{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:40:20Z","timestamp":1792798820446,"version":"4.5.0"},"reference-count":60,"publisher":"BMJ","issue":"10","funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["1085272"],"award-info":[{"award-number":["1085272"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["APP1104194"],"award-info":[{"award-number":["APP1104194"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Veterans Affairs Rehabilitation Research & Development Service","award":["B6364-L"],"award-info":[{"award-number":["B6364-L"]}],"id":[{"id":"https:\/\/ror.org\/008qp6e21","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Veterans Affairs Rehabilitation Research & Development Service","award":["C2238-P"],"award-info":[{"award-number":["C2238-P"]}],"id":[{"id":"https:\/\/ror.org\/008qp6e21","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Veterans Affairs Rehabilitation Research & Development Service","award":["IK1 RX002629"],"award-info":[{"award-number":["IK1 RX002629"]}],"id":[{"id":"https:\/\/ror.org\/008qp6e21","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"crossref","award":["FT120100608"],"award-info":[{"award-number":["FT120100608"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"crossref","award":["RP-2015-06-012"],"award-info":[{"award-number":["RP-2015-06-012"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institutes of Health\/ National Institute on Deafness and Other Communication Disorders","award":["P50 DC014664"],"award-info":[{"award-number":["P50 DC014664"]}],"id":[{"id":"https:\/\/ror.org\/04mhx6838","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Neurol Neurosurg Psychiatry"],"accepted":{"date-parts":[[2019,4,10]]},"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>Given the profound impact of language impairment after stroke (aphasia), neuroplasticity research is garnering considerable attention as means for eventually improving aphasia treatments and how they are delivered. Functional and structural neuroimaging studies indicate that aphasia treatments can recruit both residual and new neural mechanisms to improve language function and that neuroimaging modalities may hold promise in predicting treatment outcome. In relatively small clinical trials, both non-invasive brain stimulation and behavioural manipulations targeting activation or suppression of specific cortices can improve aphasia treatment outcomes. Recent language interventions that employ principles consistent with inducing neuroplasticity also are showing improved performance for both trained and novel items and contexts. While knowledge is rapidly accumulating, larger trials emphasising how to select optimal paradigms for individualised aphasia treatment are needed. Finally, a model of how to incorporate the growing knowledge into clinical practice could help to focus future research.<\/jats:p>","DOI":"10.1136\/jnnp-2018-319649","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T09:41:24Z","timestamp":1557135684000},"page":"1147-1155","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":106,"title":["Neuroplasticity and aphasia treatments: new approaches for an old problem"],"prefix":"10.1136","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3453-1374","authenticated-orcid":false,"given":"Bruce","family":"Crosson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy D","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Copland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Fridriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa C","family":"Krishnamurthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Meinzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia M","family":"Raymer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatagiri","family":"Krishnamurthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander P","family":"Leff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,5,4]]},"reference":[{"key":"2024111107500838000_90.10.1147.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2017.12.019"},{"key":"2024111107500838000_90.10.1147.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.004"},{"key":"2024111107500838000_90.10.1147.3","doi-asserted-by":"crossref","unstructured":"Menke R , Meinzer M , Kugel H , et al . Imaging short- and long-term training success in chronic aphasia. BMC Neuroscience 2009;10.doi:10.1186\/1471-2202-10-118","DOI":"10.1186\/1471-2202-10-118"},{"key":"2024111107500838000_90.10.1147.4","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003192"},{"key":"2024111107500838000_90.10.1147.5","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.cortex.2016.11.007","article-title":"Left inferior frontal gyrus mediates morphosyntax: Erp evidence from verb processing in left-hemisphere damaged patients","volume":"86","author":"Regel","year":"2017","journal-title":"Cortex"},{"key":"2024111107500838000_90.10.1147.6","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1016\/j.cortex.2013.02.003","article-title":"Training verb argument structure production in agrammatic aphasia: behavioral and neural recovery patterns","volume":"49","author":"Thompson","year":"2013","journal-title":"Cortex"},{"key":"2024111107500838000_90.10.1147.7","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv022"},{"key":"2024111107500838000_90.10.1147.8","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx234"},{"key":"2024111107500838000_90.10.1147.9","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt289"},{"key":"2024111107500838000_90.10.1147.10","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1212\/WNL.0000000000002537","article-title":"Network dysfunction predicts speech production after left hemisphere stroke","volume":"86","author":"Geranmayeh","year":"2016","journal-title":"Neurology"},{"key":"2024111107500838000_90.10.1147.11","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1089\/brain.2016.0437","article-title":"Increased modularity of resting state networks supports improved narrative production in aphasia recovery","volume":"6","author":"Duncan","year":"2016","journal-title":"Brain Connectivity"},{"key":"2024111107500838000_90.10.1147.12","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s11682-017-9771-2","article-title":"Changes in dynamic resting state network connectivity following aphasia therapy","volume":"12","author":"Duncan","year":"2018","journal-title":"Brain Imaging Behav"},{"key":"2024111107500838000_90.10.1147.13","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-314621"},{"key":"2024111107500838000_90.10.1147.14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bandl.2015.09.002","article-title":"Changes in functional connectivity related to direct training and generalization effects of a word finding treatment in chronic aphasia","volume":"150","author":"Sandberg","year":"2015","journal-title":"Brain and Language"},{"key":"2024111107500838000_90.10.1147.15","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1007\/s11682-016-9635-1","article-title":"Right sensory-motor functional networks subserve action observation therapy in aphasia","volume":"11","author":"Gili","year":"2017","journal-title":"Brain Imaging Behav"},{"key":"2024111107500838000_90.10.1147.16","first-page":"103","article-title":"Changes in white matter integrity follow excitatory rTMS treatment of post-stroke aphasia","volume":"30","author":"Allendorfer","year":"2012","journal-title":"Restor Neurol Neurosci"},{"key":"2024111107500838000_90.10.1147.17","doi-asserted-by":"publisher","DOI":"10.1177\/1545968313508654"},{"key":"2024111107500838000_90.10.1147.18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bandl.2014.03.011","article-title":"Intensive therapy induces contralateral white matter changes in chronic stroke patients with Broca's aphasia","volume":"136","author":"Wan","year":"2014","journal-title":"Brain Lang"},{"key":"2024111107500838000_90.10.1147.19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/ana.24983","article-title":"Structural plasticity of the ventral stream and aphasia recovery","volume":"82","author":"McKinnon","year":"2017","journal-title":"Ann Neurol"},{"key":"2024111107500838000_90.10.1147.20","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4714"},{"key":"2024111107500838000_90.10.1147.21","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx086"},{"key":"2024111107500838000_90.10.1147.22","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7407241"},{"key":"2024111107500838000_90.10.1147.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.12.057"},{"key":"2024111107500838000_90.10.1147.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2013.12.004"},{"key":"2024111107500838000_90.10.1147.25","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cortex.2015.04.013","article-title":"Speech entrainment compensates for Broca's area damage","volume":"69","author":"Fridriksson","year":"2015","journal-title":"Cortex"},{"key":"2024111107500838000_90.10.1147.26","doi-asserted-by":"publisher","DOI":"10.1177\/1545968315593808"},{"key":"2024111107500838000_90.10.1147.27","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000574"},{"key":"2024111107500838000_90.10.1147.28","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1016\/j.apmr.2015.06.017","article-title":"Add-on effects of repetitive transcranial magnetic stimulation on Subacute aphasia therapy: enhanced improvement of functional communication and basic linguistic skills. A randomized controlled study","volume":"96","author":"Rubi-Fessen","year":"2015","journal-title":"Arch Phys Med Rehabil"},{"key":"2024111107500838000_90.10.1147.29","doi-asserted-by":"publisher","DOI":"10.1177\/1545968314521009"},{"key":"2024111107500838000_90.10.1147.30","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12332"},{"key":"2024111107500838000_90.10.1147.31","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww002"},{"key":"2024111107500838000_90.10.1147.32","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1002\/hbm.23469","article-title":"Transcranial direct current stimulation effects on neural processing in post-stroke aphasia","volume":"38","author":"Darkow","year":"2017","journal-title":"Human Brain Mapping"},{"key":"2024111107500838000_90.10.1147.33","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1001\/jamaneurol.2018.2287","article-title":"Transcranial direct current stimulation vs sham stimulation to treat aphasia after stroke","volume":"75","author":"Fridriksson","year":"2018","journal-title":"JAMA Neurol"},{"key":"2024111107500838000_90.10.1147.34","doi-asserted-by":"crossref","unstructured":"Fridriksson J , Basilakos A , Stark BC , et al . Transcranial direct current stimulation to treat aphasia: longitudinal analysis of a randomized controlled trial. Brain Stimul 2018. epub ahead of print;1-6.","DOI":"10.1016\/j.brs.2018.09.016"},{"key":"2024111107500838000_90.10.1147.35","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6808293"},{"key":"2024111107500838000_90.10.1147.36","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3233\/NRE-141199","article-title":"Feasibility of using high-definition transcranial direct current stimulation (HD-tDCS) to enhance treatment outcomes in persons with aphasia","volume":"36","author":"Richardson","year":"2015","journal-title":"NeuroRehabilitation"},{"key":"2024111107500838000_90.10.1147.37","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/WNN.0000000000000141","article-title":"Functional reorganization of right prefrontal cortex underlies sustained naming improvements in chronic aphasia via repetitive transcranial magnetic stimulation","volume":"30","author":"Harvey","year":"2017","journal-title":"Cogn Behav Neurol"},{"key":"2024111107500838000_90.10.1147.38","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1044\/2015_AJSLP-14-0018","article-title":"Constraint-induced aphasia therapy versus intensive semantic treatment in fluent aphasia","volume":"24","author":"Wilssens","year":"2015","journal-title":"Am J Speech Lang Pathol"},{"key":"2024111107500838000_90.10.1147.39","doi-asserted-by":"publisher","DOI":"10.1080\/02687038.2012.725242"},{"key":"2024111107500838000_90.10.1147.40","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1080\/02687038.2015.1100706","article-title":"Comparing multi-modality and constraint-induced treatment for aphasia: a preliminary investigation of generalisation to discourse","volume":"30","author":"Rose","year":"2016","journal-title":"Aphasiology"},{"key":"2024111107500838000_90.10.1147.41","doi-asserted-by":"publisher","DOI":"10.1177\/1545968316662707"},{"key":"2024111107500838000_90.10.1147.42","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1080\/02687038.2015.1071480","article-title":"Constraint-induced aphasia therapy (CIAT): a randomised controlled trial in very early stroke rehabilitation","volume":"30","author":"Ciccone","year":"2016","journal-title":"Aphasiology"},{"key":"2024111107500838000_90.10.1147.43","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304297"},{"key":"2024111107500838000_90.10.1147.44","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/02687038.2015.1070949","article-title":"The role of intensity in constraint-induced language therapy for people with chronic aphasia","volume":"30","author":"Mozeiko","year":"2016","journal-title":"Aphasiology"},{"key":"2024111107500838000_90.10.1147.45","doi-asserted-by":"crossref","first-page":"S285","DOI":"10.1044\/2014_AJSLP-13-0081","article-title":"Dosing of a cued picture-naming treatment for anomia","volume":"23","author":"Harnish","year":"2014","journal-title":"Am J Speech Lang Pathol"},{"key":"2024111107500838000_90.10.1147.46","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1080\/02687038.2015.1100705","article-title":"The impact of dose on naming accuracy with persons with aphasia","volume":"30","author":"Off","year":"2016","journal-title":"Aphasiology"},{"key":"2024111107500838000_90.10.1147.47","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/S0140-6736(17)30067-3","article-title":"Intensive speech and language therapy in patients with chronic aphasia after stroke: a randomised, open-label, blinded-endpoint, controlled trial in a health-care setting","volume":"389","author":"Breitenstein","year":"2017","journal-title":"Lancet"},{"key":"2024111107500838000_90.10.1147.48","doi-asserted-by":"crossref","unstructured":"Stahl B , Mohr B , B\u00fcscher V , et al . Efficacy of intensive aphasia therapy in patients with chronic stroke: a randomised controlled trial. J Neurol Neurosurg Psychiatry 2018;89.doi:10.1136\/jnnp-2017-315962","DOI":"10.1136\/jnnp-2017-315962"},{"key":"2024111107500838000_90.10.1147.49","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.009522"},{"key":"2024111107500838000_90.10.1147.50","doi-asserted-by":"publisher","DOI":"10.1111\/1460-6984.12018"},{"key":"2024111107500838000_90.10.1147.51","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1080\/09602011.2014.899504","article-title":"How justice can affect jury: training Abstract words promotes generalisation to concrete words in patients with aphasia","volume":"24","author":"Sandberg","year":"2014","journal-title":"Neuropsychol Rehabil"},{"key":"2024111107500838000_90.10.1147.52","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/02687038.2014.955389","article-title":"Training pseudoword reading in acquired dyslexia: a phonological complexity approach","volume":"29","author":"Riley","year":"2015","journal-title":"Aphasiology"},{"key":"2024111107500838000_90.10.1147.53","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1044\/2015_JSLHR-L-14-0131","article-title":"The influence of Phonomotor treatment on word retrieval abilities in 26 individuals with chronic aphasia: an open trial","volume":"58","author":"Kendall","year":"2015","journal-title":"J Speech Lang Hear Res"},{"key":"2024111107500838000_90.10.1147.54","doi-asserted-by":"crossref","first-page":"S300","DOI":"10.1044\/2014_AJSLP-13-0083","article-title":"Effects of intensive phonomotor treatment on reading in eight individuals with aphasia and phonological alexia","volume":"23","author":"Brookshire","year":"2014","journal-title":"Am J Speech Lang Pathol"},{"key":"2024111107500838000_90.10.1147.55","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cortex.2016.09.021","article-title":"Using language for social interaction: communication mechanisms promote recovery from chronic non-fluent aphasia","volume":"85","author":"Stahl","year":"2016","journal-title":"Cortex"},{"key":"2024111107500838000_90.10.1147.56","doi-asserted-by":"crossref","first-page":"S312","DOI":"10.1044\/2014_AJSLP-13-0098","article-title":"Effect of Verb network strengthening treatment (VNeST) in persons with aphasia: extension and replication of previous findings","volume":"23","author":"Edmonds","year":"2014","journal-title":"Am J Speech Lang Pathol"},{"key":"2024111107500838000_90.10.1147.57","doi-asserted-by":"publisher","DOI":"10.1177\/1545968313517754"},{"key":"2024111107500838000_90.10.1147.58","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1044\/1092-4388(2013\/12-0224)","article-title":"Delayed stimulus-specific improvements in discourse following anomia treatment using an intentional gesture","volume":"57","author":"Altmann","year":"2014","journal-title":"J Speech Lang Hear Res"},{"key":"2024111107500838000_90.10.1147.59","doi-asserted-by":"crossref","unstructured":"Chen W , Ye Q , Ji X , et al . Mirror neuron system based therapy for aphasia rehabilitation. Frontiers in Psychology 2015;6.doi:10.3389\/fpsyg.2015.01665","DOI":"10.3389\/fpsyg.2015.01665"},{"key":"2024111107500838000_90.10.1147.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.03.083"}],"container-title":["Journal of Neurology, Neurosurgery &amp; Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp-2018-319649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T10:51:38Z","timestamp":1731322298000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnnp.bmj.com\/lookup\/doi\/10.1136\/jnnp-2018-319649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,4]]},"references-count":60,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,9,12]]},"published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1136\/jnnp-2018-319649"],"URL":"https:\/\/doi.org\/10.1136\/jnnp-2018-319649","relation":{},"ISSN":["0022-3050","1468-330X"],"issn-type":[{"value":"0022-3050","type":"print"},{"value":"1468-330X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,4]]}}}