{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:25:02Z","timestamp":1792880702294,"version":"4.5.0"},"reference-count":40,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Neurol Neurosurg Psychiatry"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Frontotemporal dementia (FTD) is a heterogeneous clinical syndrome linked to diverse types of underlying neuropathology. Diagnosis is mainly based on clinical presentation and accurate prediction of underlying neuropathology remains difficult.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We present a large cohort of patients with FTD spectrum diseases (n=84). All patients were thoroughly characterised by cerebrospinal fluid (CSF) Alzheimer\u2019s disease (AD) biomarkers, neuroimaging, neuropsychological testing and standardised apraxia screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A potential AD pathology was found in 43% of patients with FTD. CSF AD biomarker levels positively correlated with AD-typical apraxia scores in patients with FTD. The discriminative power of apraxia test results indicative of AD pathology was high (sensitivity: 90%, specificity: 66%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Apraxia is common in neurodegenerative dementias but under-represented in clinical workup and diagnostic criteria. Standardised apraxia screening may serve as bedside test to objectify an AD-typical apraxia profile as an early and robust sign of AD pathology in patients with FTD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jnnp-2018-318470","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T12:19:12Z","timestamp":1539173952000},"page":"562-569","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Apraxia screening predicts Alzheimer pathology in frontotemporal dementia"],"prefix":"10.1136","volume":"90","author":[{"given":"Matthias","family":"Pawlowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Joksch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Wiendl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven G","family":"Meuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Duning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Johnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"key":"2023011306100788000_90.5.562.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00461-4"},{"key":"2023011306100788000_90.5.562.2","doi-asserted-by":"publisher","DOI":"10.2174\/1745017901309010088"},{"key":"2023011306100788000_90.5.562.3","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"2023011306100788000_90.5.562.4","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr179"},{"key":"2023011306100788000_90.5.562.5","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0460-5"},{"key":"2023011306100788000_90.5.562.6","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.212225"},{"key":"2023011306100788000_90.5.562.7","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304644"},{"key":"2023011306100788000_90.5.562.8","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh598"},{"key":"2023011306100788000_90.5.562.9","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20700"},{"key":"2023011306100788000_90.5.562.10","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20873"},{"key":"2023011306100788000_90.5.562.11","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr031"},{"key":"2023011306100788000_90.5.562.12","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-313775"},{"key":"2023011306100788000_90.5.562.13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3233\/JAD-121969","article-title":"Overlap between frontotemporal dementia and Alzheimer's disease: cerebrospinal fluid pattern and neuroimaging study","volume":"36","author":"Padovani","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"2023011306100788000_90.5.562.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"2023011306100788000_90.5.562.15","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-308773"},{"key":"2023011306100788000_90.5.562.16","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1212\/01.CON.0000368262.53662.08","article-title":"Apraxia","volume":"16","author":"Heilman","year":"2010","journal-title":"Continuum"},{"key":"2023011306100788000_90.5.562.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2008.07.014"},{"key":"2023011306100788000_90.5.562.18","unstructured":"Weiss PH , Kalbe E , Kessler J . 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