{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:04:22Z","timestamp":1790751862758,"version":"4.1.0"},"reference-count":34,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Neurol Neurosurg Psychiatry"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Sensory neuropathies (SNs) are often classified as idiopathic even if immunological mechanisms can be suspected. Antibodies against the intracellular domain of the fibroblast growth factor receptor 3 (FGFR3) possibly identify a subgroup of SN affecting mostly the dorsal root ganglion (DRG). The aim of this study was to identify the frequency of anti-FGFR3 antibodies and the associated clinical pattern in a large cohort of patients with SN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, multicentric, European and Brazilian study included adults with pure SN. Serum anti-FGRF3 antibodies were analysed by ELISA. Detailed clinical and paraclinical data were collected for each anti-FGFR3-positive patient and as control for anti-FGFR3-negative patients from the same centres (\u2018center-matched\u2019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty-five patients out of 426 (15%) had anti-FGFR3 antibodies, which were the only identified autoimmune markers in 43 patients (66%). The neuropathy was non-length dependent in 89% and classified as sensory neuronopathy in 64%, non-length-dependent small fibre neuropathy in 17% and other neuropathy in 19%. Specific clinical features occurred after 5\u20136 years of evolution including frequent paresthesia, predominant clinical and electrophysiological involvement of the lower limbs, and a less frequent mixed large and small fibre involvement. Brazilians had a higher frequency of anti-FGFR3 antibodies than Europeans (36% vs 13%, p&lt;0.001), and a more frequent asymmetrical distribution of symptoms (OR 169, 95%\u2009CI 3.4 to 8424).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anti-FGFR3 antibodies occur in a subgroup of SN probably predominantly affecting the DRG. Differences between Europeans and Brazilians could suggest involvement of genetic or environmental factors.<\/jats:p><\/jats:sec>","DOI":"10.1136\/jnnp-2019-321849","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T22:25:19Z","timestamp":1572992719000},"page":"49-57","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":66,"title":["Clinical characterisation of sensory neuropathy with anti-FGFR3 autoantibodies"],"prefix":"10.1136","volume":"91","clinical-trial-number":[{"clinical-trial-number":"nct02539329","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct02539329","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1826-3031","authenticated-orcid":false,"given":"Yannick","family":"Tholance","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9294-2323","authenticated-orcid":false,"given":"Christian Peter","family":"Moritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Rosier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Ferraud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Lassabli\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Reynaud-Federspiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcondes C","family":"Fran\u00e7a Jr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto R M","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5282-6707","authenticated-orcid":false,"given":"Jean-Philippe","family":"Camdessanch\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Antoine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,11,5]]},"reference":[{"key":"2020042902343839000_91.1.49.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70096-X"},{"key":"2020042902343839000_91.1.49.2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7423-7"},{"key":"2020042902343839000_91.1.49.3","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000475"},{"key":"2020042902343839000_91.1.49.4","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-309730"},{"key":"2020042902343839000_91.1.49.5","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp136"},{"key":"2020042902343839000_91.1.49.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02930.x"},{"key":"2020042902343839000_91.1.49.7","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn093"},{"key":"2020042902343839000_91.1.49.8","first-page":"468","article-title":"Proper Performance and Interpretation of Electrodiagnostic Studies. 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