{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:10:12Z","timestamp":1790482212961,"version":"4.1.0"},"reference-count":47,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Neurol Neurosurg Psychiatry"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1136\/jnnp-2015-312413","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T03:59:06Z","timestamp":1454385546000},"page":"975-981","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":64,"title":["Hippocampal dysfunction defines disease onset in Huntington's disease"],"prefix":"10.1136","volume":"87","author":[{"given":"Faye","family":"Begeti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia C","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,2,1]]},"reference":[{"key":"key-10.1136\/jnnp-2015-312413-1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington's disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"key":"key-10.1136\/jnnp-2015-312413-2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mds.870110204","article-title":"Unified Huntington's Disease Rating Scale: reliability and consistency","volume":"11","author":"Huntington Study Group","year":"1996","journal-title":"Mov Disord"},{"key":"key-10.1136\/jnnp-2015-312413-3","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1093\/brain\/121.7.1329","article-title":"Evidence for specific cognitive deficits in preclinical Huntington's disease","volume":"121","author":"Lawrence","year":"1998","journal-title":"Brain"},{"key":"key-10.1136\/jnnp-2015-312413-4","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1212\/01.WNL.0000098878.47789.BD","article-title":"Profile of cognitive progression in early Huntington's disease","volume":"61","author":"Ho","year":"2003","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2015-312413-5","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1212\/01.wnl.0000174432.87383.87","article-title":"Regional cortical thinning in preclinical Huntington disease and its relationship to cognition","volume":"65","author":"Rosas","year":"2005","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2015-312413-6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1076\/jcen.24.2.133.998","article-title":"Psychomotor, executive, and memory function in preclinical Huntington's disease","volume":"24","author":"Snowden","year":"2002","journal-title":"J Clin Exp Neuropsychol"},{"key":"key-10.1136\/jnnp-2015-312413-7","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1037\/0894-4105.22.5.596","article-title":"Phonemic fluency deficits in asymptomatic gene carriers for Huntington's disease","volume":"22","author":"Larsson","year":"2008","journal-title":"Neuropsychology"},{"key":"key-10.1136\/jnnp-2015-312413-8","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1111\/j.1468-1331.2008.02253.x","article-title":"Altered frontostriatal coupling in pre-manifest Huntington's disease: effects of increasing cognitive load","volume":"15","author":"Wolf","year":"2008","journal-title":"Eur J Neurol"},{"key":"key-10.1136\/jnnp-2015-312413-9","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1212\/01.WNL.0000065888.88988.6E","article-title":"Evidence for more widespread cerebral pathology in early HD","volume":"60","author":"Rosas","year":"2003","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2015-312413-10","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s00415-010-5768-0","article-title":"Early atrophy of pallidum and accumbens nucleus in Huntington's disease","volume":"258","author":"van den Bogaard","year":"2011","journal-title":"J Neurol"},{"key":"key-10.1136\/jnnp-2015-312413-11","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nrn2335","article-title":"The hippocampus and memory: insights from spatial processing","volume":"9","author":"Bird","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"key-10.1136\/jnnp-2015-312413-12","doi-asserted-by":"crossref","first-page":"11564","DOI":"10.1523\/JNEUROSCI.3796-05.2005","article-title":"Abnormalities of neurogenesis in the R6\/2 mouse model of Huntington's disease are attributable to the in vivo microenvironment","volume":"25","author":"Phillips","year":"2005","journal-title":"J Neurosci"},{"key":"key-10.1136\/jnnp-2015-312413-13","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/hmg\/8.5.839","article-title":"Impaired synaptic plasticity in mice carrying the Huntington's disease mutation","volume":"8","author":"Usdin","year":"1999","journal-title":"Hum Mol Genet"},{"key":"key-10.1136\/jnnp-2015-312413-14","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1111\/j.1460-9568.2006.04715.x","article-title":"Neurogenesis in the R6\/1 transgenic mouse model of Huntington's disease: effects of environmental enrichment","volume":"23","author":"Lazic","year":"2006","journal-title":"Eur J Neurosci"},{"key":"key-10.1136\/jnnp-2015-312413-15","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.brainres.2011.06.040","article-title":"Neurogenesis in Huntington's disease: Can studying adult neurogenesis lead to the development of new therapeutic strategies?","volume":"1406","author":"Gil-Mohapel","year":"2011","journal-title":"Brain Res"},{"key":"key-10.1136\/jnnp-2015-312413-16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.nbd.2010.09.012","article-title":"Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease","volume":"41","author":"Simpson","year":"2011","journal-title":"Neurobiol Dis"},{"key":"key-10.1136\/jnnp-2015-312413-17","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1523\/JNEUROSCI.20-13-05115.2000","article-title":"Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation","volume":"20","author":"Murphy","year":"2000","journal-title":"J Neurosci"},{"key":"key-10.1136\/jnnp-2015-312413-18","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3233\/JHD-120023","article-title":"Cognitive dysfunction in Huntington's disease: humans, mouse models and molecular mechanisms","volume":"1","author":"Giralt","year":"2012","journal-title":"J Huntingtons Dis"},{"key":"key-10.1136\/jnnp-2015-312413-19","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1023\/A:1010887421592","article-title":"Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntingtons disease mutation","volume":"29","author":"Morton","year":"2000","journal-title":"J Neurocytol"},{"key":"key-10.1136\/jnnp-2015-312413-20","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1136\/jnnp.56.5.487","article-title":"Neuronal loss in the hippocampus in Huntington's disease: a comparison with HIV infection","volume":"56","author":"Spargo","year":"1993","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2015-312413-21","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0166-4328(01)00399-0","article-title":"Humans with hippocampus damage display severe spatial memory impairments in a virtual Morris water task","volume":"132","author":"Astur","year":"2002","journal-title":"Behav Brain Res"},{"key":"key-10.1136\/jnnp-2015-312413-22","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"J Neurosci Methods"},{"key":"key-10.1136\/jnnp-2015-312413-23","first-page":"266","article-title":"Cambridge Neuropsychological Test Automated Battery (CANTAB): a factor analytic study of a large sample of normal elderly volunteers","volume":"5","author":"Robbins","year":"1994","journal-title":"Dementia"},{"key":"key-10.1136\/jnnp-2015-312413-24","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/ana.410410521","article-title":"CAG repeat number governs the development rate of pathology in Huntington's disease","volume":"41","author":"Penney","year":"1997","journal-title":"Ann Neurol"},{"key":"key-10.1136\/jnnp-2015-312413-25","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1399-0004.2004.00241.x","article-title":"A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length","volume":"65","author":"Langbehn","year":"2004","journal-title":"Clin Genet"},{"key":"key-10.1136\/jnnp-2015-312413-26","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1474-4422(09)70170-X","article-title":"Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data","volume":"8","author":"Tabrizi","year":"2009","journal-title":"Lancet Neurol"},{"key":"key-10.1136\/jnnp-2015-312413-27","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1016\/j.cortex.2013.05.015","article-title":"Prefrontal executive function associated coupling relates to Huntington's disease stage","volume":"49","author":"Unschuld","year":"2013","journal-title":"Cortex"},{"key":"key-10.1136\/jnnp-2015-312413-28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/35041572","article-title":"Distinct functions of the two isoforms of dopamine D2 receptors","volume":"408","author":"Usiello","year":"2000","journal-title":"Nature"},{"key":"key-10.1136\/jnnp-2015-312413-29","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1159\/000051269","article-title":"Early detection and differential diagnosis of Alzheimer's disease and depression with neuropsychological tasks","volume":"12","author":"Swainson","year":"2001","journal-title":"Dement Geriatr Cogn Disord"},{"key":"key-10.1136\/jnnp-2015-312413-30","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000074081","article-title":"Detecting dementia: novel neuropsychological markers of preclinical Alzheimer's disease","volume":"17","author":"Blackwell","year":"2004","journal-title":"Dement Geriatr Cogn Disord"},{"key":"key-10.1136\/jnnp-2015-312413-31","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.brainresbull.2011.01.010","article-title":"Longitudinal analysis of the behavioural phenotype in R6\/1 (C57BL\/6J) Huntington's disease transgenic mice","volume":"88","author":"Brooks","year":"2012","journal-title":"Brain Res Bull"},{"key":"key-10.1136\/jnnp-2015-312413-32","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/297681a0","article-title":"Place navigation impaired in rats with hippocampal lesions","volume":"297","author":"Morris","year":"1982","journal-title":"Nature"},{"key":"key-10.1136\/jnnp-2015-312413-33","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/23941","article-title":"Hippocampal lesions disrupt navigation based on cognitive maps but not heading vectors","volume":"396","author":"Pearce","year":"1998","journal-title":"Nature"},{"key":"key-10.1136\/jnnp-2015-312413-34","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.bbr.2009.12.035","article-title":"Selective temporal resections and spatial memory impairment: cue dependent lateralization effects","volume":"208","author":"Barkas","year":"2010","journal-title":"Behav Brain Res"},{"issue":"(Pt 8)","key":"key-10.1136\/jnnp-2015-312413-35","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1093\/brain\/aws176","article-title":"Fluoxetine restores spatial learning but not accelerated forgetting in mesial temporal lobe epilepsy","volume":"135","author":"Barkas","year":"2012","journal-title":"Brain"},{"key":"key-10.1136\/jnnp-2015-312413-36","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/cercor\/bhg081","article-title":"The aging hippocampus: cognitive, biochemical and structural findings","volume":"13","author":"Driscoll","year":"2003","journal-title":"Cereb Cortex"},{"key":"key-10.1136\/jnnp-2015-312413-37","doi-asserted-by":"crossref","first-page":"5983","DOI":"10.1523\/JNEUROSCI.5001-07.2008","article-title":"Human hippocampal and parahippocampal theta during goal-directed spatial navigation predicts performance on a virtual Morris water maze","volume":"28","author":"Cornwell","year":"2008","journal-title":"J Neurosci"},{"key":"key-10.1136\/jnnp-2015-312413-38","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neuroscience.2004.07.043","article-title":"Differential contribution of dopamine D2S and D2 L receptors in the modulation of glutamate and GABA transmission in the striatum","volume":"129","author":"Centonze","year":"2004","journal-title":"Neuroscience"},{"key":"key-10.1136\/jnnp-2015-312413-39","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s00213-006-0347-x","article-title":"Differential contributions of dopaminergic D1- and D2-like receptors to cognitive function in rhesus monkeys","volume":"188","author":"Von Huben","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"key-10.1136\/jnnp-2015-312413-40","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00213-009-1526-3","article-title":"A novel touchscreen-automated paired-associate learning (PAL) task sensitive to pharmacological manipulation of the hippocampus: a translational rodent model of cognitive impairments in neurodegenerative disease","volume":"205","author":"Talpos","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"key-10.1136\/jnnp-2015-312413-41","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00213-010-2050-1","article-title":"A computer-automated touchscreen paired-associates learning (PAL) task for mice: impairments following administration of scopolamine or dicyclomine and improvements following donepezil","volume":"214","author":"Bartko","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"key":"key-10.1136\/jnnp-2015-312413-42","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0010-9452(08)70107-2","article-title":"Recognition memory for hand positions and spatial locations in patients with Huntington's disease: differential visuospatial memory impairment?","volume":"39","author":"Davis","year":"2003","journal-title":"Cortex"},{"key":"key-10.1136\/jnnp-2015-312413-43","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jns.2011.08.016","article-title":"Disturbance of real space navigation in moderately advanced but not in early Huntington's disease","volume":"312","author":"Majerova","year":"2012","journal-title":"J Neurol Sci"},{"key":"key-10.1136\/jnnp-2015-312413-44","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1136\/jnnp.58.5.598","article-title":"Comparison of executive and visuospatial memory function in Huntington's disease and dementia of Alzheimer type matched for degree of dementia","volume":"58","author":"Lange","year":"1995","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2015-312413-45","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/brain\/119.5.1633","article-title":"Executive and mnemonic functions in early Huntington's disease","volume":"119","author":"Lawrence","year":"1996","journal-title":"Brain"},{"issue":"(Pt 7)","key":"key-10.1136\/jnnp-2015-312413-46","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1093\/brain\/123.7.1349","article-title":"Visual object and visuospatial cognition in Huntington's disease: implications for information processing in corticostriatal circuits","volume":"123","author":"Lawrence","year":"2000","journal-title":"Brain"},{"key":"key-10.1136\/jnnp-2015-312413-47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0028-3932(94)00098-A","article-title":"Visuo-spatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalo-hippocampectomy in man","volume":"33","author":"Owen","year":"1995","journal-title":"Neuropsychologia"}],"container-title":["Journal of Neurology, Neurosurgery &amp; Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp-2015-312413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T18:03:07Z","timestamp":1601056987000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnnp.bmj.com\/lookup\/doi\/10.1136\/jnnp-2015-312413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,1]]},"references-count":47,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,8,12]]},"published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1136\/jnnp-2015-312413"],"URL":"https:\/\/doi.org\/10.1136\/jnnp-2015-312413","relation":{},"ISSN":["0022-3050","1468-330X"],"issn-type":[{"value":"0022-3050","type":"print"},{"value":"1468-330X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,1]]}}}