{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T02:52:36Z","timestamp":1789267956676,"version":"build-2803163510"},"reference-count":33,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Neurol Neurosurg Psychiatry"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1136\/jnnp-2016-315071","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:45:19Z","timestamp":1489538719000},"page":"550-556","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Exploring the fitness hypothesis in ALS: a population-based case-control study of parental cause of death and lifespan"],"prefix":"10.1136","volume":"88","author":[{"given":"Anne E","family":"Visser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinie","family":"Seelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Hulsbergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris","family":"de Graaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneke J","family":"van der Kooi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Raaphorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H","family":"Veldink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard H","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"key-10.1136\/jnnp-2016-315071-1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrneurol.2011.153","article-title":"Clinical diagnosis and management of amyotrophic lateral sclerosis","volume":"7","author":"Hardiman","year":"2011","journal-title":"Nat Rev Neurol"},{"key":"key-10.1136\/jnnp-2016-315071-2","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrneurol.2013.203","article-title":"The epidemiology of ALS: a conspiracy of genes, environment and time","volume":"9","author":"Al-Chalabi","year":"2013","journal-title":"Nat Rev Neurol"},{"key":"key-10.1136\/jnnp-2016-315071-3","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1136\/jnnp-2012-304724","article-title":"Lifetime physical activity and the risk of amyotrophic lateral sclerosis","volume":"84","author":"Huisman","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2016-315071-4","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1136\/jnnp-2013-304935","article-title":"Increased premorbid physical activity and amyotrophic lateral sclerosis: born to run rather than run to death, or a seductive myth?","volume":"84","author":"Turner","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2016-315071-5","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/jnnp.2010.218982","article-title":"Physical fitness, but not muscle strength, is a risk factor for death in amyotrophic lateral sclerosis at an early age","volume":"83","author":"Mattsson","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2016-315071-6","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/ene.12015","article-title":"Prevalence and prognostic impact of comorbidities in amyotrophic lateral sclerosis","volume":"20","author":"K\u00f6rner","year":"2013","journal-title":"Eur J Neurol"},{"key":"key-10.1136\/jnnp-2016-315071-7","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1136\/jnnp-2011-301161","article-title":"Cardiovascular fitness as a risk factor for amyotrophic lateral sclerosis: indirect evidence from record linkage study","volume":"83","author":"Turner","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2016-315071-8","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1136\/jnnp.2011.244939","article-title":"Population based epidemiology of amyotrophic lateral sclerosis using capture-recapture methodology","volume":"82","author":"Huisman","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2016-315071-9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"World federation of neurology research group on motor neuron diseases. el escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"key-10.1136\/jnnp-2016-315071-10","unstructured":"Centers for disease control and prevention. Falls among older adults. http:\/\/www.cdc.gov\/homeandrecreationalsafety\/falls\/adultfalls.html (accessed Sep 6 2016)."},{"key":"key-10.1136\/jnnp-2016-315071-11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"key-10.1136\/jnnp-2016-315071-12","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1212\/WNL.0b013e3182661d14","article-title":"Hexanucleotide repeat expansions in C9ORF72 in the spectrum of motor neuron diseases","volume":"79","author":"van Rheenen","year":"2012","journal-title":"Neurology"},{"issue":"Pt 9","key":"key-10.1136\/jnnp-2016-315071-13","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1093\/brain\/aws144","article-title":"Young-onset amyotrophic lateral sclerosis: historical and other observations","volume":"135","author":"Turner","year":"2012","journal-title":"Brain"},{"key":"key-10.1136\/jnnp-2016-315071-14","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1007\/s13524-014-0303-z","article-title":"The schooling of offspring and the survival of parents","volume":"51","author":"Friedman","year":"2014","journal-title":"Demography"},{"key":"key-10.1136\/jnnp-2016-315071-15","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.jacc.2016.05.072","article-title":"Longer-Lived parents and cardiovascular outcomes","volume":"68","author":"Atkins","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"key-10.1136\/jnnp-2016-315071-16","doi-asserted-by":"crossref","first-page":"688","DOI":"10.15252\/emmm.201506174","article-title":"The impact of genome-wide association studies on\u00a0the pathophysiology and therapy of cardiovascular disease","volume":"8","author":"Kessler","year":"2016","journal-title":"EMBO Mol Med"},{"key":"key-10.1136\/jnnp-2016-315071-17","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1001\/jamaneurol.2014.3367","article-title":"Angiotensin-converting enzyme inhibitors and amyotrophic lateral sclerosis risk: a total population-based case-control study","volume":"72","author":"Lin","year":"2015","journal-title":"JAMA Neurol"},{"key":"key-10.1136\/jnnp-2016-315071-18","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1212\/WNL.0b013e318231530b","article-title":"Family history of neurodegenerative and vascular diseases in ALS: a population-based study","volume":"77","author":"Huisman","year":"2011","journal-title":"Neurology"},{"key":"key-10.1136\/jnnp-2016-315071-19","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1161\/CIRCULATIONAHA.108.816694","article-title":"Predicting the 30-year risk of cardiovascular disease: the framingham heart study","volume":"119","author":"Pencina","year":"2009","journal-title":"Circulation"},{"key":"key-10.1136\/jnnp-2016-315071-20","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1111\/ene.12632","article-title":"Association between diabetes and amyotrophic lateral sclerosis in Sweden","volume":"22","author":"Mariosa","year":"2015","journal-title":"Eur J Neurol"},{"key":"key-10.1136\/jnnp-2016-315071-21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3109\/21678421.2012.735240","article-title":"Premorbid body mass index and risk of amyotrophic lateral sclerosis","volume":"14","author":"O'Reilly","year":"2013","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"key-10.1136\/jnnp-2016-315071-22","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1136\/jnnp.2010.236752","article-title":"Beneficial vascular risk profile is associated with amyotrophic lateral sclerosis","volume":"82","author":"Sutedja","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2016-315071-23","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1007\/s00415-014-7445-1","article-title":"Prior medical conditions and the risk of amyotrophic lateral sclerosis","volume":"261","author":"Seelen","year":"2014","journal-title":"J Neurol"},{"key":"key-10.1136\/jnnp-2016-315071-24","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1002\/ijc.28795","article-title":"The risk of amyotrophic lateral sclerosis after cancer in U.S. elderly adults: a population-based prospective study","volume":"135","author":"Freedman","year":"2014","journal-title":"Int J Cancer"},{"key":"key-10.1136\/jnnp-2016-315071-25","doi-asserted-by":"crossref","first-page":"00","DOI":"10.1371\/journal.pone.0103572","article-title":"Is the risk of motor neuron disease increased or decreased after cancer? an australian case-control study","volume":"9","author":"Stoyanov","year":"2014","journal-title":"PLoS One"},{"issue":"5-6","key":"key-10.1136\/jnnp-2016-315071-26","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3109\/21678421.2013.775309","article-title":"Amyotrophic lateral sclerosis and cancer: a register-based study in Sweden","volume":"14","author":"Fang","year":"2013","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"key-10.1136\/jnnp-2016-315071-27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1136\/jnnp.2009.175463","article-title":"Cancer in patients with motor neuron disease, multiple sclerosis and Parkinson's disease: record linkage studies","volume":"81","author":"Fois","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.1136\/jnnp-2016-315071-28","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1007\/s00415-009-5100-z","article-title":"Hypermetabolism in ALS patients: an early and persistent phenomenon","volume":"256","author":"Bouteloup","year":"2009","journal-title":"J Neurol"},{"key":"key-10.1136\/jnnp-2016-315071-29","doi-asserted-by":"crossref","first-page":"11159","DOI":"10.1073\/pnas.0402026101","article-title":"Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: benefit of a high-energy diet in a transgenic mouse model","volume":"101","author":"Dupuis","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.1136\/jnnp-2016-315071-30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1474-4422(10)70224-6","article-title":"Energy metabolism in amyotrophic lateral sclerosis","volume":"10","author":"Dupuis","year":"2011","journal-title":"Lancet Neurol"},{"key":"key-10.1136\/jnnp-2016-315071-31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/17482960802295192","article-title":"High metabolic level in patients with familial amyotrophic lateral sclerosis","volume":"10","author":"Funalot","year":"2009","journal-title":"Amyotroph Lateral Scler"},{"key":"key-10.1136\/jnnp-2016-315071-32","doi-asserted-by":"crossref","first-page":"16320","DOI":"10.1073\/pnas.1002176107","article-title":"Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism","volume":"107","author":"Chiang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.1136\/jnnp-2016-315071-33","doi-asserted-by":"crossref","first-page":"00","DOI":"10.1371\/journal.pone.0071793","article-title":"TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis","volume":"8","author":"Stallings","year":"2013","journal-title":"PLoS One"}],"container-title":["Journal of Neurology, Neurosurgery & Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp-2016-315071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T18:05:56Z","timestamp":1601057156000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnnp.bmj.com\/lookup\/doi\/10.1136\/jnnp-2016-315071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,14]]},"references-count":33,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,8,17]]},"published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1136\/jnnp-2016-315071"],"URL":"https:\/\/doi.org\/10.1136\/jnnp-2016-315071","relation":{},"ISSN":["0022-3050","1468-330X"],"issn-type":[{"value":"0022-3050","type":"print"},{"value":"1468-330X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,14]]}}}