{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:10:39Z","timestamp":1775261439020,"version":"3.50.1"},"reference-count":15,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Neurol Neurosurg Psychiatry"],"published-print":{"date-parts":[[2019,2]]},"abstract":"\n Objective<\/jats:title>\n To describe an expanded teased nerve fibre classification in disease association.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We reviewed four newly proposed teased nerve fibre types (\n Types J\u2013M<\/jats:italic>\n ): Type J, rope-like fibres; K, fibril-like clumps of osmium positivity; L, cellular debris along and within nerve fibres; M, circular axonal inclusions surrounded by thin myelin. Different clinical pathological entities were studied for these fibre types including chronic inflammatory demyelinating polyradiculoneuropathy (CIDP: N=20); amyloid polyneuropathy (N=20); intraneural B-cell lymphoma (N=20) or adult-onset polyglucosan body disease (APBD: N=6) in comparison with 112 disease controls. Student\u2019s t-test was used to test significance of association between the identified fibre types and the specific clinical diagnosis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Each fibre type significantly associated (p<0.001) with particular disease categories:\n Type J<\/jats:italic>\n , 60% of CIDP cases;\n Type K<\/jats:italic>\n , 75% of amyloid cases;\n Type L<\/jats:italic>\n , 75% of intraneural lymphoma cases;\n Type M<\/jats:italic>\n , 100% of APBD cases. Rarely were these fibres found in the other disease control cases \u22643% of cases. In three cases, the teased fibre findings were so striking additional paraffin nerve preparations were made to make the pathological diagnosis when initial paraffin sections were non-diagnostic.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Teased nerve fibre\n Types J\u2013M<\/jats:italic>\n associate with commonly seen pathological diagnosis and are helpful in the consideration of specific neuropathy diagnoses.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/jnnp-2018-319077","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T12:25:29Z","timestamp":1541075129000},"page":"138-140","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Expanded teased nerve fibre pathological conditions in disease association"],"prefix":"10.1136","volume":"90","author":[{"given":"Min","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenjing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janean K","family":"Engelstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"James Dyck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J","family":"Dyck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,11,1]]},"reference":[{"key":"2020050722330880000_90.2.138.1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1600-0404.2011.01546.x","article-title":"Nerve biopsy\u2014some comments on procedures and indications","volume":"191","author":"Mellgren","year":"2011","journal-title":"Acta Neurol Scand Suppl"},{"key":"2020050722330880000_90.2.138.2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0025-6196(26)01576-4","article-title":"Histologic and teased-fiber measurements of sural nerve in disorders of lower motor and primary sensory neurons","volume":"43","author":"Dyck","year":"1968","journal-title":"Mayo Clin Proc"},{"key":"2020050722330880000_90.2.138.3","doi-asserted-by":"crossref","unstructured":"Dyck PJ P , James D , Engelstad J . Pathological alterations of nerve . 4th edn. Elsevier: Peripheral Neuropathy, 2005: 733\u2013829.","DOI":"10.1016\/B978-0-7216-9491-7.50035-1"},{"key":"2020050722330880000_90.2.138.4","first-page":"571","article-title":"Morphometric evaluation of peripheral nerve","volume":"36","author":"Dyck","year":"1974","journal-title":"Electoencephalogr Clin Neurophysiol"},{"key":"2020050722330880000_90.2.138.5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.25.8.781"},{"key":"2020050722330880000_90.2.138.6","doi-asserted-by":"crossref","unstructured":"Takahashi M , Koike H , Ikeda S , et al . Distinct pathogenesis in nonsystemic vasculitic neuropathy and microscopic polyangiitis. Neurol Neuroimmunol Neuroinflamm 2017;4:e407.doi:10.1212\/NXI.0000000000000407","DOI":"10.1212\/NXI.0000000000000407"},{"key":"2020050722330880000_90.2.138.7","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.4.483"},{"key":"2020050722330880000_90.2.138.8","first-page":"233","article-title":"Classification of teased nerve fibers for multicenter clinical trials","volume":"4","author":"Kalichman","year":"1999","journal-title":"J Peripher Nerv Syst"},{"key":"2020050722330880000_90.2.138.9","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.5.617"},{"key":"2020050722330880000_90.2.138.10","doi-asserted-by":"crossref","unstructured":"Kyle A , Kelly JJ , Dyck PJ . Amyloidosis and neuropathy. In: Peripheral neuropathy. 4th edn. 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