of Na<jats:sup>+<\/jats:sup>channels, altered homeostasis of water and ions, or abnormal polarisation of the axolemma; (3) the conduction block may be promptly reversible without development of excessive temporal dispersion; (4) axonal degeneration, depending on the specific disorder and its severity, eventually follows the conduction block. The term nodopathy focuses to the site of primary nerve injury, avoids confusion with segmental demyelinating neuropathies and circumvents the apparent paradox that something axonal may be reversible and have a good prognosis.<\/jats:p>","DOI":"10.1136\/jnnp-2014-310097","type":"journal-article","created":{"date-parts":[[2015,2,21]],"date-time":"2015-02-21T06:43:52Z","timestamp":1424501032000},"page":"1186-1195","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":155,"title":["Nodopathies of the peripheral nerve: an emerging concept"],"prefix":"10.1136","volume":"86","author":[{"given":"Antonino","family":"Uncini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4716-8578","authenticated-orcid":false,"given":"Satoshi","family":"Kuwabara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,2,19]]},"reference":[{"key":"key-10.1136\/jnnp-2014-310097-1","first-page":"1168","article-title":"Contributions \u00e0 l'histologie et \u00e0 la physiologie des nerfs p\u00e9riph\u00e9riques","volume":"73","author":"Ranvier","year":"1871","journal-title":"Comptes Rendus de l'Acad\u00e9mie des Sciences"},{"key":"key-10.1136\/jnnp-2014-310097-2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1113\/jphysiol.1949.sp004335","article-title":"Evidence for saltatory conduction in peripheral myelinated nerve fibers","volume":"108","author":"Huxley","year":"1949","journal-title":"J Physiol"},{"key":"key-10.1136\/jnnp-2014-310097-3","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/j.clinph.2013.03.025","article-title":"Nodo-paranodopathy: beyond the demyelinating and axonal classification in anti-ganglioside antibody-mediated neuropathies","volume":"124","author":"Uncini","year":"2013","journal-title":"Clin Neurophysiol"},{"key":"key-10.1136\/jnnp-2014-310097-4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1042\/AN20130025","article-title":"Node of Ranvier disruption as a cause of neurological diseases","volume":"5","author":"Susuki","year":"2013","journal-title":"ASN Neuro"},{"key":"key-10.1136\/jnnp-2014-310097-5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ana.410330202","article-title":"Molecular dissection of the myelinated axon","volume":"33","author":"Waxman","year":"1993","journal-title":"Ann Neurol"},{"key":"key-10.1136\/jnnp-2014-310097-6","doi-asserted-by":"crossref","first-page":"5616","DOI":"10.1073\/pnas.090034797","article-title":"Sodium channel Na(v)1.6 is localized at nodes of Ranvier, dendrites, and synapses","volume":"97","author":"Caldwell","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"key-10.1136\/jnnp-2014-310097-7","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1124\/pr.57.4.10","article-title":"International Union of Pharmacology. 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