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Unlike MS, the course is usually relapsing, and it is unclear, if progressive neurodegeneration contributes to disability. Therefore, we aimed to investigate if progressive retinal neuroaxonal damage occurs in aquaporin4-antibody-seropositive NMOSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Out of 157 patients with NMOSD screened, 94 eyes of 51 patients without optic neuritis\u00a0(ON) during follow-up (F\/U) and 56 eyes of 28 age-matched and sex-matched healthy controls (HC) were included (median F\/U 2.3 years). The NMOSD cohort included 60 eyes without (Eye\n                      <jats:sup>ON<\/jats:sup>\n                      <jats:sup>\u2212<\/jats:sup>\n                      ) and 34 eyes with a history of ON prior to enrolment (Eye\n                      <jats:sup>ON+<\/jats:sup>\n                      ). Peripapillary retinal nerve fibre layer thickness (pRNFL), fovea thickness (FT), volumes of the combined ganglion cell and inner plexiform layer (GCIP) and the inner nuclear layer (INL) and total macular volume (TMV) were acquired by optical coherence tomography (OCT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, GCIP, FT and TMV were reduced in Eye\n                      <jats:sup>ON+<\/jats:sup>\n                      (GCIP p&lt;2e\n                      <jats:sup>\u221216<\/jats:sup>\n                      ; FT p=3.7e\n                      <jats:sup>\u22124<\/jats:sup>\n                      ; TMV p=3.7e\n                      <jats:sup>\u221212<\/jats:sup>\n                      ) and\u00a0in Eye\n                      <jats:sup>ON<\/jats:sup>\n                      <jats:sup>\u2212<\/jats:sup>\n                      \u00a0(GCIP p=0.002; FT p=0.040; TMV p=6.1e\n                      <jats:sup>\u22126<\/jats:sup>\n                      ) compared with HC. Longitudinally, we observed GCIP thinning in Eye\n                      <jats:sup>ON\u2212<\/jats:sup>\n                      (p=0.044) but not in Eye\n                      <jats:sup>ON+<\/jats:sup>\n                      . Seven patients had attacks during F\/U; they presented pRNFL thickening compared with\u00a0patients without attacks (p=0.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study clearly shows GCIP loss independent of ON attacks in aquaporin4-antibody-seropositive NMOSD. Potential explanations for progressive GCIP thinning include primary retinopathy, drug-induced neurodegeneration and retrograde neuroaxonal degeneration from lesions or optic neuropathy. pRNFL thickening in the patients presenting with attacks during F\/U might be indicative of pRNFL susceptibility to inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jnnp-2018-318382","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T12:25:37Z","timestamp":1529411137000},"page":"1259-1265","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":109,"title":["Retinal ganglion cell loss in neuromyelitis optica: a longitudinal study"],"prefix":"10.1136","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4906-5983","authenticated-orcid":false,"given":"Frederike C","family":"Oertel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Havla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Roca-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Lizak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedamirhosein","family":"Motamedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Borisow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen B","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Bellmann-Strobl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Albrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klemens","family":"Ruprecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Jarius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Palace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Isabel","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Kuempfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedemann","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander U","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,6,19]]},"reference":[{"key":"2020050722284944000_89.12.1259.1","doi-asserted-by":"crossref","unstructured":"Jarius S , Paul F , Fechner K , et al . 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