{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T10:40:15Z","timestamp":1784976015500,"version":"3.55.0"},"reference-count":52,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Neurol Neurosurg Psychiatry"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1136\/jnnp-2016-314337","type":"journal-article","created":{"date-parts":[[2017,5,14]],"date-time":"2017-05-14T00:10:33Z","timestamp":1494720633000},"page":"901-907","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["Structural MRI correlates of amyotrophic lateral sclerosis progression"],"prefix":"10.1136","volume":"88","author":[{"given":"Joe","family":"Senda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Atsuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohisa","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Epifanio","family":"Bagarinao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daichi","family":"Yokoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Riku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihito","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoichi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazuki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahisa","family":"Katsuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Naganawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Sobue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,5,13]]},"reference":[{"issue":"Suppl 1","key":"key-10.1136\/jnnp-2016-314337-1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3109\/21678421.2013.778548","article-title":"Deciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis","volume":"14","author":"Ravits","year":"2013","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"key-10.1136\/jnnp-2016-314337-2","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1212\/WNL.0b013e3181b6bbbd","article-title":"ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degeneration","volume":"73","author":"Ravits","year":"2009","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2016-314337-3","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.cortex.2011.02.004","article-title":"The anatomy of cognitive impairment in amyotrophic lateral sclerosis: more than frontal lobe dysfunction","volume":"48","author":"Tsermentseli","year":"2012","journal-title":"Cortex"},{"key":"key-10.1136\/jnnp-2016-314337-4","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1001\/jamaneurol.2013.5489","article-title":"Lower motor neuron involvement in TAR DNA-binding protein of 43 kDa-related frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"71","author":"Riku","year":"2014","journal-title":"JAMA Neurol"},{"key":"key-10.1136\/jnnp-2016-314337-5","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/jnen\/nlw053","article-title":"Marked involvement of the striatal efferent system in TAR DNA-binding protein 43\u2009kDa-related frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"75","author":"Riku","year":"2016","journal-title":"J Neuropathol Exp Neurol"},{"key":"key-10.1136\/jnnp-2016-314337-6","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1001\/archneurol.2008.558","article-title":"Clinical and pathological continuum of multisystem TDP-43 proteinopathies","volume":"66","author":"Geser","year":"2009","journal-title":"Arch Neurol"},{"key":"key-10.1136\/jnnp-2016-314337-7","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1212\/01.wnl.0000437313.80913.2c","article-title":"Basal ganglia involvement in amyotrophic lateral sclerosis","volume":"81","author":"Bede","year":"2013","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2016-314337-8","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1080\/21678421.2016.1211151","article-title":"Involvement of the caudate nucleus head and its networks in sporadic amyotrophic lateral sclerosis-frontotemporal dementia continuum","volume":"17","author":"Masuda","year":"2016","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"key-10.1136\/jnnp-2016-314337-9","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/mrm.1910360612","article-title":"Toward a quantitative assessment of diffusion anisotropy","volume":"36","author":"Pierpaoli","year":"1996","journal-title":"Magn Reson Med"},{"key":"key-10.1136\/jnnp-2016-314337-10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/nbm.1940080707","article-title":"Inferring microstructural features and the physiological state of tissues from diffusion-weighted images","volume":"8","author":"Basser","year":"1995","journal-title":"NMR Biomed"},{"key":"key-10.1136\/jnnp-2016-314337-11","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.3174\/ajnr.A2105","article-title":"Assessment of white matter tract damage in patients with amyotrophic lateral sclerosis: a diffusion tensor MR imaging tractography study","volume":"31","author":"Agosta","year":"2010","journal-title":"AJNR Am J Neuroradiol"},{"key":"key-10.1136\/jnnp-2016-314337-12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/17482968.2010.517850","article-title":"Progressive and widespread brain damage in ALS: MRI voxel-based morphometry and diffusion tensor imaging study","volume":"12","author":"Senda","year":"2011","journal-title":"Amyotroph Lateral Scler"},{"key":"key-10.1136\/jnnp-2016-314337-13","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jns.2011.05.025","article-title":"Behavioral changes in early ALS correlate with voxel-based morphometry and diffusion tensor imaging","volume":"307","author":"Tsujimoto","year":"2011","journal-title":"J Neurol Sci"},{"key":"key-10.1136\/jnnp-2016-314337-14","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3109\/21678421.2014.990036","article-title":"Factors affecting longitudinal functional decline and survival in amyotrophic lateral sclerosis patients","volume":"16","author":"Watanabe","year":"2015","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"key-10.1136\/jnnp-2016-314337-15","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1136\/jnnp-2013-306020","article-title":"Neck weakness is a potent prognostic factor in sporadic amyotrophic lateral sclerosis patients","volume":"84","author":"Nakamura","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2016-314337-16","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1136\/jnnp-2015-311541","article-title":"A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN","volume":"87","author":"Watanabe","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2016-314337-17","first-page":"e1","article-title":"Next-generation sequencing of 28 ALS-related genes in a Japanese ALS cohort","volume":"219","author":"Nakamura","year":"2016","journal-title":"Neurobiol Aging"},{"key":"key-10.1136\/jnnp-2016-314337-18","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2214\/ajr.149.2.351","article-title":"MR signal abnormalities at 1.5 T in Alzheimer\u2019s dementia and normal aging","volume":"149","author":"Fazekas","year":"1987","journal-title":"AJR Am J Roentgenol"},{"key":"key-10.1136\/jnnp-2016-314337-19","first-page":"679","article-title":"Sporadic and hereditary amyotrophic lateral sclerosis (ALS)","volume":"2015","author":"Ajroud-Driss","year":"1852","journal-title":"Biochim Biophys Acta"},{"key":"key-10.1136\/jnnp-2016-314337-20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"key-10.1136\/jnnp-2016-314337-21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"key-10.1136\/jnnp-2016-314337-22","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1212\/WNL.55.11.1621","article-title":"The FAB: a Frontal Assessment Battery at bedside","volume":"55","author":"Dubois","year":"2000","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2016-314337-23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-510X(99)00210-5","article-title":"The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III)","volume":"169","author":"Cedarbaum","year":"1999","journal-title":"J Neurol Sci"},{"key":"key-10.1136\/jnnp-2016-314337-24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jns.2008.07.016","article-title":"ALSFRS-R score and its ratio: a useful predictor for ALS-progression","volume":"275","author":"Kollewe","year":"2008","journal-title":"J Neurol Sci"},{"key":"key-10.1136\/jnnp-2016-314337-25","first-page":"1129","article-title":"Age of onset differentially influences the progression of regional dysfunction in sporadic amyotrophic lateral sclerosis","volume":"263","author":"Yokoi","year":"2016","journal-title":"J\u00a0Neurol"},{"key":"key-10.1136\/jnnp-2016-314337-26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1212\/01.wnl.0000194316.91908.8a","article-title":"Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS","volume":"66","author":"Kimura","year":"2006","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2016-314337-27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/hbm.460020402","article-title":"Statistical parametric maps in functional imaging: a general linear approach","volume":"2","author":"Friston","year":"1994","journal-title":"Hum Brain Mapp"},{"key":"key-10.1136\/jnnp-2016-314337-28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","article-title":"A fast diffeomorphic image registration algorithm","volume":"38","author":"Ashburner","year":"2007","journal-title":"Neuroimage"},{"key":"key-10.1136\/jnnp-2016-314337-29","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"Neuroimage"},{"key":"key-10.1136\/jnnp-2016-314337-30","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuroimage.2008.03.061","article-title":"Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference","volume":"44","author":"Smith","year":"2009","journal-title":"Neuroimage"},{"key":"key-10.1136\/jnnp-2016-314337-31","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ana.23937","article-title":"Stages of pTDP-43 pathology in amyotrophic lateral sclerosis","volume":"74","author":"Brettschneider","year":"2013","journal-title":"Ann Neurol"},{"key":"key-10.1136\/jnnp-2016-314337-32","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1093\/brain\/awu090","article-title":"Diffusion tensor imaging analysis of sequential spreading of disease in amyotrophic lateral sclerosis confirms patterns of TDP-43 pathology","volume":"137","author":"Kassubek","year":"2014","journal-title":"Brain"},{"key":"key-10.1136\/jnnp-2016-314337-33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2377-6-17","article-title":"Widespread sensorimotor and frontal cortical atrophy in Amyotrophic Lateral Sclerosis","volume":"6","author":"Grosskreutz","year":"2006","journal-title":"BMC Neurol"},{"key":"key-10.1136\/jnnp-2016-314337-34","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.nicl.2012.12.003","article-title":"Structural imaging differences and longitudinal changes in primary lateral sclerosis and amyotrophic lateral sclerosis","volume":"2","author":"Kwan","year":"2012","journal-title":"Neuroimage Clin"},{"key":"key-10.1136\/jnnp-2016-314337-35","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1136\/jnnp.2006.101758","article-title":"Diffusion tensor imaging and voxel based morphometry study in amyotrophic lateral sclerosis: relationships with motor disability","volume":"78","author":"Thivard","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2016-314337-36","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/hbm.20527","article-title":"Investigation of white matter pathology in ALS and PLS using tract-based spatial statistics","volume":"30","author":"Ciccarelli","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"key-10.1136\/jnnp-2016-314337-37","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1001\/archneurol.2012.1122","article-title":"Fractional anisotropy in the posterior limb of the internal capsule and prognosis in amyotrophic lateral sclerosis","volume":"69","author":"Menke","year":"2012","journal-title":"Arch Neurol"},{"key":"key-10.1136\/jnnp-2016-314337-38","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1212\/WNL.0000000000001642","article-title":"Neurofilament light chain: a prognostic biomarker in amyotrophic lateral sclerosis","volume":"84","author":"Lu","year":"2015","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2016-314337-39","first-page":"1505","article-title":"Biomarker-based predictive models for prognosis in amyotrophic lateral sclerosis","volume":"70","author":"Su","year":"2013","journal-title":"JAMA Neurol"},{"key":"key-10.1136\/jnnp-2016-314337-40","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/1471-2202-13-141","article-title":"Longitudinal diffusion tensor imaging in amyotrophic lateral sclerosis","volume":"13","author":"Keil","year":"2012","journal-title":"BMC Neurosci"},{"key":"key-10.1136\/jnnp-2016-314337-41","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1093\/brain\/awu162","article-title":"Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis","volume":"137","author":"Menke","year":"2014","journal-title":"Brain"},{"key":"key-10.1136\/jnnp-2016-314337-42","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.nicl.2016.03.011","article-title":"Structural and diffusion imaging versus clinical assessment to monitor amyotrophic lateral sclerosis","volume":"11","author":"Cardenas-Blanco","year":"2016","journal-title":"Neuroimage Clin"},{"key":"key-10.1136\/jnnp-2016-314337-43","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.neurobiolaging.2014.09.002","article-title":"Subcortical structures in amyotrophic lateral sclerosis","volume":"36","author":"Westeneng","year":"2015","journal-title":"Neurobiol Aging"},{"key":"key-10.1136\/jnnp-2016-314337-44","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1007\/s00415-014-7434-4","article-title":"Central white matter degeneration in bulbar- and limb-onset amyotrophic lateral sclerosis","volume":"261","author":"Cardenas-Blanco","year":"2014","journal-title":"J Neurol"},{"key":"key-10.1136\/jnnp-2016-314337-45","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1552-6569.2011.00679.x","article-title":"Diffusion tensor imaging of basal ganglia and thalamus in amyotrophic lateral sclerosis","volume":"23","author":"Sharma","year":"2013","journal-title":"J Neuroimaging"},{"key":"key-10.1136\/jnnp-2016-314337-46","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1136\/jnnp-2015-310998","article-title":"Rate of disease progression: a prognostic biomarker in ALS","volume":"87","author":"Labra","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2016-314337-47","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1007\/s00415-014-7564-8","article-title":"Prognostic factors for the course of functional status of patients with ALS: a systematic review","volume":"262","author":"Creemers","year":"2015","journal-title":"J Neurol"},{"key":"key-10.1136\/jnnp-2016-314337-48","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3109\/21678421.2015.1051989","article-title":"Mind the gap: the mismatch between clinical and imaging metrics in ALS","volume":"16","author":"Verstraete","year":"2015","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"key-10.1136\/jnnp-2016-314337-49","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2015.0060","article-title":"Vertebrate brains and evolutionary connectomics: on the origins of the mammalian \u2019neocortex'","volume":"370","author":"Karten","year":"2015","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"key-10.1136\/jnnp-2016-314337-50","doi-asserted-by":"crossref","first-page":"E3159","DOI":"10.1073\/pnas.1605658113","article-title":"Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits","volume":"113","author":"Kondabolu","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.1136\/jnnp-2016-314337-51","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1212\/WNL.0b013e318214359f","article-title":"Executive dysfunction is a negative prognostic indicator in patients with ALS without dementia","volume":"76","author":"Elamin","year":"2011","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2016-314337-52","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S1474-4422(11)70049-7","article-title":"Towards a neuroimaging biomarker for amyotrophic lateral sclerosis","volume":"10","author":"Turner","year":"2011","journal-title":"Lancet Neurol"}],"container-title":["Journal of Neurology, Neurosurgery & Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp-2016-314337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T18:03:56Z","timestamp":1601057036000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnnp.bmj.com\/lookup\/doi\/10.1136\/jnnp-2016-314337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,13]]},"references-count":52,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,10,9]]},"published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1136\/jnnp-2016-314337"],"URL":"https:\/\/doi.org\/10.1136\/jnnp-2016-314337","relation":{},"ISSN":["0022-3050","1468-330X"],"issn-type":[{"value":"0022-3050","type":"print"},{"value":"1468-330X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,13]]}}}