{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:03:53Z","timestamp":1789923833358,"version":"4.0.1"},"reference-count":28,"publisher":"BMJ","issue":"1","funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CG\/NUHS\/2010"],"award-info":[{"award-number":["NMRC\/CG\/NUHS\/2010"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CSA\/038\/2013"],"award-info":[{"award-number":["NMRC\/CSA\/038\/2013"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Neurol Neurosurg Psychiatry"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1136\/jnnp-2016-313271","type":"journal-article","created":{"date-parts":[[2016,6,4]],"date-time":"2016-06-04T02:44:10Z","timestamp":1465008250000},"page":"7-11","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Cerebral microbleeds and neuropsychiatric symptoms in an elderly Asian cohort"],"prefix":"10.1136","volume":"88","author":[{"given":"Xin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun Lin","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Hilal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Win King","family":"Goh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Kamran","family":"Ikram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien Yin","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Yu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Li-Hsian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayanaswamy","family":"Venketasubramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,6,3]]},"reference":[{"key":"key-10.1136\/jnnp-2016-313271-1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/WAD.0000000000000015","article-title":"Cerebral microbleeds and cognition: the epidemiology of dementia in Singapore study","volume":"28","author":"Hilal","year":"2014","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"key-10.1136\/jnnp-2016-313271-2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000333482","article-title":"Cerebral small vessel disease: cognition, mood, daily functioning, and imaging findings from a small pilot sample","volume":"2","author":"Baker","year":"2012","journal-title":"Dement Geriatr Cogn Dis Extra"},{"key":"key-10.1136\/jnnp-2016-313271-3","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1161\/STROKEAHA.112.670216","article-title":"Cerebral microbleeds and cognition in patients with symptomatic small vessel disease","volume":"44","author":"Patel","year":"2013","journal-title":"Stroke"},{"key":"key-10.1136\/jnnp-2016-313271-4","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1159\/000362590","article-title":"Cerebral microbleeds are associated with the progression of ischemic vascular lesions","volume":"37","author":"Akoudad","year":"2014","journal-title":"Cerebrovasc Dis"},{"key":"key-10.1136\/jnnp-2016-313271-5","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/nan.12062","article-title":"Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds","volume":"40","author":"Janaway","year":"2014","journal-title":"Neuropathol Appl Neurobiol"},{"key":"key-10.1136\/jnnp-2016-313271-6","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1016\/j.neurobiolaging.2013.01.002","article-title":"The effects of small vessel disease and amyloid burden on neuropsychiatric symptoms: a study among patients with subcortical vascular cognitive impairments","volume":"34","author":"Kim","year":"2013","journal-title":"Neurobiol Aging"},{"key":"key-10.1136\/jnnp-2016-313271-7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1161\/STROKEAHA.113.002686","article-title":"Cerebral microbleeds as a predictor of 1-year outcome of poststroke depression","volume":"45","author":"Tang","year":"2014","journal-title":"Stroke"},{"key":"key-10.1136\/jnnp-2016-313271-8","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1161\/STROKEAHA.111.614586","article-title":"Cerebral microbleeds and depression in lacunar stroke","volume":"42","author":"Tang","year":"2011","journal-title":"Stroke"},{"key":"key-10.1136\/jnnp-2016-313271-9","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/(SICI)1099-1166(200003)15:3<234::AID-GPS99>3.0.CO;2-G","article-title":"Diagnostic performance of two mental status tests in the older Chinese: influence of education and age on cut-off values","volume":"15","author":"Sahadevan","year":"2000","journal-title":"Int J Geriatr Psychiatry"},{"key":"key-10.1136\/jnnp-2016-313271-10","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/gps.1488","article-title":"Screening for dementia in the older Chinese with a single question test on progressive forgetfulness","volume":"21","author":"Chong","year":"2006","journal-title":"Int J Geriatr Psychiatry"},{"key":"key-10.1136\/jnnp-2016-313271-11","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1212\/WNL.0b013e3181c3fcb7","article-title":"Severity of CIND and MCI predict incidence of dementia in an ischemic stroke cohort","volume":"73","author":"Narasimhalu","year":"2009","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2016-313271-12","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1017\/S1041610215000976","article-title":"Association of neuropsychiatric symptoms and sub-syndromes with cognitive impairment in community-dwelling Asian elderly","volume":"27","author":"Xu","year":"2015","journal-title":"Int Psychogeriatr"},{"issue":"6","key":"key-10.1136\/jnnp-2016-313271-13","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1212\/WNL.48.5_Suppl_6.10S","article-title":"The Neuropsychiatric Inventory: assessing psychopathology in dementia patients","volume":"48","author":"Cummings","year":"1997","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2016-313271-14","doi-asserted-by":"crossref","first-page":"e297","DOI":"10.1097\/MD.0000000000000297","article-title":"Markers of cardiac dysfunction in cognitive impairment and dementia","volume":"94","author":"Hilal","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"key-10.1136\/jnnp-2016-313271-15","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1212\/WNL.43.9.1683","article-title":"Pathologic correlates of incidental MRI white matter signal hyperintensities","volume":"43","author":"Fazekas","year":"1993","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2016-313271-16","first-page":"471","volume-title":"Diagnostic and statistical manual of mental disorders American Psychiatric Association","author":"Association","year":"1994"},{"key":"key-10.1136\/jnnp-2016-313271-17","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1212\/WNL.0b013e3182452928","article-title":"Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study","volume":"78","author":"Poels","year":"2012","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2016-313271-18","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1136\/jnnp.2009.175372","article-title":"Microbleeds and post-stroke emotional lability","volume":"80","author":"Tang","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2016-313271-19","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1212\/WNL.46.1.130","article-title":"The spectrum of behavioral changes in Alzheimer's disease","volume":"46","author":"Mega","year":"1996","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2016-313271-20","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1093\/brain\/awv004","article-title":"Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network","volume":"138","author":"Ringman","year":"2015","journal-title":"Brain"},{"key":"key-10.1136\/jnnp-2016-313271-21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/arclin\/8.3.185","article-title":"The orbitomedial frontal syndrome","volume":"8","author":"Malloy","year":"1993","journal-title":"Arch Clin Neuropsychol"},{"key":"key-10.1136\/jnnp-2016-313271-22","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1001\/archneurol.2011.93","article-title":"Lobar distribution of cerebral microbleeds: the Rotterdam Scan Study","volume":"68","author":"Mesker","year":"2011","journal-title":"Arch Neurol"},{"key":"key-10.1136\/jnnp-2016-313271-23","doi-asserted-by":"crossref","first-page":"4825","DOI":"10.1007\/s00018-015-2044-6","article-title":"Neuronal correlates of depression","volume":"72","author":"Chaudhury","year":"2015","journal-title":"Cell Mol Life Sci"},{"key":"key-10.1136\/jnnp-2016-313271-24","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1007\/s11920-012-0322-7","article-title":"Where in the brain is depression?","volume":"14","author":"Pandya","year":"2012","journal-title":"Curr Psychiatry Rep"},{"key":"key-10.1136\/jnnp-2016-313271-25","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0022-3999(02)00428-2","article-title":"Frontal-subcortical neuronal circuits and clinical neuropsychiatry: an update","volume":"53","author":"Tekin","year":"2002","journal-title":"J Psychosom Res"},{"key":"key-10.1136\/jnnp-2016-313271-26","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1212\/01.wnl.0000307750.41970.d9","article-title":"Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study","volume":"70","author":"Vernooij","year":"2008","journal-title":"Neurology"},{"issue":"10","key":"key-10.1136\/jnnp-2016-313271-27","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1161\/STROKEAHA.110.595181","article-title":"Prevalence and risk factors of cerebral microbleeds: an update of the Rotterdam scan study","volume":"41","author":"Poels","year":"2010","journal-title":"Stroke"},{"key":"key-10.1136\/jnnp-2016-313271-28","doi-asserted-by":"crossref","DOI":"10.2174\/1567205012666151002123813","article-title":"Prevalence of cognitive impairment and dementia in Malays\u2014Epidemiology of Dementia in Singapore Study","author":"Hilal","year":"2015","journal-title":"Curr Alzheimer Res"}],"container-title":["Journal of Neurology, Neurosurgery &amp; Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp-2016-313271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T18:03:25Z","timestamp":1601057005000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnnp.bmj.com\/lookup\/doi\/10.1136\/jnnp-2016-313271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,3]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,12,15]]},"published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1136\/jnnp-2016-313271"],"URL":"https:\/\/doi.org\/10.1136\/jnnp-2016-313271","relation":{},"ISSN":["0022-3050","1468-330X"],"issn-type":[{"value":"0022-3050","type":"print"},{"value":"1468-330X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,3]]}}}